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Cited by 1,466Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research StudiesT-cell and B-cell Immunology

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

Hickey, William F., Kimura, Hiromitsu·1988·Science
DOI 10.1126/science.3276004
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Abstract

A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability-restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to present antigen to lymphocytes in an appropriately restricted manner. These findings are important for bone marrow transplantation and for neuroimmunological diseases such as multiple sclerosis.

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Crossref · 10.1126/science.3276004

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Research works printed but not linked: 6

  1. BARKER, C.F., ADVANCES IN IMMUNOLOGY 25: 1 (1971).
  2. COHEN, I.R., PROGRESS IN IMMUNOLOGY 5: 1129 (1984).
  3. DOLMAN, C.L., TXB NEUROPATHOLOGY: 117 (1985).
  4. GRIFFIN, D.E., NEUROIMMUNOLOGY: 193 (1984).
  5. HAGER, H, ACTA NEUROPATHOLOGICA 6: 279 (1975).
  6. Lampson, L. A., Proceedings of the National Academy of Sciences of the United States of America 81: 6476 (1984).

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Metadata

Authors
Hickey, W. F., & Kimura, H.
Affiliations
University of Pennsylvania (US)
ORCID
Hickey, William F.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1988-01-15
Volume
239
Issue
4837
Pages
290-292
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.3276004
OpenAlex
W2076407459
Cited by
1,466
References
32
Citations by year
2026: 6 · 2025: 16 · 2024: 21 · 2023: 13 · 2022: 26 · 2021: 15 · 2020: 19 · 2019: 30 · 2018: 26 · 2017: 33 · 2016: 30 · 2015: 34 · 2014: 32 · 2013: 34 · 2012: 48
FWCI
37.37
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (KO7-NS0087)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
antigen presentation, bone marrow chimeras, bone marrow-derived cells, encephalitogenic T cells, multiple sclerosis, neuroimmunology, bone marrow transplantation
MeSH terms
Animals, Antigen-Presenting Cells, Astrocytes, Bone Marrow, Central Nervous System, Chimera, Encephalomyelitis, Autoimmune, Experimental, Endothelium, Graft vs Host Disease, Histocompatibility Antigens, Immunohistochemistry, Multiple Sclerosis, Neuroglia, Rats, Inbred Lew, T-Lymphocytes, Bone Marrow Transplantation, Rats

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