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NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

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Aging: Central role for autophagy and the lysosomal degradative system

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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

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miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues

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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

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Mammalian circadian clock and metabolism – the epigenetic link

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Osteoblasts in osteoporosis: Past, emerging, and future anabolic targets

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Obesity and aging: Molecular mechanisms and therapeutic approaches

Santos, A. L., & Sinha, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101268 · Cited by 240 · see citing works

The SirT3 Divining Rod Points to Oxidative Stress

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Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

Higashida, K., Kim, S. H., Jung, S. R., Asaka, M., Holloszy, J. O., & Han, D.-H. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001603 · Cited by 228 · see citing works

Small-Molecule Allosteric Activators of Sirtuins

Sinclair, D. A., & Guarente, L. (2011) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134657 · Cited by 223 · see citing works

SIRT1: Regulation of longevity via autophagy

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Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation

Xu, F. L., Gao, Z., Zhang, J., Rivera, C. A., Yin, J., Weng, J., & Ye, J. (2010) · Endocrinology · doi:10.1210/en.2009-1013 · Cited by 221 · see citing works

Health Benefits of Fasting and Caloric Restriction

Golbidi, S., Daiber, A., Korać, B., Li, H., Essop, M. F., & Laher, I. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0951-7 · Cited by 218 · see citing works

FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

Xiong, S., Salazar, G., Patrushev, N. A., & Alexander, R. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.163667 · Cited by 216 · see citing works

NAD and the aging process: role in life, death and everything in between

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Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

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The coordination of nuclear and mitochondrial communication during aging and calorie restriction

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Sirtuins, Aging, and MetabolismPreprint

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The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

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Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

Schenk, S., McCurdy, C. E., Philp, A., Chen, M. Z., Holliday, M. J., Bandyopadhyay, G. K., Osborn, O., Baar, K., & Olefsky, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58554 · Cited by 197 · see citing works

NAD+/NADH and skeletal muscle mitochondrial adaptations to exercise

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NAD ⁺ metabolism: A therapeutic target for age-related metabolic disease

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Mammalian Sirtuins and Energy Metabolism

Li, X., & Kazgan, N. (2011) · International Journal of Biological Sciences · doi:10.7150/ijbs.7.575 · Cited by 192 · see citing works

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling

Khan, S. A., Sathyanarayan, A., Mashek, M. T., Ong, K. T., Wollaston‐Hayden, E. E., & Mashek, D. G. (2015) · Diabetes · doi:10.2337/db14-0325 · Cited by 189 · see citing works

Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise

Philp, A., Chen, A., Lan, D., Meyer, G. A., Murphy, A. N., Knapp, A. E., Olfert, I. M., McCurdy, C. E., Marcotte, G. R., Hogan, M. C., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.261685 · Cited by 184 · see citing works

Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice

Escande, C., Chini, C. C. S., Nin, V., Dykhouse, K. M., Novak, C. M., Levine, J. A., van Deursen, J., Gores, G. J., Chen, J., Lou, Z., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39319 · Cited by 186 · see citing works

Activation of Stress Response Gene SIRT1 by BCR-ABL Promotes Leukemogenesis

Yuan, H., Wang, Z., Li, L., Zhang, H., Modi, H., Horne, D., Bhatia, R., & Chen, W. (2012) · Blood · doi:10.1182/blood-2011-06-361691 · Cited by 182 · see citing works

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

Erion, D. M., Yonemitsu, S., Nie, Y., Nagai, Y., Gillum, M. P., Hsiao, J. J., Iwasaki, T., Stark, R., Weismann, D., Yu, X. X., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812931106 · Cited by 181 · see citing works

Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restrictionPreprint

Cohen, D. E., Supinski, A., Bonkowski, M. S., Dönmez, G., & Guarente, L. (2009) · Genes & Development · doi:10.1101/gad.1839209 · Cited by 178 · see citing works

SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

Wang, Y., Liang, Y. Q., & Vanhoutte, P. M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.047 · Cited by 175 · see citing works

Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover

Palikaras, K., Daskalaki, I., Markaki, M., & Tavernarakis, N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.04.005 · Cited by 175 · see citing works

The Role of Mammalian Sirtuins in the Regulation of Metabolism, Aging, and Longevity

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Converging Pathways in Lifespan Regulation

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Caloric restriction: From soup to nuts

Spindler, S. R. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.10.003 · Cited by 168 · see citing works

Sirtuin 1-mediated Effects of Exercise and Resveratrol on Mitochondrial Biogenesis

Menzies, K. J., Singh, K., Saleem, A., & Hood, D. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.431155 · Cited by 167 · see citing works

Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels

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Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases

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Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes

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Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms

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Resveratrol and life extension

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Calorie restriction and the exercise of chromatinPreprint

Vaquero, A., & Reinberg, D. (2009) · Genes & Development · doi:10.1101/gad.1807009 · Cited by 154 · see citing works

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice-2

Gino Boily, E. L. S. (2011) · Figshare · doi:10.6084/m9.figshare.74044

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice-5

Gino Boily, E. L. S. (2011) · Figshare · doi:10.6084/m9.figshare.74046

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice-0

Gino Boily, E. L. S. (2011) · Figshare · doi:10.6084/m9.figshare.74043

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice-10

Gino Boily, E. L. S. (2011) · Figshare · doi:10.6084/m9.figshare.74052

Increase in Activity During Calorie Restriction Requires Sirt1

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