The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Fish Oils Inhibit Endothelial Cell Production of Platelet-Derived Growth Factor-Like Protein
Abstract
Diets rich in fish and fish oils are associated with a reduced risk of cardiovascular disease and atherosclerosis. The interaction of a commercial fish oil extract (MaxEPA) with vascular endothelial cells (ECs) was studied as a possible mechanism for this protective effect. MaxEPA almost completely inhibited EC production of platelet-derived growth factor-like protein (PDGFc) while other lipids had a lesser effect or no effect. Overall protein synthesis was not reduced, nor was the inhibition due to defective secretion or increased degradation of the growth factor. Antioxidants suppressed the inhibitory activity of MaxEPA indicating that free radical oxidative processes were required for the inhibition. These results suggest that fish oils may suppress intimal smooth muscle cell proliferation by decreasing the production of EC-derived paracrine growth factors. This inhibitory process represents a possible molecular mechanism for the antiatherosclerotic action of marine lipids.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart Disease
Kromhout, D., Bosschieter, E. B., & Coulander, C. D. L. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121901 · Cited by 2,177
Cited by
Omega-3 fatty acids in health and disease and in growth and development.
Simopoulos, A. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.438 · Cited by 2,162
Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis
Ross, R., Masuda, J., Raines, E. W., Gown, A. M., Katsuda, S., Sasahara, M., Malden, L. T., Masuko, H., & Sato, H. (1990) · Science · doi:10.1126/science.2343305 · Cited by 574
Iso, H., Kobayashi, M., Ishihara, J., Sasaki, S., Okada, K., Kita, Y., Kokubo, Y., & Tsugane, S. (2006) · Circulation · doi:10.1161/circulationaha.105.581355 · Cited by 557
DeCaterina, R., Giannessi, D., Mazzone, A., Bernini, W., Lazzerini, G., Maffei, S., Cerri, M., Salvatore, L., & Weksler, B. (1990) · Circulation · doi:10.1161/01.cir.82.2.428 · Cited by 134
N‐3 Fatty Acids from Fish Oil: Effects on Plasma Lipoproteins and Hypertriglyceridemic Patients a
CONNOR, W. E., DeFRANCESCO, C. A., & CONNOR, S. L. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb35689.x · Cited by 119
Metadata
- Authors
- Fox, P. L., & DiCorleto, P. E.
- Venue
- Science
- Published
- 1988-07-22
- Volume
- 241
- Issue
- 4864
- Pages
- 453-456
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984515155
- Cited by
- 265
- References
- 1
- FWCI
- 32.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fish Oils Inhibit Endothelial Cell Production of Platelet-Derived Growth Factor-Like Protein. https://app.cochat.ai/papers/10.1126/science.3393911
- The paper
- Fox, P. L., & DiCorleto, P. E. (1988). Fish Oils Inhibit Endothelial Cell Production of Platelet-Derived Growth Factor-Like Protein. Science. https://doi.org/10.1126/science.3393911
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
