Microbiota Modulation of Myeloid Cells in Cancer Therapy
Open accessAbstract
Myeloid cells represent a major component of the tumor microenvironment, where they play divergent dual roles. They can induce antitumor immune responses, but mostly they promote immune evasion, tumor progression, and metastasis formation. Thus, strategies aiming at reprogramming the tumor microenvironment represent a promising immunotherapy approach. Myeloid cells respond to environmental factors including signals derived from commensal microbes. In this Cancer Immunology at the Crossroads overview, we discuss recent advances on the effects of the commensal microbiota on myeloid-cell functions and how they affect the response to cancer therapy. Cancer Immunol Res; 3(2); 103–9. ©2015 AACR.
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The gut microbiome is a major tumor-extrinsic regulator of anti-PD-1 responses.
“the gut microbiome is a major tumor-extrinsic regulator of responses to anti–PD-1 (6–9).”
From Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients (2021) · cites this paper as [8]
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- Authors
- Goldszmid, R. S., Dzutsev, A., Viaud, S., Zitvogel, L., Restifo, N. P., & Trinchieri, G.
- Affiliations
- National Institutes of Health (US)
- Université Paris-Sud (FR)
- Corresponding author
- Trinchieri, Giorgio
- Venue
- Cancer Immunology Research
- Published
- 2015-02-01
- Volume
- 3
- Issue
- 2
- Pages
- 103-109
- ISSN
- 2326-6066 (ISSN-L)
- 2326-6074
- PMC
- PMC4324508
- OpenAlex
- W1971200113
- Cited by
- 46
- References
- 72
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 4 · 2018: 1 · 2017: 9 · 2016: 7 · 2015: 2
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Immunology Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (ZIABC011153)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- myeloid cells, tumor microenvironment, commensal microbiota, gut microbiota, cancer immunotherapy, immune evasion, tumor progression, metastasis, myeloid reprogramming, antitumor immunity
- MeSH terms
- Animals, Cell Differentiation, Humans, Inflammation, Neoplasms, Symbiosis, Myeloid Cells, Tumor Microenvironment, Microbiota
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