The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A New Approach to the Oral Administration of Insulin and Other Peptide Drugs
Abstract
The oral administration of peptide drugs is well known to be precluded by their digestion in the stomach and small intestine. As a new approach to oral delivery, peptide drugs were coated with polymers cross-linked with azoaromatic groups to form an impervious film to protect orally administered drugs from digestion in the stomach and small intestine. When the azopolymer-coated drug reached the large intestine, the indigenous microflora reduced the azo bonds, broke the cross-links, and degraded the polymer film, thereby releasing the drug into the lumen of the colon for local action or for absorption. The ability of the azopolymer coating to protect and deliver orally administered peptide drugs was demonstrated in rats with the peptide hormones vasopressin and insulin.
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Citations
Cites
Bliss, M. (1982) · doi:10.1007/978-1-349-09612-1 · Cited by 524
Cited by
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Sinha, V. R., & Kumria, R. (2001) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00720-7 · Cited by 872
Approaches for enhancing oral bioavailability of peptides and proteins
Renukuntla, J., Vadlapudi, A. D., Patel, A., Boddu, S. H. S., & Mitra, A. K. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.030 · Cited by 681
A holistic approach to targeting disease with polymeric nanoparticles
Cheng, C. J., Tietjen, G. T., Saucier-Sawyer, J. K., & Saltzman, W. M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4503 · Cited by 480
Cevc, G., Gebauer, D., Stieber, J., Schätzlein, A., & Blume, G. (1998) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(97)00177-6 · Cited by 478
Colon Targeted Drug Delivery Systems: A Review on Primary and Novel Approaches
Philip, A., & Philip, B. (2010) · Oman Medical Journal · doi:10.5001/omj.2010.24 · Cited by 330
Metadata
- Authors
- Saffran, M., Kumar, G. S., Savariar, C., Burnham, J. C., Williams, F., & Neckers, D. C.
- Venue
- Science
- Published
- 1986-09-05
- Volume
- 233
- Issue
- 4768
- Pages
- 1081-1084
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027742586
- Cited by
- 469
- References
- 1
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saffran, M., Kumar, G. S., Savariar, C., Burnham, J. C., Williams, F., & Neckers, D. C. (1986). A New Approach to the Oral Administration of Insulin and Other Peptide Drugs. Science. https://doi.org/10.1126/science.3526553
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
