The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo
Abstract
The mouse heavy chain immunoglobulin gene contains a tissue-specific enhancer. The enhancer and flanking sequences were studied in vivo by carrying out dimethyl sulfate protection experiments on living cells, in combination with genomic sequencing. Relative to reactions on naked DNA, there are changes (protections and enhancements) in the reactivity of guanine residues to dimethyl sulfate within the enhancer sequence in myeloma, B, and early B cells, whereas virtually no alterations appear in cells of non-B lineage. Most of the affected residues are in four clusters, in sequences homologous to the octamer 5′CAGGTGGC 3′ (C, cytosine; A, adenine; G. guanine; T, thymine). The alterations in the pattern of G reactivity are consistent with the tissue-specific binding of molecules to the mouse immunoglobulin heavy chain enhancer.
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Citations
Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Self-citationExpression of a β-globin gene is enhanced by remote SV40 DNA sequences
Banerji, J., Rusconi, S., & Schaffner, W. (1981) · Cell · doi:10.1016/0092-8674(81)90413-x · Cited by 1,724
Cited by
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,752
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765
BAIN, G. (1994) · Cell · doi:10.1016/0092-8674(94)90077-9 · Cited by 635
Johnson, P. F., Landschulz, W. H., Graves, B. J., & McKnight, S. L. (1987) · Genes & Development · doi:10.1101/gad.1.2.133 · Cited by 595
Oct-4: a germline-specific transcription factor mapping to the mouse t-complex.
Schöler, H. R., Dressler, G. R., Balling, R., Rohdewohld, H., & Gruss, P. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07388.x · Cited by 586
Metadata
- Authors
- Ephrussi, A., Church, G. M., Tonegawa, S., & Gilbert, W.
- Venue
- Science
- Published
- 1985-01-11
- Volume
- 227
- Issue
- 4683
- Pages
- 134-140
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013545053
- Cited by
- 796
- References
- 2
- FWCI
- 33.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ephrussi, A., Church, G. M., Tonegawa, S., & Gilbert, W. (1985). B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo. Science. https://doi.org/10.1126/science.3917574
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
