The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils
Abstract
In a study of the relation between chronic inflammation and carcinogenesis, C3H mouse fibroblasts of the 10T 1/2 clone 8 line (10T 1/2 cells) were exposed to human neutrophils stimulated to synthesize reactive oxygen intermediates or to a cell-free enzymatic system generating superoxide (xanthine oxidase plus hypoxanthine). After exposure, the 10T 1/2 cells were either placed in tissue culture or immediately injected into athymic nude mice. Both malignant and benign tumors developed in the mice injected with treated cells, but not in those injected with control cells; in one instance cells grown from one of the benign tumors subsequently developed a malignant phenotype. Malignant transformation was also observed in treated cells in the experiments in vitro.
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Citations
Cites
Reznikoff, C. A., Bertram, J. S., Brankow, D. W., & Heidelberger, C. (1973) · PubMed · Cited by 827
Chlorination of Taurine by Human Neutrophils
Weiss, S. J., Klein, R., Slivka, A., & Wei, M. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110652 · Cited by 805
Levin, D. E., Hollstein, M., Christman, M. F., Schwiers, E. A., & Ames, B. N. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.23.7445 · Cited by 751
Radioprotectors and anticarcinogens
Anticarcinogens, Nygaard, O. F., Simic, M. G., & Hauber, J. N. (1983) · Academic Press eBooks · Cited by 610
Long-Lived Oxidants Generated by Human Neutrophils: Characterization and Bioactivity
Weiss, S. J., Lampert, M. B., & Test, S. T. (1983) · Science · doi:10.1126/science.6635660 · Cited by 388
Fulton, A. M., Loveless, S. E., & Heppner, G. H. (1984) · PubMed · Cited by 292
Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells.
Mondal, S., Brankow, D. W., & Heidelberger, C. (1976) · PubMed · Cited by 291
Role of superoxide in deoxyribonucleic acid strand scission
Lesko, S. A., Lorentzen, R. J., & Ts'o, P. O. P. (1980) · Biochemistry · doi:10.1021/bi00554a029 · Cited by 278
Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells
Weitberg, A. B., Weitzman, S. A., Destrempes, M., Latt, S. A., & Stossel, T. P. (1983) · New England Journal of Medicine · doi:10.1056/nejm198301063080107 · Cited by 262
Self-citationMutation Caused by Human Phagocytes
Weitzman, S. A., & Stossel, T. P. (1981) · Science · doi:10.1126/science.6259738 · Cited by 260
Self-citation
Cited by
Beyond oxidative stress: an immunologist's guide to reactive oxygen species
Nathan, C., & Cunningham-Bussel, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3423 · Cited by 1,619
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
Free Radicals as Mediators of Tissue Injury and Disease
Kehrer, J. P. (1993) · Critical Reviews in Toxicology · doi:10.3109/10408449309104073 · Cited by 1,455
Oxidative stress and cancer: Have we moved forward?
Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302
Phagocytes and oxidative stress
Babior, B. M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00481-2 · Cited by 1,061
Metadata
- Authors
- Weitzman, S. A., Weitberg, A. B., Clark, E. P., & Stossel, T. P.
- Venue
- Science
- Published
- 1985-03-08
- Volume
- 227
- Issue
- 4691
- Pages
- 1231-1233
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081608638
- Cited by
- 441
- References
- 17
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Weitzman, S. A., Weitberg, A. B., Clark, E. P., & Stossel, T. P. (1985). Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils. Science. https://doi.org/10.1126/science.3975611
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
