The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells
Abstract
CHRONIC inflammation can be associated with cancer.1 Phagocytes in inflammatory lesions enzymatically reduce oxygen to reactive metabolites, which include Superoxide anions, hydrogen peroxide, and hydroxyl radicals. These reactive species kill microorganisms, damage DNA, and lyse mammalian cells.2 3 4 5 6 Sublethal damage to genetic material in inflamed foci caused by phagocyte-derived oxygen metabolites may be one mechanism by which cancer arises in the presence of inflammation. The observation that human phagocytes are important in this mutagenic process7 8 9 is consistent with this idea, since there is a strong correlation between mutagenesis and carcinogenesis.10 In this paper we report that human phagocytes that are activated . . .
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Citations
Cites
Oxygen metabolism and the toxic properties of phagocytes
KLEBANOFF, S. J. (1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-93-3-480 · Cited by 868
Cited by
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity
Hudson, J. D., Shoaibi, M. A., Maestro, R., Carnero, A., Hannon, G. J., & Beach, D. H. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.10.1375 · Cited by 649
Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils
Weitzman, S. A., Weitberg, A. B., Clark, E. P., & Stossel, T. P. (1985) · Science · doi:10.1126/science.3975611 · Cited by 441
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Metadata
- Authors
- Weitberg, A. B., Weitzman, S. A., Destrempes, M., Latt, S. A., & Stossel, T. P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1983-01-06
- Volume
- 308
- Issue
- 1
- Pages
- 26-30
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2069860437
- Cited by
- 262
- References
- 1
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells. https://app.cochat.ai/papers/10.1056/nejm198301063080107
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- Weitberg, A. B., Weitzman, S. A., Destrempes, M., Latt, S. A., & Stossel, T. P. (1983). Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells. New England Journal of Medicine. https://doi.org/10.1056/nejm198301063080107
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
