The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glucocorticoids Potentiate Ischemic Injury to Neurons: Therapeutic Implications
Abstract
Sustained exposure to glucocorticoids, the adrenocortical stress hormones, is toxic to neurons, and such toxicity appears to play a role in neuron loss during aging. Previous work has shown that glucocorticoids compromise the capacity of neurons to survive a variety of metabolic insults. This report extends those observations by showing that ischemic injury to neurons in rat brain is also potentiated by exposure to high physiological titers of glucocorticoids and is attenuated by adrenalectomy. The synergy between ischemic and glucocorticoid brain injury was seen even when glucocorticoid levels were manipulated after the ischemic insult. Pharmacological interventions that diminish the adrenocortical stress response may improve neurological outcome from stroke or cardiac arrest.
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Citations
Cites
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Cited by
Hao (2015) · doi:10.1002/14651858 · Cited by 11,321
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.973 · Cited by 1,610
Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., Capelli, S., McCarthy, G., Innis, R. B., & Charney, D. S. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00162-x · Cited by 1,283
Mood disorders and allostatic load
McEwen, B. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00177-x · Cited by 1,135
Hippocampal damage associated with prolonged glucocorticoid exposure in primates
Sapolsky, R., Uno, H., Rebert, C., & Finch, C. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-09-02897.1990 · Cited by 1,103
Self-citation
Metadata
- Authors
- Sapolsky, R. M., & Pulsinelli, W. A.
- Venue
- Science
- Published
- 1985-09-27
- Volume
- 229
- Issue
- 4720
- Pages
- 1397-1400
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005374086
- Cited by
- 676
- References
- 1
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
