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Cited by 376

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Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful Stimuli

Frederickson, Robert C. A., Burgis, Vigo, Edwards, J. David·1977·Science

Abstract

A diurnal rhythm was observed in the responsiveness of mice to nociceptive stimuli and in the hyperalgesic activity of naloxone. These rhythms may follow a diurnal rhythmicity in the activity of endogenous opioid peptides and may partly account for previous controversy over the direct action of naloxone in opiate-naive animals.

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Metadata

Authors
Frederickson, R. C. A., Burgis, V., & Edwards, J. D.
Venue
Science
Published
1977-11-18
Volume
198
Issue
4318
Pages
756-758
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2029856705
Cited by
376
References
0
FWCI
41.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful Stimuli. https://app.cochat.ai/papers/10.1126/science.561998
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Frederickson, R. C. A., Burgis, V., & Edwards, J. D. (1977). Hyperalgesia Induced by Naloxone Follows Diurnal Rhythm in Responsivity to Painful Stimuli. Science. https://doi.org/10.1126/science.561998

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.