The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone
Abstract
Heparin or a heparin fragment administered with cortisone inhibited angiogenesis, caused regression of large tumor masses, and prevented metastases. Oral administration of heparin resulted in the release of non-anticoagulant heparin fragments in the serum which, in the presence of cortisone, had similar anti-angiogenic and antitumor effects. Of all the heparin fragments tested, the most potent inhibition of angiogenesis in the presence of cortisone was provided by a hexasaccharide with a molecular weight of about 1600.
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Citations
Cites
Polymers for the sustained release of proteins and other macromolecules
LANGER, R., & FOLKMAN, J. (1976) · Nature · doi:10.1038/263797a0 · Cited by 1,182
Self-citation
Cited by
Folkman, J., & Klagsbrun, M. (1987) · Science · doi:10.1126/science.2432664 · Cited by 3,491
Self-citationHeparin and heparan sulfate: Structure and function
Rabenstein, D. L. (2002) · Natural Product Reports · doi:10.1039/b100916h · Cited by 870
Mechanisms of normal and tumor-derived angiogenesis
Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809
Ornitz, D. M., Yayon, A., Flanagan, J. G., Svahn, C. M., Levi, E., & Leder, P. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.240 · Cited by 632
The Hypercoagulable State of Malignancy: Pathogenesis and Current Debate
Caine, G. J., Stonelake, P. S., Lip, G. Y. H., & Kehoe, S. T. (2002) · Neoplasia · doi:10.1038/sj.neo.7900263 · Cited by 576
Metadata
- Authors
- Folkman, J., Langer, R., Linhardt, R. J., Haudenschild, C., & Taylor, S.
- Venue
- Science
- Published
- 1983-08-19
- Volume
- 221
- Issue
- 4612
- Pages
- 719-725
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058727554
- Cited by
- 619
- References
- 1
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone. https://app.cochat.ai/papers/10.1126/science.6192498
- The paper
- Folkman, J., Langer, R., Linhardt, R. J., Haudenschild, C., & Taylor, S. (1983). Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone. Science. https://doi.org/10.1126/science.6192498
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
