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Photosynthesis of Previtamin D 3 in Human Skin and the Physiologic Consequences
Abstract
Photosynthesis of previtamin D 3 can occur throughout the epidermis and in the dermis when hypopigmented Caucasian skin is exposed to solar ultraviolet radiation. Once previtamin D 3 is formed in the skin, it undergoes a temperature-dependent thermal isomerization that takes at least 3 days to complete. The vitamin D-binding protein preferentially translocates the thermal product, vitamin D 3 , into the circulation. These processes suggest a unique mechanism for the synthesis, storage, and slow, steady release of vitamin D 3 from the skin into the circulation.
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Citations
Cited by
Decreased bioavailability of vitamin D in obesity
Wortsman, J., Matsuoka, L. Y., Chen, T. C., Lu, Z., & Holick, M. F. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.3.690 · Cited by 3,204
Self-citationVitamin D metabolism, mechanism of action, and clinical applications
Bikle, D. D. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.12.016 · Cited by 1,933
The Protective Role of Melanin Against UV Damage in Human Skin †
Brenner, M., & Hearing, V. J. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00226.x · Cited by 1,741
Vitamin D for health: a global perspective
Hossein-nezhad, A., & Holick, M. F. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.05.011 · Cited by 1,298
Self-citationOxidation events and skin aging
Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980
Metadata
- Authors
- Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., Potts, J. T., Anderson, R. R., Blank, I. H., Parrish, J. A., & Elias, P.
- Venue
- Science
- Published
- 1980-10-10
- Volume
- 210
- Issue
- 4466
- Pages
- 203-205
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2080844332
- Cited by
- 776
- References
- 0
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Holick, M. F., MacLaughlin, J. A., Clark, M. B., Holick, S. A., Potts, J. T., Anderson, R. R., Blank, I. H., Parrish, J. A., & Elias, P. (1980). Photosynthesis of Previtamin D 3 in Human Skin and the Physiologic Consequences. Science. https://doi.org/10.1126/science.6251551
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