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Transposition of Cloned P Elements into Drosophila Germ Line Chromosomes
Abstract
Recombinant DNA carrying the 3-kilobase P transposable element was injected into Drosophila embryos of a strain that lacked such elements. Under optimum conditions, half of the surviving embryos showed evidence of P element-induced mutations in a fraction of their progeny. Direct analysis of the DNA of strains derived from such flies showed them to contain from one to five intact 3-kilobase P elements located at a wide variety of chromosomal sites. DNA sequences located outside the P element on the injected DNA were not transferred. Thus P elements can efficiently and selectively transpose from extrachromosomal DNA to the DNA of germ line chromosomes in Drosophila embryos. These observations provide the basis for efficient DNA-mediated gene transfer in Drosophila .
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Cited by
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Golic, K. G., & Lindquist, S. (1989) · Cell · doi:10.1016/0092-8674(89)90033-0 · Cited by 942
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959
Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801
Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila
Gompel, N., Prud'homme, B., Wittkopp, P. J., Kassner, V. A., & Carroll, S. B. (2005) · Nature · doi:10.1038/nature03235 · Cited by 646
Yin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T. (1995) · Cell · doi:10.1016/0092-8674(95)90375-5 · Cited by 642
Metadata
- Authors
- Spradling, A. C., & Rubin, G. M.
- Venue
- Science
- Published
- 1982-10-22
- Volume
- 218
- Issue
- 4570
- Pages
- 341-347
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2103080800
- Cited by
- 1,558
- References
- 0
- FWCI
- 83.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Spradling, A. C., & Rubin, G. M. (1982). Transposition of Cloned P Elements into Drosophila Germ Line Chromosomes. Science. https://doi.org/10.1126/science.6289435
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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