Cited by 642Neurobiology and Insect Physiology ResearchMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

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Yin, J.C.P, Del Vecchio, M, Zhou, H, Tully, T·1995·Cell

Abstract

Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed.

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Crossref · 10.1016/0092-8674(95)90375-5

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69 of 69 references verified0 citation errors · 0 not checkable

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  • Two isoforms of Drosophila melanogaster CREB - dCREB2-a and dCREB2-r - can activate and repress transcription, respectively.

    “Two isoforms of D. melanogaster CREB — dCREB2-a and dCREB2-r — can activate and repress transcription, respectively.”

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Authors
Yin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T.
Affiliations
Cold Spring Harbor Laboratory (US)
Venue
Cell
Publisher
Elsevier BV
Published
1995-04
Volume
81
Issue
1
Pages
107-115
ISSN
0092-8674 (ISSN-L)
OpenAlex
W1973707586
Cited by
642
References
69
Citations by year
2026: 6 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 14 · 2021: 12 · 2020: 7 · 2019: 12 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 18 · 2014: 17 · 2013: 19 · 2012: 21
FWCI
13.72
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
Funders
  • National Institutes of Health (2r01hd032245-04)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-32245)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
CREB, long-term memory, memory formation, protein synthesis-dependent memory, CREB phosphorylation, Drosophila
MeSH terms
Animals, Avoidance Learning, Drosophila, Hot Temperature, Memory, Models, Genetic, Mutation, Phosphorylation, Trans-Activators, Gene Expression, Genes, Insect, Cyclic AMP Response Element-Binding Protein, Animals, Genetically Modified

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