CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila
Open accessAbstract
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed.
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Two isoforms of Drosophila melanogaster CREB - dCREB2-a and dCREB2-r - can activate and repress transcription, respectively.
“Two isoforms of D. melanogaster CREB — dCREB2-a and dCREB2-r — can activate and repress transcription, respectively.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [64]
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- Authors
- Yin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 81
- Issue
- 1
- Pages
- 107-115
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1973707586
- Cited by
- 642
- References
- 69
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 14 · 2021: 12 · 2020: 7 · 2019: 12 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 18 · 2014: 17 · 2013: 19 · 2012: 21
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Funders
- National Institutes of Health (2r01hd032245-04)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-32245)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- CREB, long-term memory, memory formation, protein synthesis-dependent memory, CREB phosphorylation, Drosophila
- MeSH terms
- Animals, Avoidance Learning, Drosophila, Hot Temperature, Memory, Models, Genetic, Mutation, Phosphorylation, Trans-Activators, Gene Expression, Genes, Insect, Cyclic AMP Response Element-Binding Protein, Animals, Genetically Modified
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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