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Retarding Effect of Lowered Heart Rate on Coronary Atherosclerosis
Abstract
The role of heart rate in the development of coronary atherosclerosis was assessed in adult male cynomolgus monkeys ( Macaca fascicularis ). Heart rate was lowered in six animals by surgical ablation of the sinoatrial node. A sham procedure, which included all of the surgical steps except for sinoatrial node ablation, was carried out in eight animals. All of the monkeys were fed an atherogenic high cholesterol diet for 6 months, and heart rates were monitored repeatedly by telemetry during 24-hour test periods. Coronary atherosclerosis in animals with postoperative heart rates less than the preoperative mean for all of the animals that underwent surgery was less than half that of animals with heart rates above the mean or of diet-fed control animals not subjected to surgery. Groups did not differ in blood pressure, serum lipids, or body weight. These results suggest that heart rate in itself may contribute to the mechanisms by which behavioral patterns and physical training influence coronary artery disease.
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Cited by
Graham (2007) · doi:10.1097/01.hjr.0000277983.23934.c9 · Cited by 1,647
Diaz, A., Bourassa, M. G., Guertin, M.-C., & Tardif, J.-C. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi190 · Cited by 790
Physical Fitness as a Predictor of Mortality among Healthy, Middle-Aged Norwegian Men
Sandvik, L., Erikssen, J., Thaulow, E., Erikssen, G., Mundal, R., & Rodahl, K. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302253280803 · Cited by 788
Depression, the autonomic nervous system, and coronary heart disease
Carney, R. M., Freedland, K. E., & Veith, R. C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000162254.61556.d5 · Cited by 582
Benowitz, N. L., & Gourlay, S. G. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00079-x · Cited by 529
Metadata
- Authors
- Beere, P. A., Glagov, S., & Zarins, C. K.
- Venue
- Science
- Published
- 1984-10-12
- Volume
- 226
- Issue
- 4671
- Pages
- 180-182
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057393088
- Cited by
- 356
- References
- 0
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Beere, P. A., Glagov, S., & Zarins, C. K. (1984). Retarding Effect of Lowered Heart Rate on Coronary Atherosclerosis. Science. https://doi.org/10.1126/science.6484569
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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