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Cited by 356

The DOI matches its Crossref record.

Retarding Effect of Lowered Heart Rate on Coronary Atherosclerosis

Beere, Polly A., Glagov, Seymour, Zarins, Christopher K.·1984·Science
DOI 10.1126/science.6484569
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Abstract

The role of heart rate in the development of coronary atherosclerosis was assessed in adult male cynomolgus monkeys ( Macaca fascicularis ). Heart rate was lowered in six animals by surgical ablation of the sinoatrial node. A sham procedure, which included all of the surgical steps except for sinoatrial node ablation, was carried out in eight animals. All of the monkeys were fed an atherogenic high cholesterol diet for 6 months, and heart rates were monitored repeatedly by telemetry during 24-hour test periods. Coronary atherosclerosis in animals with postoperative heart rates less than the preoperative mean for all of the animals that underwent surgery was less than half that of animals with heart rates above the mean or of diet-fed control animals not subjected to surgery. Groups did not differ in blood pressure, serum lipids, or body weight. These results suggest that heart rate in itself may contribute to the mechanisms by which behavioral patterns and physical training influence coronary artery disease.

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Metadata

Authors
Beere, P. A., Glagov, S., & Zarins, C. K.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1984-10-12
Volume
226
Issue
4671
Pages
180-182
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.6484569
OpenAlex
W2057393088
Cited by
356
References
0
FWCI
4.53
Type
journal article
Language
en
Open access
closed

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