The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Intrahippocampal Septal Grafts Ameliorate Learning Impairments in Aged Rats
Abstract
Grafts of fetal septal tissue rich in cholinergic neurons were implanted as a dissociated cell suspension into the depth of the hippocampal formation in aged rats with severe impairments in spatial learning abilities. After 2½ to 3 months, the rats with grafts, but not the controls, had improved their performance in a spatial learning test. Their improvement was due, at least in part, to an increased ability to use spatial cues in the task. In all animals the grafts had produced an extensive acetylcholinesterase-positive terminal network in the surrounding host hippocampal formation. Thus, the action of cholinergic neurons in the graft onto elements in the host hippocampal circuitry may be a necessary, but perhaps not sufficient, prerequisite for the observed functional recovery.
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Cites
Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
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Bartus, R. T., Dean, R. L., Sherman, K. A., Friedman, E., & Beer, B. (1981) · Neurobiology of Aging · doi:10.1016/0197-4580(81)90007-5 · Cited by 140
Cited by
Katzman, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198604103141506 · Cited by 801
Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease
Coleman, P. D., & Flood, D. G. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90127-8 · Cited by 772
Impact of aging on hippocampal function: plasticity, network dynamics, and cognition
Rosenzweig, E. S., & Barnes, C. A. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00126-0 · Cited by 733
Herkenham, M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90268-5 · Cited by 520
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Metadata
- Authors
- Gage, F. H., Björklund, A., Stenevi, U., Dunnett, S. B., & Kelly, P. A. T.
- Venue
- Science
- Published
- 1984-08-03
- Volume
- 225
- Issue
- 4661
- Pages
- 533-536
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963480747
- Cited by
- 367
- References
- 4
- FWCI
- 17.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gage, F. H., Björklund, A., Stenevi, U., Dunnett, S. B., & Kelly, P. A. T. (1984). Intrahippocampal Septal Grafts Ameliorate Learning Impairments in Aged Rats. Science. https://doi.org/10.1126/science.6539949
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