Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages
Abstract
When cultured in a hypoxic environment similar to that found in the center of a wound, macrophages secreted active angiogenesis factor into the medium. Under conditions similar to those of well-oxygenated tissue, macrophages did not secrete active angiogenesis factor. Macrophages that secreted the factor at hypoxic conditions stopped secreting it when returned to room air. Thus the control of angiogenesis in wound healing may be the result of macrophages responding to tissue oxygen tension without the necessity of interacting with other cell types or biochemical signals.
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The proliferative phase of wound healing involves cell proliferation, angiogenesis, new extracellular matrix deposition, and granulation tissue formation, processes largely mediated by the local microenvironment (pH, oxygen tension) and cytokines secreted by macrophages, T lymphocytes, and other wound-site cells.
“The proliferative phase of wound healing involves cellular proliferation, angiogenesis, new ECM deposition, and the formation of granulation tissue – processes that are largely mediated via the effects of the local microenvironment including pH and oxygen tension, and cytokines secreted by macrophages, T lymphocytes, and other cells within the wound site [91,98,99].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [98]
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“macrophages, T lymphocytes, and other cells within the wound site [91,98,99].”
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Self-citation
- Authors
- Knighton, D. R., Hunt, T. K., Scheuenstuhl, H., Halliday, B. J., Werb, Z., & Banda, M. J.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Werb, Zena
- Venue
- Science
- Published
- 1983-09-23
- Volume
- 221
- Issue
- 4617
- Pages
- 1283-1285
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053060309
- Cited by
- 685
- References
- 1
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 9 · 2020: 13 · 2019: 9 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 8 · 2013: 23 · 2012: 12
- FWCI
- 31.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- oxygen partial pressure, hypoxia, macrophages, angiogenic factors, angiogenesis, wound healing
- MeSH terms
- Animals, Hypoxia, Cells, Cultured, Cornea, Growth Substances, Macrophages, Models, Biological, Oxygen, Rabbits, Wound Healing, Angiogenesis Inducing Agents
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