Cited by 405Neurogenesis and neuroplasticity mechanismsCardiovascular and exercise physiologyBarrier Structure and Function Studies

Exercise and the Brain: Angiogenesis in the Adult Rat Cerebellum after Vigorous Physical Activity and Motor Skill Learning

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Isaacs, Krystyna R., Anderson, Brenda J., Alcantara, Adriana A., Black, James E., Greenough, William T.·1992·Journal of Cerebral Blood Flow & Metabolism

Abstract

This study compared the morphology of cerebellar cortex in adult female rats exposed for 1 month to repetitive exercise, motor learning, or an inactive condition. In the exercise conditions, rats that were run on a treadmill or housed with access to a running wheel had a shorter diffusion distance from blood vessels in the molecular layer of the paramedian lobule when compared to rats housed individually or rats that participated in a motor skill learning task. Rats taught complex motor skills substantially increased the volume of the molecular layer per Purkinje neuron and increased blood vessel number sufficiently to maintain the diffusion distance. These results dissociate angiogenesis associated with increased neuropil volume (as seen in the motor learning group) from angiogenesis associated with increased metabolic demands (as seen in the exercise groups). While the volume fraction of mitochondria did not differ among groups, the mitochondrial volume fraction per Purkinje cell was significantly increased in the motor skill rats. This appears to parallel the previously reported increase in synapses and associated neuropil volume change.

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Crossref · 10.1038/jcbfm.1992.14

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Research works printed but not linked: 2

  1. Broda! A (1981) Neurological anatomy. New York, Oxford
  2. J Cereb Blood Flow Metab, Vol. 12, No.1, 1992

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Authors
Isaacs, K. R., Anderson, B. J., Alcantara, A. A., Black, J. E., & Greenough, W. T.
Affiliations
University of Illinois Urbana-Champaign (US)
Venue
Journal of Cerebral Blood Flow & Metabolism
Published
1992-01
Volume
12
Issue
1
Pages
110-119
ISSN
  • 0271-678X (ISSN-L)
  • 1559-7016
OpenAlex
W2010856791
Cited by
405
References
62
Citations by year
2026: 3 · 2025: 11 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 11 · 2019: 20 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 17 · 2014: 12 · 2013: 22 · 2012: 22
FWCI
1.43
Type
journal article
Language
en
Open access
Locations
  • Journal of Cerebral Blood Flow & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • National Institutes of Health (5t32mh018412-02)
  • University of Illinois at Urbana-Champaign
  • U.S. Public Health Service (43830)
  • National Institute of Mental Health (MH-18882, MH18412)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD07333, T32HD007333)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
physical activity, angiogenesis, cerebellum, motor skill learning, Purkinje cells, molecular layer, blood vessel density, mitochondrial volume fraction, treadmill running, running wheel, brain vascularization
MeSH terms
Animals, Capillaries, Cerebellum, Physical Exertion, Female, Learning, Motor Skills, Neovascularization, Pathologic, Rats

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