The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Nitrite and Nitrate Are Formed by Endogenous Synthesis in the Human Intestine
Abstract
Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.
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“the endogenous production of nitrate from NO oxidation (mainly via reaction with oxy-hemoglobin) has long been recognized to be an order of magnitude greater than dietary intake as shown in the late 1970s [7] and more recently in studies using eNOS-deficient mice [45].”
From Nitrate reduction to nitrite, nitric oxide and ammonia by gut bacteria under physiological conditions (2015) · cites this paper as [7]
Citations
Cites
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Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten
Druckrey, H., Preußmann, R., Ivankovic, S., Schm�hl, D., Afkham, J., Blum, G., Mennel, H. D., M�ller, M., Petropoulos, P., & Schneider, H. (1967) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00524152 · Cited by 1,349
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Self-citationStudies of Intestinal Microflora
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White, J. W. (1975) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60201a034 · Cited by 267
Nitrite in Human Saliva. Its Possible Relationship to Nitrosamine Formation23
Tannenbaum, S. R., Sinskey, A. J., Weisman, M., & Bishop, W. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.1.79 · Cited by 237
Self-citationGastric Cancer in Colombia. I. Cancer Risk and Suspect Environmental Agents2
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Formation in vivo of volatile N-nitrosamines in man after ingestion of cooked bacon and spinach
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Behavior of the Nitrate Ion in the Dog
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Flagged first, then by citations
Research works printed but not linked: 4
- BRUCE, W.R., ORIGINS HUMAN CANCER: 1641 (1977).
- HILL, M.J., N NITROSO COMPOUNDS: 116 (1972).
- LAURENT, M, ANNALES DE L INSTITUT PASTEUR 121: 795 (1971).
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Cited by
Sorted by citations
Regulatory Functions of the Vascular Endothelium
Epstein, F. H., Vane, J. R., Änggård, E., & Botting, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230106 · Cited by 1,885
Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126
Determination of Inorganic Nitrate in Serum and Urine by a Kinetic Cadmium-Reduction Method
Cortas, N. K., & Wakid, N. W. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.8.1440 · Cited by 894
Inflammation, immunoregulation, and inducible nitric oxide synthase
Nussler, A. K., & Billiar, T. R. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.2.171 · Cited by 859
Isoforms of nitric oxide synthase Characterization and purification from different cell types
Förstermann, U., Schmidt, H. H. H. W., Pollock, J. S., Sheng, H., Mitchell, J. A., Warner, T. D., Nakane, M., & Murad, F. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90581-o · Cited by 817
Metadata
- Authors
- Tannenbaum, S. R., Fett, D., Young, V. R., Land, P. D., & Bruce, W. R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Ontario Cancer Institute, Toronto, Ontario M4X 1K9, Canada
- ORCID
- Tannenbaum, S. R.
- Venue
- Science
- Published
- 1978-06-30
- Volume
- 200
- Issue
- 4349
- Pages
- 1487-1489
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044183185
- Cited by
- 284
- References
- 26
- Citations by year
- 2025: 3 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 6 · 2012: 6
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- nitrite, nitrate, human intestine, heterotrophic nitrification, cancer etiology, ileostomy
- MeSH terms
- Adult, Aged, Dietary Proteins, Feces, Humans, Ileostomy, Intestinal Mucosa, Male, Nitrates, Nitrites
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