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Nitrite and Nitrate Are Formed by Endogenous Synthesis in the Human Intestine
Abstract
Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.
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“the endogenous production of nitrate from NO oxidation (mainly via reaction with oxy-hemoglobin) has long been recognized to be an order of magnitude greater than dietary intake as shown in the late 1970s [7] and more recently in studies using eNOS-deficient mice [45].”
From Nitrate reduction to nitrite, nitric oxide and ammonia by gut bacteria under physiological conditions (2015) · cites this paper as [7]
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Metadata
- Authors
- Tannenbaum, S. R., Fett, D., Young, V. R., Land, P. D., & Bruce, W. R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Ontario Cancer Institute, Toronto, Ontario M4X 1K9, Canada
- ORCID
- Tannenbaum, S. R.
- Venue
- Science
- Published
- 1978-06-30
- Volume
- 200
- Issue
- 4349
- Pages
- 1487-1489
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044183185
- Cited by
- 284
- References
- 26
- Citations by year
- 2025: 3 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 6 · 2012: 6
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- nitrite, nitrate, human intestine, heterotrophic nitrification, cancer etiology, ileostomy
- MeSH terms
- Adult, Aged, Dietary Proteins, Feces, Humans, Ileostomy, Intestinal Mucosa, Male, Nitrates, Nitrites
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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