The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Synthesis of Compounds with Properties of Leukotrienes C 4 and D 4 in Gerbil Brains After Ischemia and Reperfusion
Abstract
6-Sulfidopeptide-containing leukotriene-like immunoreactivity was synthesized in gerbil forebrains after bilateral common carotid occlusion and reperfusion. At 5, 10, or 15 minutes of ischemia, concentrations increased significantly and became more marked on reperfusion. Immunoreactivity was highest in forebrain gray matter and was below the detection limit of the assay in brain regions remote from the zone of ischemia. In vitro experiments with vascular cells and organ cultures of cerebral arteries indicate that the cerebral blood vessel wall is not a major source of biosynthetic activity in the brain. These experiments demonstrate leukotriene biosynthesis by the brain. Because synthesis occurs during ischemia and reperfusion and because leukotrienes are potent vasoconstrictors and promoters of tissue edema, they may play a role in the pathophysiology of cerebral ischemia.
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Cites
Cerebral ischemia. II. The no-reflow phenomenon.
Ames, A., Rl, W., Kowada, M., Thurston, J. M., & Majno, G. (1968) · PubMed · Cited by 1,371
Dahlén, S. E., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3887 · Cited by 1,019
Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain
Bazán, N. G. (1970) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(70)90086-x · Cited by 855
Raff, M., Abney, E., Cohen, J., Lindsay, R., & Noble, M. (1983) · The Journal of Neuroscience · doi:10.1523/jneurosci.03-06-01289.1983 · Cited by 759
Wolfe, L. S. (1982) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1982.tb10847.x · Cited by 573
Structure of slow-reacting substance of anaphylaxis from guinea-pig lung
Morris, H. R., Taylor, G. W., Piper, P. J., & Tippins, J. R. (1980) · Nature · doi:10.1038/285104a0 · Cited by 422
Recovery of brain mitochondrial function in the rat after complete and incomplete cerebral ischemia.
Rehncrona, S., Mela, L., & Siesjö, B. K. (1979) · Stroke · doi:10.1161/01.str.10.4.437 · Cited by 378
Gaudet, R. J., Alam, I., & Levine, L. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb03704.x · Cited by 364
Self-citationBowman, P. D., Ennis, S. R., Rarey, K. E., Lorris Betz, A., & Goldstein, G. W. (1983) · Annals of Neurology · doi:10.1002/ana.410140403 · Cited by 321
Leukotriene D: a slow reacting substance from rat basophilic leukemia cells.
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Cited by
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802
Rodent models of cerebral ischemia.
Ginsberg, M. D., & Busto, R. (1989) · Stroke · doi:10.1161/01.str.20.12.1627 · Cited by 659
Siesjö, B. K. (1992) · Journal of Neurosurgery · doi:10.3171/jns.1992.77.3.0337 · Cited by 657
Mammalian lipoxygenases and their biological relevance
Kuhn, H., Banthiya, S., & van Leyen, K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.002 · Cited by 624
Hydroxyeicosatetraenoic acids (HETEs)
Spector, A. A., Gordon, J. A., & Moore, S. A. (1988) · Progress in Lipid Research · doi:10.1016/0163-7827(88)90009-4 · Cited by 302
Metadata
- Authors
- Moskowitz, M. A., Kiwak, K. J., Hekimian, K., & Levine, L.
- Venue
- Science
- Published
- 1984-05-25
- Volume
- 224
- Issue
- 4651
- Pages
- 886-889
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075673909
- Cited by
- 351
- References
- 22
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Synthesis of Compounds with Properties of Leukotrienes C 4 and D 4 in Gerbil Brains After Ischemia and Reperfusion. https://app.cochat.ai/papers/10.1126/science.6719118
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- Moskowitz, M. A., Kiwak, K. J., Hekimian, K., & Levine, L. (1984). Synthesis of Compounds with Properties of Leukotrienes C 4 and D 4 in Gerbil Brains After Ischemia and Reperfusion. Science. https://doi.org/10.1126/science.6719118
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
