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Leukotriene D 4 : a Potent Coronary Artery Vasoconstrictor Associated with Impaired Ventricular Contraction
Abstract
Leukotriene D 4 (2 × 10 -9 mole), injected into the left circumflex coronary artery of anesthetized sheep, produced profound coronary vasoconstriction and impaired regional ventricular wall motion. This cardiac effect was neither inhibited by prior treatment of the sheep with a cyclooxygenase inhibitor nor associated with thromboxane B 2 release into the coronary sinus. Intravenous FPL 55712 completely abolished the coronary vasoconstriction of leukotriene D 4 , but a significant reduction of regional wall shortening persisted.
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Citations
Cited by
Lewis, R. A., & Austen, K. F. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111312 · Cited by 656
Spanbroek, R., Gräbner, R., Lötzer, K., Hildner, M., Urbach, A., Rühling, K., Moos, M. P. W., Kaiser, B., Cohnert, T. U., Wahlers, T., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242716099 · Cited by 458
Leukotriene modifiers as potential therapeutics for cardiovascular disease
Funk, C. D. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1796 · Cited by 326
International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors
Brink, C., Dahlén, S.-E., Drazen, J., Evans, J. F., Hay, D. W. P., Nicosia, S., Serhan, C. N., Shimizu, T., & Yokomizo, T. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.8 · Cited by 286
Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke
Rink, C., & Khanna, S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3474 · Cited by 233
Metadata
- Authors
- Michelassi, F., Landa, L., Hill, R. D., Lowenstein, E., Watkins, W. D., Petkau, A. J., & Zapol, W. M.
- Venue
- Science
- Published
- 1982-08-27
- Volume
- 217
- Issue
- 4562
- Pages
- 841-843
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967314154
- Cited by
- 217
- References
- 0
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Leukotriene D 4 : a Potent Coronary Artery Vasoconstrictor Associated with Impaired Ventricular Contraction. https://app.cochat.ai/papers/10.1126/science.6808665
- The paper
- Michelassi, F., Landa, L., Hill, R. D., Lowenstein, E., Watkins, W. D., Petkau, A. J., & Zapol, W. M. (1982). Leukotriene D 4 : a Potent Coronary Artery Vasoconstrictor Associated with Impaired Ventricular Contraction. Science. https://doi.org/10.1126/science.6808665
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
