The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology.
Open accessAbstract
Tbiological activity of one major class of leukotrienes, originally described as slow reacting substance of anaphylaxis (SRS-A)' (1, 2) and now known to be composed of the sulfidopeptide leukotrienes, 5S-hydroxy-6R-S-glutathionyl-7,9-trans-I 1, 14-cis-eicosatetraenoic acid (leukotriene C4, LTC4), 5S-hydroxy-6R-S-cysteinylglycyl-7,9-trans-11, 14-cis-eicosa- tetraenoic acid (leukotriene D4, LTD4), and 5S-hydroxy-6R-Scysteinyl-7,9-trans-1 1, 14-cis-eicosatetraenoic acid (leukotriene E4, LTE4) (3-7), has been known for over 40 years.The biological activity and structure of the second major class of leukotrienes, represented solely by 5S-12R-dihydroxy-6,14-cis-8, I0-trans- eicosatetraenoic acid (leukotriene B4, LTB4), was recognized only 5 years ago (8-11).On the basis of the earlier definition of SRS-A in terms ofchromatographic, functional, and chemical characteristics (12-15), it was possible to generate a similar material with radiolabeled constituents by ionophore activation of mouse mastocytoma cells and to achieve a chemical characterization of LTC4 (3).The stereospecific synthesis of both LTC4 (16) and LTB4 (17) has now permitted the delineation of the common and separate enzymes in the pathways for biosynthesis of LTC4 and LTB4 from arachidonic acid (reviewed Receivedfor publication I December 1983.1. Abbreviations used in this paper: 5-HPETE, 5S-hydroperoxy-6-trans-8,1 1,14-cis-eicosatetraenoic acid; LTA4, 5,6-trans-oxido-7,9-trans-1 1,14cis-eicosatetraenoic acid; LTB4, 5S-12R-dihydroxy-6,14-cis-8, 10-transeicosatetraenoic acid; LTC4, 5S-hydroxy-6R-S-glutathionyl-7,9-trans-1 1,14-cis-eicosatetraenoic acid; LTD4, 5S-hydroxy-6R-S-cysteinylglycyl- 7,9-trans-I 1,14-cis-eicosatetraenoic acid; LTE4, 5S-hydroxy-6R-S-cysteinyl-7,9-trans-1 1, 14-cis-eicosatetraenoic acid; LTB5, 5,12-dihydroxy-6,8,10,14,17-eicosapentaenoic acid; LTC5, 5-hydroxy-6-S-glutathionyl-7,9-trans-i 1,14,17-cis-eicosapentaenoic acid; PMN, peripheral blood polymorphonuclear neutrophilic leukocytes; RP-HPLC, reverse phasehigh performance liquid chromatography; SRS-A, slow reacting substance of anaphylaxis.
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Cites
Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation
Samuelsson, B. (1983) · Science · doi:10.1126/science.6301011 · Cited by 2,843
Ford-Hutchinson, A. W., Bray, M. A., Doig, M. V., Shipley, M. E., & Smith, M. J. H. (1980) · Nature · doi:10.1038/286264a0 · Cited by 2,060
Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets
Hamberg, M., & Samuelsson, B. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.9.3400 · Cited by 1,407
Prostaglandins and Thromboxanes
Samuelsson, B., Goldyne, M., Granström, E., Hamberg, M., Hammarström, S., & Malmsten, C. (1978) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.47.070178.005025 · Cited by 1,299
Dahlén, S. E., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3887 · Cited by 1,019
Leukotriene C: a slow-reacting substance from murine mastocytoma cells.
Murphy, R. C., Hammarström, S., & Samuelsson, B. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.9.4275 · Cited by 991
Advances in prostaglandin, thromboxane, and leukotriene research
早石, 修., & 山本, 尚. (1985) · Raven Press eBooks · Cited by 798
Diglyceride lipase: a pathway for arachidonate release from human platelets.
Bell, R. L., Kennerly, D. A., Stanford, N., & Majerus, P. W. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3238 · Cited by 687
Borgeat, P., & Samuelsson, B. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30120-5 · Cited by 648
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Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Lee, T. H., Hoover, R. L., Williams, J. D., Sperling, R. I., Ravalese, J., Spur, B. W., Robinson, D. R., Corey, E. J., Lewis, R. A., & Austen, K. F. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121903 · Cited by 1,333
Self-citationLewis (1990) · doi:10.1056/nejm199009063231006 · Cited by 1,200
Kinsella, J., Lokesh, B., & Stone, R. (1990) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.1.1 · Cited by 718
Metadata
- Authors
- Lewis, R. A., & Austen, K. F.
- Venue
- Journal of Clinical Investigation
- Published
- 1984-04-01
- Volume
- 73
- Issue
- 4
- Pages
- 889-897
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2065234246
- Cited by
- 656
- References
- 55
- FWCI
- 37.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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