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Cited by 458

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

Open access
Spanbroek, Rainer, Gräbner, Rolf, Lötzer, Katharina, Hildner, Markus, Urbach, Anja, Rühling, Katharina, Moos, Michael P. W., Kaiser, Brigitte, Cohnert, Tina U., Wahlers, Thorsten, Zieske, Arthur, Plenz, Gabriele, Robenek, Horst, Salbach, Peter, Kühn, Hartmut, Rådmark, Olof, Samuelsson, Bengt, Habenicht, Andreas J. R.·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.242716099
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Abstract

Oxidation products of low-density lipoproteins have been suggested to promote inflammation during atherogenesis, and reticulocyte-type 15-lipoxygenase has been implicated to mediate this oxidation. In addition, the 5-lipoxygenase cascade leads to formation of leukotrienes, which exhibit strong proinflammatory activities in cardiovascular tissues. Here, we studied both lipoxygenase pathways in human atherosclerosis. The 5-lipoxygenase pathway was abundantly expressed in arterial walls of patients afflicted with various lesion stages of atherosclerosis of the aorta and of coronary and carotid arteries. 5-lipoxygenase localized to macrophages, dendritic cells, foam cells, mast cells, and neutrophilic granulocytes, and the number of 5-lipoxygenase expressing cells markedly increased in advanced lesions. By contrast, reticulocyte-type 15-lipoxygenase was expressed at levels that were several orders of magnitude lower than 5-lipoxygenase in both normal and diseased arteries, and its expression could not be related to lesion pathology. Our data support a model of atherogenesis in which 5-lipoxygenase cascade-dependent inflammatory circuits consisting of several leukocyte lineages and arterial wall cells evolve within the blood vessel wall during critical stages of lesion development. They raise the possibility that antileukotriene drugs may be an effective treatment regimen in late-stage disease.

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Metadata

Authors
Spanbroek, R., Gräbner, R., Lötzer, K., Hildner, M., Urbach, A., Rühling, K., Moos, M. P. W., Kaiser, B., Cohnert, T. U., Wahlers, T., Zieske, A., Plenz, G., Robenek, H., Salbach, P., Kühn, H., Rådmark, O., Samuelsson, B., & Habenicht, A. J. R.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2003-01-27
Volume
100
Issue
3
Pages
1238-1243
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.242716099
OpenAlex
W2032255457
Cited by
458
References
53
FWCI
11.86
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. https://app.cochat.ai/papers/10.1073/pnas.242716099
The paper
Spanbroek, R., Gräbner, R., Lötzer, K., Hildner, M., Urbach, A., Rühling, K., Moos, M. P. W., Kaiser, B., Cohnert, T. U., Wahlers, T., Zieske, A., Plenz, G., Robenek, H., Salbach, P., Kühn, H., Rådmark, O., Samuelsson, B., & Habenicht, A. J. R. (2003). Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.242716099

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.