The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Choline and Cholinergic Neurons
Abstract
Mammalian neurons can synthesize choline by methylating phosphatidylethanolamine and hydrolyzing the resulting phosphatidylcholine. This process is stimulated by catecholamines. The phosphatidylethanolamine is synthesized in part from phosphatidylserine; hence the amino acids methionine (acting after conversion to S -adenosylmethionine) and serine can be the ultimate precursors of choline. Brain choline concentrations are generally higher than plasma concentrations, but depend on plasma concentrations because of the kinetic characteristics of the blood-brain-barrier transport system. When cholinergic neurons are activated, acetylcholine release can be enhanced by treatments that increase plasma choline (for example, consumption of certain foods).
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Citations
Cites
Hirsch, M. J., Growdon, J. H., & Wurtman, R. J. (1978) · Metabolism · doi:10.1016/0026-0495(78)90139-7 · Cited by 95
Self-citation
Cited by
Choline: Critical Role During Fetal Development and Dietary Requirements in Adults
Zeisel, S. H. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111156 · Cited by 741
Behavioral effects of dietary neurotransmitter precursors: Basic and clinical aspects
Young, S. N. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00022-4 · Cited by 86
Glycerophosphocholine enhances growth hormone secretion and fat oxidation in young adults
Kawamura, T., Okubo, T., Sato, K., Fujita, S., Goto, K., Hamaoka, T., & Iemitsu, M. (2012) · Nutrition · doi:10.1016/j.nut.2012.02.011 · Cited by 66
The Effects of Choline Supplementation on Physical Performance
Warber, J. P., Patton, J. F., Tharion, W. J., Zeisel, S. H., Mello, R. P., Kemnitz, C. P., & Lieberman, H. R. (2000) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.10.2.170 · Cited by 47
Neurotransmitter-precursor-supplement intervention for detoxified heroin addicts
Chen, D., Liu, Y., He, W., Wang, H., & Wang, Z. (2012) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-012-0073-z · Cited by 47
Metadata
- Authors
- Blusztajn, J. K., & Wurtman, R. J.
- Venue
- Science
- Published
- 1983-08-12
- Volume
- 221
- Issue
- 4611
- Pages
- 614-620
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071780639
- Cited by
- 443
- References
- 1
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blusztajn, J. K., & Wurtman, R. J. (1983). Choline and Cholinergic Neurons. Science. https://doi.org/10.1126/science.6867732
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
