Behavioral effects of dietary neurotransmitter precursors: Basic and clinical aspects

Young, Simon N.

doi:10.1016/0149-7634(95)00022-4

Cited by 86Tryptophan and brain disordersNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Behavioral effects of dietary neurotransmitter precursors: Basic and clinical aspects

Young, Simon N.·1996·Neuroscience & Biobehavioral Reviews

DOI 10.1016/0149-7634(95)00022-4

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Abstract

The levels and possibly function of several neurotransmitters can be influenced by the supply of their dietary precursors. The neurotransmitters include serotonin, dopamine, noradrenaline, histamine, acetylcholine and glycine, which are formed from tryptophan, tyrosine, histidine, choline and threonine. Tryptophan has been tested more than the other precursors in clinical trials and is currently available in some countries for the treatment of depression. Other uses for tryptophan and the therapeutic potential of other neurotransmitter precursors have not been tested adequately. Given the relative lack of toxicity of dietary components, further clinical trials with neurotransmitter precursors should be carried out.

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Selective increases in tyrosine intake may benefit aspects of human behavior and cognition that are under catecholaminergic control.
“In short, selective increases in the intake of tyrosine may benefit those aspects of human behavior and cognition that are under the catecholaminergic control (Young, 1996).”
From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Young, 1996
The side effects of tyrosine appear milder and less frequent than those of methylphenidate, though toxicity data on long-term use are lacking.
“At the same time, the side effects of tyrosine appear to be milder and less frequent (Young, 1996) than those of methylphenidate (Linssen et al., 2014), though toxicity data on their long-term use are lacking.”
From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Young, 1996
The quality of the reviewed studies was better than that of the case studies and mostly uncontrolled studies previously described by Young (1996).
“This suggests that their quality was better than that of the case studies and mostly uncontrolled studies previously described by Young (1996).”
From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Young, 1996

The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545 · see citing works
Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020 · see citing works
Advances in Pain Research and Therapy
Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,263 · see citing works
Psychopharmacology: The Third Generation of Progress.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-509_2 · Cited by 2,021 · see citing works
Handbook of Neurochemistry
Lajtha, Á. (1972) · Springer eBooks · doi:10.1007/978-1-4615-7172-8 · Cited by 1,373 · see citing works
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
Fernstrom, J. D., & Wurtman, R. J. (1971) · Science · doi:10.1126/science.173.3992.149 · Cited by 1,017 · see citing works
Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials
Muldoon, M. F., Manuck, S. B., & Matthews, K. A. (1990) · BMJ · doi:10.1136/bmj.301.6747.309 · Cited by 960 · see citing works
Raphe unit activity in freely moving cats: correlation with level of behavioral arousal.
Trulson, M., & Jacobs, B. (1979) · Brain Research · doi:10.1016/0006-8993(79)90157-4 · Cited by 815 · see citing works
Precursor control of neurotransmitter synthesis.
Wurtman, R. J., Hefti, F. F., & Melamed, E. (1980) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06841-3 · Cited by 674 · see citing works
Serotonin and appetite
Blundell, J. E. (1984) · Neuropharmacology · doi:10.1016/0028-3908(84)90098-4 · Cited by 579 · see citing works
Advances in pain research and therapy
Flor, H. (2007) · European Psychiatry · doi:10.1016/j.eurpsy.2007.01.042 · Cited by 548 · see citing works
Choline and Cholinergic Neurons
Blusztajn, J. K., & Wurtman, R. J. (1983) · Science · doi:10.1126/science.6867732 · Cited by 443 · see citing works
Is the histaminergic neuron system a regulatory center for whole-brain activity?
Wada, H., Inagaki, N., Yamatodani, A., & Watanabe, T. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90034-r · Cited by 380 · see citing works
An Investigation of the Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan Use
Belongia, E. A., Hedberg, C. W., Gleich, G. J., White, K. E., Mayeno, A. N., Loegering, D. A., Dunnette, S. L., Pirie, P. L., MacDonald, K. L., & Osterholm, M. T. (1990) · New England Journal of Medicine · doi:10.1056/nejm199008093230601 · Cited by 356 · see citing works
POTENTIATION OF THE ANTIDEPRESSIVE EFFECT OF A MONOAMINE-OXIDASE INHIBITOR BY TRYPTOPHAN
Coppen, A. J., Shaw, D., & Farrell, J. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91084-5 · Cited by 345 · see citing works
Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino-acids in rat brain
Carlsson, A., & Lindqvist, M. (1978) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/bf00508062 · Cited by 326 · see citing works
L-Tryptophan in Mania
Prange, A. J. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760070040006 · Cited by 275 · see citing works
Neuropharmacology of the histaminergic neuron system in the brain and its relationship with behavioral disorders
Onodera, K., Yamatodani, A., Watanabe, T., & WADAS, H. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90017-5 · Cited by 242 · see citing works
Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans
Banderet, L. E., & Lieberman, H. R. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90096-8 · Cited by 213 · see citing works
Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys.
Kaplan, J. R., Shively, C. A., Fontenot, M. B., Morgan, T. M., Howell, S. M., Manuck, S. B., Muldoon, M. F., & Mann, J. J. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199411000-00001 · Cited by 206 · see citing works
Effects of protein and carbohydrate meals on mood and performance: Interactions with sex and age
Spring, B. J., Maller, O., Wurtman, J. J., Digman, L., & Cozolino, L. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90017-6 · Cited by 200 · see citing works
Dopamine and the Pathophysiology of Dyskinesias Induced by Antipsychotic Drugs
Baldessarini, R. J., & Tarsy, D. (1980) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.03.030180.000323 · Cited by 198 · see citing works
Progress in Tryptophan and Serotonin Research
(1984) · De Gruyter eBooks · doi:10.1515/9783111641546 · Cited by 185 · see citing works
Pain measurement in man — Neurophysiological correlates of pain
Buruma, O. J. S. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90194-7 · Cited by 180 · see citing works
The treatment of depression in general practice: a comparison of L-tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo
Thomson, J., Rankin, H., Ashcroft, G. W., Yates, C. M., McQueen, J. K., & Cummings, S. W. (1982) · Psychological Medicine · doi:10.1017/s0033291700049047 · Cited by 177 · see citing works
Neurochemical and behavioral consequences of acute, uncontrollable stress: Effects of dietary tyrosine
Lehnert, H., Reinstein, D. K., Strowbridge, B. W., & Wurtman, R. J. (1984) · Brain Research · doi:10.1016/0006-8993(84)91207-1 · Cited by 170 · see citing works
Potentiation of a monoamine oxidase inhibitor by tryptophan
Glassman, A. H., & Platman, S. R. (1969) · Journal of Psychiatric Research · doi:10.1016/0022-3956(69)90013-2 · Cited by 169 · see citing works
Carbohydrate craving in obese people: Suppression by treatments affecting serotoninergic transmission
Wurtman, J. J., Wurtman, R. J., Growdon, J. H., Henry, P., Lipscomb, A., & Zeisel, S. H. (1981) · International Journal of Eating Disorders · doi:10.1002/1098-108x(198123)1:1 · Cited by 165 · see citing works
POTENTIATION OF MONOAMINE-OXIDASE INHIBITORS BY TRYPTOPHAN
Pare, C. M. B. (1963) · The Lancet · doi:10.1016/s0140-6736(63)90271-x · Cited by 163 · see citing works
The relationship of alpha and delta EEG frequencies to pain and mood in ‘fibrositis’ patients treated with chlorpromazine and l-tryptophan
Moldofsky, H., & Lue, F. A. (1980) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(80)90324-7 · Cited by 163 · see citing works
Effect of tryptophan administration on tryptophan, 5-hydroxyindoleacetic acid and indoleacetic acid in human lumbar and cisternal cerebrospinal fluid.
Young, S. N., & Gauthier, S. G. (1981) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.44.4.323 · Cited by 159 · see citing works
Self-citation
Oral Choline Administration to Patients with Tardive Dyskinesia
Growdon, J. H., Hirsch, M. J., Wurtman, R. J., & Wiener, W. B. (1977) · New England Journal of Medicine · doi:10.1056/nejm197709082971002 · Cited by 158 · see citing works
Management of depression with serotonin precursors.
van Praag, H. M. (1981) · PubMed · Cited by 153 · see citing works
Tyrosine reverses a cold-induced working memory deficit in humans
Shurtleff, D., Thomas, J. R., Schrot, J., Kowalski, K., & Harford, R. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90299-2 · Cited by 142 · see citing works
Lecithin and Choline in Human Health and Disease
Canty, D. J., & Zeisel, S. H. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1994.tb01357.x · Cited by 137 · see citing works
Effect of tryptophan administration on 5HIAA in cerebrospinal fluid in man.
ECCLESTON, D., Ashcroft, G. P., & Crawford, T. B. B. (1970) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.33.2.269 · Cited by 137 · see citing works
DYNAMICS OF THE REGULATION OF HISTAMINE LEVELS IN MOUSE BRAIN1
Taylor, K. M., & Snyder, S. H. (1972) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1972.tb01344.x · Cited by 135 · see citing works
Diet-induced mood changes in normal populations
Leathwood, P. D., & Pollet, P. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90016-4 · Cited by 131 · see citing works
Cholinomimetic and anticholinergic drugs used to investigate an acetylcholine hypothesis of affective disorders and stress
Janowsky, D. S., & Risch, S. C. (1984) · Drug Development Research · doi:10.1002/ddr.430040202 · Cited by 126 · see citing works
Mood, performance, and pain sensitivity: Changes induced by food constituents
Lieberman, H. R., Suzanne Corkin, A., Spring, B. J., Growdon, J. H., & Wurtman, R. J. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90015-2 · Cited by 123 · see citing works
Serotonin and pain
Brandão, M. L. (1991) · Cited by 117 · see citing works
Pain measurement in man : neurophysiological correlates of pain
Bromm, B. (1984) · Elsevier eBooks · Cited by 116 · see citing works
Effect of tyrosine on cognitive function and blood pressure under stress.
Deijen, J., & Orlebeke, J. F. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90200-3 · Cited by 116 · see citing works
l-Tryptophan in affective disorders: Indoleamine changes and differential clinical effects
Murphy, D. L., Baker, M., Goodwin, F. K., Miller, H., Kotin, J., & Bunney, W. E. (1974) · Psychopharmacology · doi:10.1007/bf00421216 · Cited by 112 · see citing works
Clinical response of aggressive schizophrenics to oral tryptophan.
Morand, C., Young, S. N., & Fr, E. (1983) · PubMed · Cited by 105 · see citing works
Self-citation
Changes in Brain Levels of Acidic, Basic, and Neutral Amino Acids After Consumption of Single Meals Containing Various Proportions of Protein
Glaeser, B. S., Maher, T. J., & Wurtman, R. J. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb09045.x · Cited by 100 · see citing works
Catecholamine synthesis: Physiological coupling to precursor supply
Milner, J. D., & Wurtman, R. J. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90071-7 · Cited by 99 · see citing works
Observations on Schizophrenic Patients After Iproniazid and Tryptophan
Lauer, J. W. (1958) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1958.02340070140021 · Cited by 97 · see citing works
The clinical psychopharmacology of tryptophan
Young, S. N. (1986) · Cited by 93 · see citing works
Self-citation
The Influence of Intravenous L-Tryptophan on Plasma Melatonin and Sleep in Men
Hajak, G., Huether, G., Blanke, J., Blömer, M., Freyer, C., Pöeggeler, B., Reimer, A., Rodenbeck, A., Schulz-Varszegi, M., & Rüther, E. (1991) · Pharmacopsychiatry · doi:10.1055/s-2007-1014427 · Cited by 91 · see citing works
Effects of oral L-tyrosine administration of CSF tyrosine and homovanillic acid levels in patients with Parkinson's disease
Growdon, J. H., Melamed, E., Logue, M., Hefti, F., & Wurtman, R. J. (1982) · Life Sciences · doi:10.1016/0024-3205(82)90596-3 · Cited by 91 · see citing works
Cholinergic influences in tardive dyskinesia
Tamminga, C. A., Smith, R. C., Ericksen, S. E., Chang, S., & Davis, J. M. (1977) · American Journal of Psychiatry · doi:10.1176/ajp.134.7.769 · Cited by 91 · see citing works
Choline for Tardive Dyskinesia
Davis, K. L., Berger, P. A., & Hollister, L. E. (1975) · New England Journal of Medicine · doi:10.1056/nejm197507172930317 · Cited by 89 · see citing works
The Cause and Pathogenesis of the Eosinophilia-Myalgia Syndrome
Varga, J., Uitto, J., & Jiménez, S. A. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-2-140 · Cited by 84 · see citing works
Behavioral effects and brain amine content in rats.
Sm, H., & Doepfner, W. (1961) · PubMed · Cited by 84 · see citing works
Effect of Precursor Loading on the Synthesis Rate and Release of Dopamine and Serotonin in the Striatum: A Microdialysis Study in Conscious Rats
Westerink, B. H. C., & Vries, J. B. D. (1991) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1991.tb02585.x · Cited by 77 · see citing works
L-deprenyl plus l-phenylalanine in the treatment of depression
Birkmayer, W., Riederer, P. F., Linauer, W., & Knoll, J. E. (1984) · Journal of Neural Transmission · doi:10.1007/bf01249880 · Cited by 74 · see citing works
Hypnotic Effects of L-Tryptophan
Hartmann, E. L. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760150098014 · Cited by 74 · see citing works
Lecithin in the treatment of mania: double-blind, placebo-controlled trials
Cohen, B. M., Lipinski, J. F., & Altesman, R. I. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.9.1162 · Cited by 74 · see citing works
Tyrosine for depression: a double-blind trial
Gelenberg, A. J., Wojcik, J. D., Falk, W. E., Baldessarini, R. J., Zeisel, S. H., Schoenfeld, D., & Mok, G. S. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90017-3 · Cited by 71 · see citing works
Effect of acute administration of L-tryptophan on the release of 5-HT in rat hippocampus in relation to serotoninergic neuronal activity: An microdialysis study
Sharp, T., Bramwell, S., & Smith, A. D. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90321-f · Cited by 71 · see citing works
Effects of L-tryptophan on short term food intake in lean men
Hrboticky, N., Leiter, L. A., & Anderson, G. H. (1985) · Nutrition Research · doi:10.1016/s0271-5317(85)80240-2 · Cited by 69 · see citing works
Biologic Correlates of Suicidal Risk and Aggressive Behavioral Traits
Linnoila, M., & Virkkunen, M. E. (1992) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199204001-00004 · Cited by 69 · see citing works
Alteration of human pain thresholds by nutritional manipulation and l-tryptophan supplementation
Seltzer, S., Stoch, R., Marcus, R., & Jackson, E. (1982) · Pain · doi:10.1016/0304-3959(82)90007-0 · Cited by 68 · see citing works
The effect of L-tryptophan on seasonal affective disorder.
McGrath, R. E., Buckwald, B., & Resnick, E. V. (1990) · PubMed · Cited by 65 · see citing works
Emerging Treatments: Replacement Therapy with Choline or Lecithin in Neurological Diseases
Barbeau, A. (1978) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100024963 · Cited by 62 · see citing works
Neurotransmitter precursors for the treatment of depression.
Gelenberg, A. J., Gibson, C. J., & Wojcik, J. (1982) · PubMed · Cited by 61 · see citing works
Choline and lecithin in the treatment of tardive dyskinesia: preliminary results from a pilot study
Gelenberg, A. J., DOLLER-WOJCIK, J. C., & Growdon, J. H. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.6.772 · Cited by 61 · see citing works
Improved Cholesterol-Related Knowledge and Behavior and Plasma Cholesterol Levels in Adults During the 1980s
Frank, E. (1992) · JAMA · doi:10.1001/jama.1992.03490120080032 · Cited by 61 · see citing works
Treatment of attention deficit disorder with DL-phenylalanine
Wood, D. R., Reimherr, F. W., & Wender, P. H. (1985) · Psychiatry Research · doi:10.1016/0165-1781(85)90024-1 · Cited by 61 · see citing works
Dose-response relationships between systemically administered l-tryptophan or l-5-hydroxytryptophan and raphe unit activity in the rat
Trulson, M. E., & Jacobs, B. (1976) · Neuropharmacology · doi:10.1016/0028-3908(76)90080-0 · Cited by 60 · see citing works
Tryptophan and an MAOI (Nialamide) in the Treatment of Depression
Jl, A. G., & Alino, J. J. L.-I. (2017) · International Pharmacopsychiatry · doi:10.1159/000468258 · Cited by 60 · see citing works
Brief Report
Ladd, S. L., Sommer, S. A., LaBerge, S. P., & Toscano, W. B. (1993) · Clinical Neuropharmacology · doi:10.1097/00002826-199312000-00007 · Cited by 59 · see citing works
Tryptophan treatment of aggressive psychiatric inpatients
Volavka, J., Crowner, M. L., Brizer, D. A., Convit, A. J., van Praag, H. M., & Suckow, R. F. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90459-f · Cited by 57 · see citing works
The effects of dietary tryptophan on chronic maxillofacial pain and experimental pain tolerance
Seltzer, S., Dewart, D., Pollack, R. L., & Jackson, E. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90020-6 · Cited by 56 · see citing works
Clinical studies on the phenylethylamine hypothesis of affective disorder: urine and blood phenylacetic acid and phenylalanine dietary supplements.
SABELLI, H. C., Fawcett, J., Gusovsky, F., Javaid, J. I., Wynn, P., Edwards, J., Jeffriess, H., & Kravitz, H. M. (1986) · PubMed · Cited by 55 · see citing works
Calcium‐Dependent, Tetrodotoxin‐Sensitive Stimulation of Cortical Serotonin Release After a Tryptophan Load
Carboni, E., Cadoni, C., Tanda, G., & Chiara, G. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb11802.x · Cited by 54 · see citing works
Choline for Tardive Dyskinesia
Weiss, K. J. (1977) · New England Journal of Medicine · doi:10.1056/nejm197712012972215 · Cited by 52 · see citing works
A controlled clinical trial of l-tryptophan in acute mania
Chouinard, G., Young, S. N., & Annable, L. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90026-5 · Cited by 51 · see citing works
Self-citation
Behavioral and neurochemical effects of dietary tyrosine in young and aged mice following cold-swim stress
Brady, K., Brown, J. W., & Thurmond, J. B. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90146-x · Cited by 49 · see citing works
Acute Effect of Protein or Carbohydrate Breakfasts on Human Cerebrospinal Fluid Monoamine Precursor and Metabolite Levels
Teff, K. L., Young, S. N., Marchand, L., & Botez, M. I. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb10922.x · Cited by 49 · see citing works
Self-citation
Treatment of tardive dyskinesia with lecithin
Jackson, I. V., Ea, N., Ibe, I. O., & Pérez-Cruet, J. (1979) · American Journal of Psychiatry · doi:10.1176/ajp.136.11.1458 · Cited by 48 · see citing works
Treatment of depression by altering monoamine metabolism: precursors and metabolic inhibitors.
Rj, B. (1984) · PubMed · Cited by 47 · see citing works
Tyrosine and its potential use as a countermeasure to performance decrement in military sustained operations.
Owasoyo, J. O., Neri, D. F., & Lamberth, J. (1992) · PubMed · Cited by 46 · see citing works
Pain and tryptophan
King, R. B. (1980) · Journal of neurosurgery · doi:10.3171/jns.1980.53.1.0044 · Cited by 45 · see citing works
Detection of free D ‐amino acids in food by chiral phase capillary gas chromatography
Brückner, H. J., & Hausch, M. (1989) · Journal of High Resolution Chromatography · doi:10.1002/jhrc.1240121012 · Cited by 41 · see citing works
Use of tryptophan in combination with other antidepressant treatments: a review.
Young, S. N. (1991) · PubMed · Cited by 38 · see citing works
Self-citation
L-threonine administration increases glycine concentrations in the rat central nervous system
Maher, T. J., & Wurtman, R. J. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90086-7 · Cited by 38 · see citing works
An Antispasticity Effect of Threonine in Multiple Sclerosis
Hauser, S. L., Doolittle, T. H., Lopez-Bresnahan, M. V., Shahani, B. T., Schoenfeld, D., Shih, V. E., Growdon, J. H., & Lehrich, J. R. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530330045014 · Cited by 38 · see citing works
Short-term Effects of Feed Composition on Sleeping and Crying in Newborns
Oberlander, T. F., Barr, R. G., Young, S. N., & Brian, J. A. (1992) · PEDIATRICS · doi:10.1542/peds.90.5.733 · Cited by 37 · see citing works
Self-citation
Prospective Trial of L-tryptophan in Maternity Blues
Harris, B. (1980) · The British Journal of Psychiatry · doi:10.1192/bjp.137.3.233 · Cited by 36 · see citing works
Degradation of Endogenous Opioids???Its Relevance in Human Pathology and Therapy
Tabatabai, M. (1984) · Anesthesia & Analgesia · doi:10.1213/00000539-198405000-00026 · Cited by 35 · see citing works
Dl-phenylalanine in depressed patients: An open study
Beckmann, H., Strauss, M. A., & Ludolph, E. (1977) · Journal of Neural Transmission · doi:10.1007/bf01670277 · Cited by 35 · see citing works
Biosynthesis of rapidly labeled RNA in brain cells
Egyházi, E., & Hydén, H. (1966) · Life Sciences · doi:10.1016/0024-3205(66)90043-9 · Cited by 34 · see citing works
Exogenous tyrosine potentiates the methylphenidate-induced increase in extracellular dopamine in the nucleus accumbens: a microdialysis study
Woods, S. K., & Meyer, J. S. (1991) · Brain Research · doi:10.1016/0006-8993(91)91220-u · Cited by 32 · see citing works
L-Threonine in the Treatment of Spasticity
Growdon, J. H., Nader, T. M. A., Schoenfeld, J., & Wurtman, R. J. (1991) · Clinical Neuropharmacology · doi:10.1097/00002826-199110000-00003 · Cited by 31 · see citing works
Psychopharmacology Update
FANN, W. E. (1981) · American Journal of Psychiatry · doi:10.1176/ajp.138.5.714 · Cited by 31 · see citing works
L-TYROSINE IN DEPRESSION
Goldberg, I. (1980) · The Lancet · doi:10.1016/s0140-6736(80)90356-6 · Cited by 30 · see citing works
Tryptophan increases extracellular serotonin in the lateral hypothalamus of food-deprived rats
Schwartz, D. H., Hernandez, L., & Hoebel, B. G. (1990) · Brain Research Bulletin · doi:10.1016/0361-9230(90)90174-x · Cited by 30 · see citing works
Effects of Dietary Fatty Acid Composition on Macronutrient Selection and Synaptosomal Fatty Acid Composition in Rats
McGee, C. D., & Greenwood, C. E. (1989) · Journal of Nutrition · doi:10.1093/jn/119.11.1561 · Cited by 29 · see citing works
Effect of choline on basal and stimulated acetylcholine release: an in vivo microdialysis study using a low neostigmine concentration
Marshall, D. L., & Wurtman, R. J. (1993) · Brain Research · doi:10.1016/0006-8993(93)91330-u · Cited by 28 · see citing works
Stereospecificity of phenylalanine plasma kinetics and hydroxylation in man following oral application of a stable isotope-labelled pseudo-racemic mixture of l- and d-phenylalanine
Lehmann, W. D., Theobald, N., Fischer, R., & Heinrich, H. C. (1983) · Clinica Chimica Acta · doi:10.1016/0009-8981(83)90319-4 · Cited by 26 · see citing works
Tryptophan and Human Sleep: An Analysis of 43 Studies
Hartmann, E. L., & Greenwald, D. (1984) · De Gruyter eBooks · doi:10.1515/9783111641546-039 · Cited by 25 · see citing works
Tryptophan-morphine interactions and postoperative pain
Franklin, K. B. J., Abbott, F. V., English, M. J. M., Jeans, M. E., Tasker, R. A., & Young, S. N. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90221-3 · Cited by 24 · see citing works
Self-citation
Effect of 6R-l-erythro-5,6,7,8-tetrahydrobiopterin on the extracellular levels of dopamine and serotonin in the rat striatum: a microdialysis study with tyrosine or tryptophan infusion
Tsukada, H., Lindner, K., Hartvig, P., & m, B. L. N. (1994) · Brain Research · doi:10.1016/0006-8993(94)91423-0 · Cited by 24 · see citing works
Neuronutrient effects on weight loss in carbohydrate bingers: an open clinical trial.
Blum, K., Trachtenberg, M. C., & Cook, D. (1990) · Current Therapeutic Research · Cited by 23 · see citing works
dl-Phenylalanine versus imipramine: A double-blind controlled study
Beckmann, H., Athen, D., Olteanu, M., & Zimmer, R. (1979) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00585677 · Cited by 22 · see citing works
Analgesic effectiveness of D-phenylalanine in chronic pain patients.
Walsh, N. E., Ramamurthy, S., Schoenfeld, L. S., & Hoffman, J. (1986) · PubMed · Cited by 21 · see citing works
Lecithin in the treatment of tardive dyskinesia.
Branchey, M. H., Branchey, L., Nm, B., & Ma, R. (1979) · PubMed · Cited by 21 · see citing works
Role of Amino Acids in Appetite Control in Man
Hill, A. J., & Blundell, J. E. (1988) · Springer eBooks · doi:10.1007/978-3-642-73175-4_21 · Cited by 20 · see citing works
D-phenylalanine in endogenous depression
Mann, J. J., Peselow, E. D., Snyderman, S. E., & Gershon, S. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.12.1611 · Cited by 20 · see citing works
Testmeal Responses Following m-Chlorophenylpiperazine and L-Tryptophan in Bulimics and Controls
Brewerton, T. D., Murphy, D. L., & Jimerson, D. C. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.36 · Cited by 19 · see citing works
Chronic dietary tyrosine supplements do not affect mild essential hypertension.
Sole, M. J., Benedict, C. R., Myers, M. G., Leenen, F. H. H., & Anderson, G. H. (1985) · Hypertension · doi:10.1161/01.hyp.7.4.593 · Cited by 19 · see citing works
Amino acids in psychiatric disease
RICHARDSON, M. A. (1990) · American Psychiatric Press eBooks · Cited by 18 · see citing works
Eosinophilia-myalgia syndrome
Wilkins, K., & Wigle, D. T. (2004) · Springer eBooks · doi:10.1007/3-540-29668-9_926 · Cited by 18 · see citing works
The effect of tryptophan supplementation on autotomy induced by nerve lesions in rats
Abbott, F. V., & Young, S. N. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90557-i · Cited by 17 · see citing works
Self-citation
A Controlled Trial of L-Tryptophan in Mania
Chambers, C. A., & Naylor, G. J. (1978) · The British Journal of Psychiatry · doi:10.1192/bjp.132.6.555 · Cited by 17 · see citing works
Mania responsive to lecithin in a 13-year-old girl
Schreier, H. A. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.1.108 · Cited by 17 · see citing works
The Significance of Tryptophan, Phenylalanine, Tyrosine, and Their Metabolites in the Nervous System
Young, S. N. (1983) · Springer eBooks · doi:10.1007/978-1-4684-4367-7_20 · Cited by 15 · see citing works
Self-citation
The Role of Serotonin in Modulation of Nociceptive Reflexes
Harvey, J. A., & Simansky, K. J. (1981) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3860-4_7 · Cited by 15 · see citing works
TREATMENT OF NARCOLEPSY WITH L-TYROSINE: DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
Elwes, R. D. C., Chesterman, L. P., Jenner, P. G., Crewes, H., Summers, B., Binnie, C. D., & Parkes, J. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91081-7 · Cited by 14 · see citing works
Degradation of endogenous opioids: its relevance in human pathology and therapy
Ehrenpreis, S., & Sicuteri, F. (1983) · Raven Press eBooks · Cited by 13 · see citing works
Tyrosine's vasoactive effect in the dog shock model depends on the animal's starting blood pressure
Conlay, L. A., Maher, T. J., Moses, P. L., & Wurtman, R. J. (1983) · Journal of Neural Transmission · doi:10.1007/bf01249125 · Cited by 13 · see citing works
Supplemental Dietary Tyrosine in Sepsis and Acute Hemorrhagic Shock
Simón, R. (1987) · Archives of Surgery · doi:10.1001/archsurg.1987.01400130084013 · Cited by 13 · see citing works
The effect of tryptophan on postoperative endodontic pain
Shpeen, S. E., Morse, D. R., & Furst, M. L. (1984) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(84)90342-6 · Cited by 13 · see citing works
Improved cholesterol-related knowledge and behavior and plasma cholesterol levels in adults during the 1980s
Frank, E. (1992) · JAMA · doi:10.1001/jama.268.12.1566 · Cited by 13 · see citing works
Studies on phenylalanine metabolism by tracer techniques. IV. Biotransformation of D- and L-phenylalanine in man.
TOKUHISA, S., SAISU, K., NARUSE, K., Yoshikawa, H., & Baba, S. (1981) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.29.514 · Cited by 12 · see citing works
Choline enhances scopolamine-induced acetylcholine release in dorsal hippocampus of conscious, freely-moving rats
Jackson, D. A., Kischka, U., & Wurtman, R. J. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00406-i · Cited by 12 · see citing works
d-Phenylalanine: a putative enkephalinase inhibitor studied in a primate acute pain model
Halpern, L. M., & Dong, W. K. (1986) · Pain · doi:10.1016/0304-3959(86)90045-x · Cited by 12 · see citing works
Different influences of two types of diets commonly used for rats on a series of parameters related to the metabolism of central serotonin and noradrenaline
Héroux, O., & Roberge, A. G. (1981) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y81-019 · Cited by 12 · see citing works
l-Tryptophan supplementation does not affect postoperative pain intensity or consumption of analgesics
Ekblom, A., Hansson, P. T., & Thomsson, M. (1991) · Pain · doi:10.1016/0304-3959(91)90093-d · Cited by 11 · see citing works
L-tryptophan does not increase weight loss in carbohydrate-craving obese subjects.
Strain, G. W., Strain, J. J., & Zumoff, B. (1985) · PubMed · Cited by 10 · see citing works
Histidine-induced bizarre behaviour in rats: The possible involvement of central cholinergic system
Pilc, A., Rogóż, Z., & Skuza, G. (1982) · Neuropharmacology · doi:10.1016/0028-3908(82)90065-x · Cited by 10 · see citing works
Postoperative pain treated by intravenous l-tryptophan: a double-blind study versus placebo in cholecystectomized patients
Ceccherelli, F., Diani, M. M., Altafini, L., Varotto, E., Stefecius, A., Casale, R., Costola, A., & Giron, G. (1991) · Pain · doi:10.1016/0304-3959(91)90201-8 · Cited by 8 · see citing works
Dietary fat composition and age affect synaptosomal and retinal phospholipid fatty acid composition in C57BL/6 mice
McGee, C. D., Greenwood, C. E., & Cinader, B. (1994) · Lipids · doi:10.1007/bf02536094 · Cited by 8 · see citing works
NEUROTRANSMITTER PRECURSORS: FROM ANIMAL EXPERIMENTS TO HUMAN APPLICATIONS
Leathwood, P. D. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1986.tb07697.x · Cited by 8 · see citing works
An Experimental Study on the Enhancing Effects of Phenylalanine on Acupuncture Analgesia
Kitade, T., Minamikawa, M., Nawata, T., SHINOHARA, S., Hyodo, M., & Hosoya, E. (1981) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x81000329 · Cited by 7 · see citing works
Nutrition and the Brain, vol. 7 Food Constituents Affecting Normal and Abnormal Behaviors
Castonguay, T. W. (1988) · Journal of Nutrition · doi:10.1093/jn/118.9.1165 · Cited by 7 · see citing works
Effects of dietary histidine and methionine loading in rats with a portacaval shunt
Imura, K., Kamata, S., Hata, S., Okada, A., Watanabe, T., & Wada, H. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90191-7 · Cited by 6 · see citing works
Lack of evidence for the involvement of catecholaminergic mechanisms in the behavioral anti-methamphetamine effect of L-histidine in the mouse
Itoh, Y., Oishi, R., Nishibori, M., Saeki, K., Furuno, K., Fukuda, T., & Araki, Y. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90560-5 · Cited by 5 · see citing works
FDA's Electronic Bulletin Board
Nightingale, S. L. (1992) · JAMA · doi:10.1001/jama.1992.03490140032012 · Cited by 5 · see citing works
Effects of diet-induced hyperthreoninemia. II) Tissue and extracellular amino acid levels in the brain
Castagné, V., Finot, P. A., & Maire, J.-C. E. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00576-1 · Cited by 5 · see citing works
Effect of L-Tryptophan and Phenylalanine on Burning Pain Threshold
Mitchell, M. J., Daines, G. E., & Thomas, B. L. (1987) · Physical Therapy · doi:10.1093/ptj/67.2.203 · Cited by 5 · see citing works
The return of L‐tryptophan: Introduction
LADER, M. H. (1994) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.470090507 · Cited by 4 · see citing works
Metabolism of an amino acid with antidepressant properties.
Borison, R. L., Maple, P. J., Havdala, H. S., & Diamond, B. I. (1978) · PubMed · Cited by 4 · see citing works
From the Food and Drug Administration
Nightingale, S. L. (1992) · JAMA · doi:10.1001/jama.268.14.1828 · Cited by 4 · see citing works
D phenyl alanine in human chronic pain
Balagot, R. C., Ehrenpreis, S., Greenberg, J., & Hyodo, M. (1983) · Cited by 3 · see citing works
Eosinophilia myalgia syndrome
Deighton, C. (1990) · BMJ · doi:10.1136/bmj.301.6752.611-c · Cited by 2 · see citing works

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Proton NMR chemical shifts and coupling constants for brain metabolites
Govindaraju, V., Young, K., & Maudsley, A. A. (2000) · NMR in Biomedicine · doi:10.1002/1099-1492(200005)13:3 · Cited by 1,695 · see citing works
Role of Serotonin in the Paradoxical Calming Effect of Psychostimulants on Hyperactivity
Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Levin, E. D., Jaber, M., & Caron, M. G. (1999) · Science · doi:10.1126/science.283.5400.397 · Cited by 885 · see citing works
L -Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications
Richard, D. M., Dawes, M. A., Mathias, C. W., Acheson, A., Hill‐Kapturczak, N., & Dougherty, D. M. (2009) · International Journal of Tryptophan Research · doi:10.4137/ijtr.s2129 · Cited by 705 · see citing works
Forebrain activation in REM sleep: an FDG PET study
Nofzinger, E. A., Mintun, M. A., Wiseman, M., Kupfer, D. J., & Moore, R. Y. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00807-x · Cited by 501 · see citing works
Effects of tryptophan loading on human cognition, mood, and sleep
Silber, B. Y., & Schmitt, J. A. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.005 · Cited by 260 · see citing works
Serotonin and Human Cognitive Performance
Schmitt, J. A. J., Wingen, M., Ramaekers, J. G., Evers, E. A. T., & Riedel, W. J. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777698909 · Cited by 258 · see citing works
Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers
Schmitt, J. A. J., Jorissen, B. L., Sobczak, S., van Boxtel, M. P. J., Hogervorst, E., Deutz, N. E. P., & Riedel, W. J. (2000) · Journal of Psychopharmacology · doi:10.1177/026988110001400102 · Cited by 227 · see citing works
Peanuts and Their Nutritional Aspects—A Review
Settaluri, V. S., Kandala, C. V. K., Puppala, N., & Sundaram, J. (2012) · Food and Nutrition Sciences · doi:10.4236/fns.2012.312215 · Cited by 201 · see citing works
An Update on the Role of Serotonin and its Interplay with Dopamine for Reward
Fischer, A. G., & Ullsperger, M. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00484 · Cited by 176 · see citing works
Nutritional and medicinal aspects of d-amino acids
Friedman, M., & Levin, C. E. (2011) · Amino Acids · doi:10.1007/s00726-011-0915-1 · Cited by 168 · see citing works
Effect of exogenous tryptophan on cannibalism, survival and growth in juvenile grouper, Epinephelus coioides
Hseu, J.-R., Lu, F., Su, H. M., Wang, L. S., Tsai, C. L., & Hwang, P. (2003) · Aquaculture · doi:10.1016/s0044-8486(02)00503-3 · Cited by 129 · see citing works
Cognitive methods for assessing mental energy
Lieberman, H. R. (2007) · Nutritional Neuroscience · doi:10.1080/10284150701722273 · Cited by 118 · see citing works
Alpha-lactalbumin-enriched diets enhance serotonin release and induce anxiolytic and rewarding effects in the rat
Orosco, M., Rouch, C., Beslot, F., Feurte, S., Regnault, A., & Daugé, V. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00153-0 · Cited by 103 · see citing works
Acute tryptophan depletion induced by a gelatin-based mixture impairs object memory but not affective behavior and spatial learning in the rat
Lieben, C. K. J., van Oorsouw, K. I. M., Deutz, N. E. P., & Blokland, A. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.08.002 · Cited by 93 · see citing works
Behavioral and cognitive effects of tyrosine intake in healthy human adults
Hase, A., Jung, S. E., & aan het Rot, M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.008 · Cited by 91 · see citing works
Protein restriction cycles reduce IGF ‐1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model
Parrella, E., Maxim, T., Maialetti, F., Zhang, L., Wan, J., Wei, M., Cohen, P., Fontana, L., & Longo, V. D. (2013) · Aging Cell · doi:10.1111/acel.12049 · Cited by 87 · see citing works
Developmental Programming and Reprogramming of Hypertension and Kidney Disease: Impact of Tryptophan Metabolism
Hsu, C., & Tain, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228705 · Cited by 86 · see citing works
Acute tryptophan and serotonin depletion using an optimized tryptophan-free protein–carbohydrate mixture in the adult rat
Lieben, C. K. J. (2003) · Neurochemistry International · doi:10.1016/s0197-0186(03)00102-5 · Cited by 82 · see citing works
Impact of nutrition on canine behaviour: current status and possible mechanisms
Bosch, G., Beerda, B., Hendriks, W. H., van der Poel, A. F. B., & Verstegen, M. W. A. (2007) · Nutrition Research Reviews · doi:10.1017/s095442240781331x · Cited by 70 · see citing works
Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer’s models
Rangan, P., Lobo, F., Parrella, E., Rochette, N. C., Morselli, M., Stephen, T., Cremonini, A. L., Tagliafico, L., Persia, A., Caffa, I., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111417 · Cited by 68 · see citing works
Use of neurotransmitter precursors for treatment of depression.
Meyers, S. (2000) · PubMed · Cited by 69 · see citing works
Supplementing Healthy Women with up to 5.0 g/d of L-Tryptophan Has No Adverse Effects
Hiratsuka, C., Fukuwatari, T., Sano, M., Saito, K., Sasaki, S., & Shibata, K. (2013) · Journal of Nutrition · doi:10.3945/jn.112.173823 · Cited by 64 · see citing works
The effects of a diet enriched with α-lactalbumin on mood and cortisol response in unmedicated recovered depressed subjects and controls
Merens, W., Booij, L., Markus, R., Zitman, F. G., Onkenhout, W., & van der Does, W. A. J. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051492 · Cited by 59 · see citing works
Memory function in women with premenstrual complaints and the effect of serotonergic stimulation by acute administration of an alpha-lactalbumin protein
Schmitt, J. A. J., Jorissen, B. L., Dye, L., Markus, C. R., Deutz, N. E. P., & Riedel, W. J. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105053288 · Cited by 43 · see citing works
Flow-injection chemiluminescence determination of tryptophan through its peroxidation and epoxidation by peroxynitrous acid
Liang, Y., & Song, J. (2005) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2004.12.010 · Cited by 42 · see citing works
Improving therapeutics in anorexia nervosa with tryptophan
Haleem, D. (2017) · Life Science · doi:10.1016/j.lfs.2017.04.015 · Cited by 38 · see citing works
Treatment of multiple sclerosis with lofepramine, l-phenylalanine and vitamin B12: mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems
Loder, C., Allawi, J., & Horrobin, D. F. (2002) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00261-x · Cited by 40 · see citing works
Influence of sex and estrous cycle on the effects of acute tryptophan depletion induced by a gelatin-based mixture in adult Wistar rats
Jans, L. A. W., Lieben, C. K. J., & Blokland, A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.028 · Cited by 38 · see citing works
Tyrosine improves behavioral and neurochemical deficits caused by cold exposure
Yeghiayan, S. K., Luo, S., Shukitt‐Hale, B., & Lieberman, H. R. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00398-x · Cited by 37 · see citing works
Enriching the Content of Proteins and Essential Amino Acids in Legumes
Ahmed, H. G. M., Naeem, M., Faisal, A., Fatima, N., Tariq, S., & Owais, M. (2023) · Springer eBooks · doi:10.1007/978-3-031-33957-8_18 · Cited by 30 · see citing works
Effects of a carbohydrate-enriched night meal on sleepiness and sleep duration in night workers: A double-blind intervention
Nehme, P., Marqueze, E. C., Ulhôa, M. A., Moulatlet, E. M., Codarin, M. A. F., & Moreno, C. R. D. C. (2014) · Chronobiology International · doi:10.3109/07420528.2013.821478 · Cited by 26 · see citing works
Anti-Stress and Anti-Depressive Effects of Spinach Extracts on a Chronic Stress-Induced Depression Mouse Model through Lowering Blood Corticosterone and Increasing Brain Glutamate and Glutamine Levels
Son, H., Jung, S., Shin, J. H., Kang, M., & Kim, H. J. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7110406 · Cited by 27 · see citing works
Improved method for the measurement of large neutral amino acids in biological matrices
Bongiovanni, R., Yamamoto, B. K., & Jaskiw, G. E. (2001) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)00629-0 · Cited by 26 · see citing works
Aspectos psicobiológicos do comportamento alimentar
Cambraia, R. P. (2004) · Revista de Nutrição · doi:10.1590/s1415-52732004000200008 · Cited by 25 · see citing works
Insights into the Effects of Crack Abuse on the Human Metabolome Using a NMR Approach
Costa, T. B. B. C., Lacerda, A. L. T., Mas, C. D., Brietzke, E. M., Pontes, J. G. D. M., Marins, L. A. N., Martins, L. G., Nunes, M. V., Pedrini, M., Carvalho, M. S., et al. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00646 · Cited by 24 · see citing works
Tryptophan overloading activates brain regions involved with cognition, mood and anxiety
SILVA, L. C. A., Viana, M. D. B., ANDRADE, J. S., Souza, M. A., Céspedes, I. C., & D’Almeida, V. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160177 · Cited by 21 · see citing works
Effects of L‐histidine depletion and L‐tyrosine/L‐phenylalanine depletion on sensory and motor processes in healthy volunteers
van Ruitenbeek, P., Sambeth, A., Vermeeren, A., Young, S. N., & Riedel, W. J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00203.x · Cited by 20 · see citing works
Self-citation
The Antidepressant Effect of L-Tyrosine-Loaded Nanoparticles: Behavioral Aspects
Al‐Absi, A., Khoudary, A. C., & Abdelwahed, W. (2016) · Annals of Neurosciences · doi:10.1159/000443575 · Cited by 21 · see citing works
Criblage pharmacologique primaire d’une plante endémique originaire du Sud Marocain (Tetraena gaetula [Emb. & Maire] Beier & Thulin)
Youbi, A. E. H. E., Bousta, D., Ouahidi, I., & Aarab, L. (2010) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2010.08.001 · Cited by 19 · see citing works
One-Stage Chiral Enrichment Process by Continuous Flow Electrodialysis with Molecularly Imprinted Membrane
Fadillah, G., Toda, K., & Ohira, S.-I. (2022) · Separation and Purification Technology · doi:10.1016/j.seppur.2022.122492 · Cited by 18 · see citing works
Improving Mental Health for the Mother-Infant Dyad by Nutrition and the Maternal Gut Microbiome
Bernabé, B. P., Tussing-Humphreys, L. M., Rackers, H., Welke, L., Mantha, A., & Kimmel, M. (2019) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2019.04.007 · Cited by 17 · see citing works
1H-NMR Chemical Shifts and Coupling Constants for Brain Metabolites
Govind, V. (2016) · Encyclopedia of Magnetic Resonance · doi:10.1002/9780470034590.emrstm1530 · Cited by 17 · see citing works
Traumatic brain injury, abnormal growth hormone secretion, and gut dysbiosis
Armstrong, P. A., Venugopal, N. K., Wright, T. J., Randolph, K. M., Batson, R. D., Yuen, K. C. J., Masel, B. E., Sheffield‐Moore, M., Urban, R. J., & Pyles, R. B. (2023) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2023.101841 · Cited by 14 · see citing works
Effect of fitness on glucose, insulin and cortisol responses to diets varying in starch and fat content in Thoroughbred horses with recurrent exertional rhabdomyolysis
Finno, C. J., McKenzie, E. C., Valberg, S. J., & Pagan, J. D. (2010) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.2010.00199.x · Cited by 14 · see citing works
Dietary supplementation of L-tryptophan: Effect on growth and survival of Pabda, Ompok bimaculatus (Bloch) fry
Biswas, P., Rawat, P., Patel, A. B., & Jena, A. K. (2018) · Journal of Applied Aquaculture · doi:10.1080/10454438.2018.1545721 · Cited by 14 · see citing works
Food ingredients and cognitive performance
le Coutre, J., & Schmitt, J. A. J. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831394a5 · Cited by 14 · see citing works
Differences in how macaques monitor others: Does serotonin play a central role?
Weinberg‐Wolf, H., & Chang, S. W. C. (2019) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1494 · Cited by 14 · see citing works
Macronutrients and water – do they matter in the context of cognitive performance in athletes?
Karpęcka-Gałka, E., & Frączek, B. (2020) · Baltic Journal of Health and Physical Activity · doi:10.29359/bjhpa.12.3.11 · Cited by 13 · see citing works
Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomics Reveals Metabolic Alterations in the Mouse Cerebellum During Toxoplasma gondii Infection
Ma, J., He, J.-J., Hou, J.-L., Zhou, C., Elsheikha, H. M., & Zhu, X. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01555 · Cited by 13 · see citing works
Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study
Rappaport, L. M., Russell, J. J., Hedeker, D., Pinard, G., Bleau, P., & Moskowitz, D. S. (2018) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170141 · Cited by 12 · see citing works
Beneficial Effects of a Protein Free, High Carbohydrate Meal on Rat Coping Behavior and Neurotransmitter Levels During Heat Stress
Yeghiayan, S. K., Georgelis, J. H., Maher, T. J., & Lieberman, H. R. (2004) · Nutritional Neuroscience · doi:10.1080/10284150400017330 · Cited by 11 · see citing works
Determination of phenylalanine enantiomers in the plasma and urine of mammals and ᴅ-amino acid oxidase deficient rodents using two-dimensional high-performance liquid chromatography
Hsiao, S.-W., Ishii, C., Furusho, A., Hsieh, C.-L., Shimizu, Y., Akita, T., Mita, M., Okamura, T., Konno, R., Ide, T., et al. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140540 · Cited by 11 · see citing works
The potential of 5-hydryoxytryptophan for hot flash reduction: a hypothesis.
Curcio, J. J., Kim, L. S., Wollner, D. A., & Pockaj, B. A. (2005) · PubMed · Cited by 11 · see citing works
Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats
Saeed, R., Mahmood, K., Ali, S. B., & Haleem, D. J. (2022) · International Journal of Tryptophan Research · doi:10.1177/11786469221104729 · Cited by 10 · see citing works
No effect of oral tyrosine on total tyrosine levels in breast milk: implications for dietary supplementation in early postpartum
Dowlati, Y., Ravindran, A. V., Maheux, M., Steiner, M. S., Stewart, D. E., & Meyer, J. H. (2014) · Archives of Women s Mental Health · doi:10.1007/s00737-014-0441-8 · Cited by 10 · see citing works
Metal Ion‐Assisted Infrared Optical Sensor for Selective Determination of Tryptophan in Urine Samples
Huang, G. G., Cheng, M., & Yang, J. (2011) · Journal of the Chinese Chemical Society · doi:10.1002/jccs.201190003 · Cited by 10 · see citing works
Aurantiochytrium dietary supplements reduce intra-cohort cannibalism among orange-spotted groupers (Epinephelus coioides) by modulating brain 5-HT and serum cortisol
Chang, Y.-H., Lin, Y., Hsieh, C., & Chen, Y.-M. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.12.042 · Cited by 10 · see citing works
A low-protein diet alters rat behavior and neurotransmission in normothermic and hyperthermic environments
Lieberman, H. R., Yeghiayan, S. K., & Maher, T. J. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.04.011 · Cited by 9 · see citing works
Bioactive peptide effect on brain activity identified by 2D brain mapping
Turnip, A., Kusumandari, D. E., Simbolon, A. I., & Duhita, N. (2020) · Open Agriculture · doi:10.1515/opag-2020-0085 · Cited by 9 · see citing works
Optimum operational conditions for chiral separation of tryptophan enatiomers using ligand exchange liquid chromatography
Yan, H., & Row, K. H. (2007) · Biotechnology and Bioprocess Engineering · doi:10.1007/bf02931098 · Cited by 9 · see citing works
Conversion of L-Tryptophan into Melatonin Is the Possible Action Pathway Involved in the Effect of L-Tryptophan on Antidepressant-Related Behavior in Female Rats: Analysis of the Influence of Treatment Duration
Ouakki, S., Mrabet, F. Z. E., Hessni, A. E., Mesfioui, A., Pévet, P., & Ouichou, A. (2013) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2013.34036 · Cited by 8 · see citing works
Serotonergic Dysfunction in Mood Disorders
Mann, J. J., & Currier, D. (2007) · doi:10.1201/9780824741891-12 · Cited by 8 · see citing works
L-Tryptophan Mitigates Cannibalism and Improves Growth of Asian seabass, Lates calcarifer Reared in a RAS System
Khan, M. S. K., Salin, K. R., Yakupitiyage, A., Tsusaka, T. W., Nguyen, L. T., & Siddique, M. A. M. (2023) · Aquaculture Journal · doi:10.3390/aquacj3030014 · Cited by 7 · see citing works
Stress-Induced Hyperthermia, the Serotonin System and Anxiety
Vinkers, C., Olivier, B., Bouwknecht, J., Groenink, L., & Olivier, J. (2010) · Radboud Repository (Radboud University) · doi:10.2174/1874143601004010015 · Cited by 8 · see citing works
Development of high-protein biscuits by the enrichment with mopane worm ( Gonimbrasia belina ) flour
Mashau, M. E., Ramalisa, T., Ramashia, S. E., & Mshayisa, V. V. (2024) · Food Science and Technology International · doi:10.1177/10820132241283322 · Cited by 6 · see citing works
The contribution of prenatal stress to the pathogenesis of autism as a neurobiological developmental disorder: a dizygotic twin study
Claassen, M., Naudé, H., Pretorius, E., & Bosman, M. C. (2008) · Early Child Development and Care · doi:10.1080/03004430600851173 · Cited by 5 · see citing works
Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates
Weinberg-Wolf, H., Fagan, N. A., Monte, O. D., & Chang, S. W. C. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0413-21.2021 · Cited by 4 · see citing works
The Genetic Determinants of Ingestive Behavior
Eny, K. M., & El‐Sohemy, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374387-9.00012-x · Cited by 3 · see citing works
Emotional and interpersonal mechanisms in community SSRI treatment of social anxiety disorder
Rappaport, L. M., Hunter, M. D., Russell, J. J., Pinard, G., Bleau, P., & Moskowitz, D. S. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190164 · Cited by 2 · see citing works
Amino Acids, Brain Metabolism, Mood, and Behavior
Young, S. N. (2005) · Nutrition, brain, and behavior./Nutrition, brain and behavior · doi:10.1201/9780203564554.ch9 · Cited by 2 · see citing works
Self-citation
The Antioxidant and Antidepressant Properties of Dietary Proteins Derived from Egg and Bean Extracts and Their Acute Toxicity: A Journey from Nutrition to Pharmacognosy
Amal, E. H. E. Y., Boudaia, O., Sekkout, Z., Najat, E. A., & Radallah, D. (2023) · IgMin Research · doi:10.61927/igmin114 · Cited by 1 · see citing works
Einfluss der Ernährung auf Depressivität und Stresstoleranz
Schek, A. (2003) · Forum Psychotherapeutische Praxis · doi:10.1026//1616-1041.3.4.163 · Cited by 1 · see citing works
Antidepressants, serotonin and cognition : applied and fundamental studies in human volunteers
Wingen, M. (2007) · doi:10.26481/dis.20070524mw · Cited by 1 · see citing works
Serotonergic Dysfunction in Mood Disorders
JohnMann, J., & Currier, D. (2007) · Medical psychiatry · doi:10.3109/9781420021158.005 · Cited by 1 · see citing works
The expression of personality among adolescents exposed to interpersonal violence
Claassen, M. (2015) · UpSpace Institutional Repository (University of Pretoria)
Manipulating serotonin function in depression
Merens, W. (2003) · Leiden Repository (Leiden University)
Serotonergic vulnerability : experimental studies in rats applying the method of acute tryptophan depletion
Jans, L. A. W. (2008) · doi:10.26481/dis.20080530lj
Histaminergic manipulations of human cognition: studies of pharmacological effects on evoked potentials and performance tests
van Ruitenbeek, P. (2009) · doi:10.26481/dis.20090508pr
Suplementação de triptofano na atividade elétrica cerebral (EEG) e glicemia de cães da raça Pit Bull
Elmôr, L. D. (2009) · doi:10.11606/d.74.2009.tde-13042009-091204
Validity of Urinary Neurotransmitter Testing with Clinical Applications of the CSM™ (Communication System Management) Model
Watkins, R. (2009)
Tryptophan Supplementation in the Pharmacotherapy of Anorexia Nervosa
Haleem, D. J. (2016) · Journal of Nutritional Health & Food Engineering · doi:10.15406/jnhfe.2016.04.00140
The use of Nutraceuticals as Mono- or Adjuvant Therapy to Pharmacotherapies in Major Depressive Disorder
van Houtum, L. A. E. M., & Deijen, J. B. (2016) · International Neuropsychiatric Disease Journal · doi:10.9734/indj/2016/29568
Chemiluminescence Determination of L-Tryptophan in Compound Amino Acid Injection Based on Capillary Electrophoresis Analysis
Wu, Y., & Han, S. (2016) · Analytical chemistry, an Indian journal
Aminpräkursoren
Bandelow, B., Rüther, E., Bruinvels, J., Riederer, P. F., & Kasper, S. F. (2002) · Springer eBooks · doi:10.1007/978-3-7091-6150-0_10
Single silver ions facilitate intramolecular hydrogen atom transfer and C–C bond dissociation of neurotransmitters
Yi, Q., Wu, H., & Luo, Z. (2023) · Chinese Journal of Chemical Physics · doi:10.1063/1674-0068/cjcp2309091
Plasma amino acid fluctuations in response to acute psychosocial stress among healthy adults with and without early-life adversity
Ye, Q., Etzel, L. C., Apsley, A. T., Ahamed, A., Chiaro, C. R., Davis, A., Hastings, W. J., Kozlosky, J. T., Petri, L., & Shalev, I. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107976

Authors: Young, S. N.
Affiliations: McGill University (CA)
Corresponding author: Young, Simon N.
ORCID: Young, Simon N.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 1996-01
Volume: 20
Issue: 2
Pages: 313-323
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/0149-7634(95)00022-4
OpenAlex: W2009278722
Cited by: 86
References: 150
Citations by year: 2026: 1 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
FWCI: 0.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords: tryptophan, tyrosine, histidine, choline, threonine, serotonin, dopamine, norepinephrine, histamine, acetylcholine, glycine, depression treatment, behavioral effects, amino acid supplementation
MeSH terms: Animals, Behavior, Behavior, Animal, Mental Disorders, Diet, Humans, Neurotransmitter Agents

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