The DOI matches its Crossref record.
Solvent-Accessible Surfaces of Proteins and Nucleic Acids
Abstract
A method is presented for analytically calculating a smooth, three-dimensional contour about a molecule. The molecular surface envelope may be drawn on either color raster computer displays or real-time vector computer graphics systems. Molecular areas and volumes may be computed analytically from this surface representation. Unlike most previous computer graphics representations of molecules, which imitate wire models or space-filling plastic spheres, this surface shows only the atoms that are accessible to solvent. This analytical method extends the earlier dot surface numerical algorithm, which has been applied in enzymology, rational drug design, immunology, and understanding DNA base sequence recognition.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Kühne, T. D., Iannuzzi, M., Del Ben, M., Rybkin, V. V., Seewald, P., Stein, F., Laino, T., Khaliullin, R. Z., Schütt, O., Schiffmann, F., et al. (2020) · The Journal of Chemical Physics · doi:10.1063/5.0007045 · Cited by 4,468
PatchDock and SymmDock: servers for rigid and symmetric docking
Schneidman-Duhovny, D., Inbar, Y., Nussinov, R., & Wolfson, H. J. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki481 · Cited by 3,018
Solving the multiple instance problem with axis-parallel rectangles
Dietterich, T. G., Lathrop, R. H., & Lozano-Pérez, T. (1997) · Artificial Intelligence · doi:10.1016/s0004-3702(96)00034-3 · Cited by 2,866
CASTp 3.0: computed atlas of surface topography of proteins
Tian, W., Chen, C., Lei, X., Zhao, J., & Liang, J. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky473 · Cited by 2,389
Benchmarking sets for molecular docking.
Huang, N., Shoichet, B. K., & Irwin, J. J. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0608356 · Cited by 1,318
Principles of docking: An overview of search algorithms and a guide to scoring functions
Halperin, I., Ma, B., Wolfson, H., & Nussinov, R. (2002) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.10115 · Cited by 1,294
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
Uversky, V. N., Oldfield, C. J., & Dunker, A. K. (2005) · Journal of Molecular Recognition · doi:10.1002/jmr.747 · Cited by 847
Bledsoe, R. K., Montana, V. G., Stanley, T. B., Delves, C. J., Apolito, C. J., McKee, D. D., Consler, T. G., Parks, D. J., Stewart, E. L., Willson, T. M., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00817-6 · Cited by 818
Electrostatic recognition between superoxide and copper, zinc superoxide dismutase
Getzoff, E. D., Tainer, J. A., Weiner, P. K., Kollman, P. A., Richardson, J. S., & Richardson, D. C. (1983) · Nature · doi:10.1038/306287a0 · Cited by 554
Collawn, J. F., Stangel, M., Kuhn, L. A., Esekogwu, V., Jing, S., Trowbridge, I. S., & Tainer, J. A. (1990) · Cell · doi:10.1016/0092-8674(90)90509-d · Cited by 518
Sulfite Reductase Structure at 1.6 Å: Evolution and Catalysis for Reduction of Inorganic Anions
Crane, B. R., Siegel, L. M., & Getzoff, E. D. (1995) · Science · doi:10.1126/science.270.5233.59 · Cited by 345
Three-dimensional structure of poliovirus serotype 1 neutralizing determinants
Page, G. S., Mosser, A. G., Hogle, J. M., Filman, D. J., Rueckert, R. R., & Chow, M. (1988) · Journal of Virology · doi:10.1128/jvi.62.5.1781-1794.1988 · Cited by 222
Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation
Sayed, N., Baskaran, P., Ma, X., van den Akker, F., & Beuve, A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703944104 · Cited by 221
Louie, G. V., Brownlie, P. D., Lambert, R., Cooper, J. B., Blundell, T. L., Wood, S. P., Warren, M. J., Woodcock, S. C., & Jordan, P. M. (1992) · Nature · doi:10.1038/359033a0 · Cited by 199
CASTpFold: Computed Atlas of Surface Topography of the universe of protein Folds
Ye, B., Tian, W., Wang, B., & Liang, J. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae415 · Cited by 180
N‐terminal domain swapping and metal ion binding in nitric oxide synthase dimerization
Crane, B. R., Rosenfeld, R. J., Arvai, A. S., Ghosh, D. K., Ghosh, S., Tainer, J. A., Stuehr, D. J., & Getzoff, E. D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.22.6271 · Cited by 110
Integrative structure modeling of macromolecular assemblies from proteomics data
Lasker, K., Phillips, J. L., Russel, D., Velázquez-Muriel, J., Schneidman-Duhovny, D., Tjioe, E., Webb, B., Schlessinger, A., & Sali, A. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r110.000067 · Cited by 71
BetaCavityWeb: a webserver for molecular voids and channels
Kim, J.-K., Cho, Y., Lee, M., Laskowski, R. A., Ryu, S. E., Sugihara, K., & Kim, D.-S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv360 · Cited by 50
Homology modeling of tubulin: Influence predictions for microtubule’s biophysical properties
Carpenter, E. J., Huzil, J. T., Ludueña, R. F., & Tuszynski, J. A. (2006) · European Biophysics Journal · doi:10.1007/s00249-006-0088-0 · Cited by 23
Poso, D., Sessions, R. B., Lorch, M., & Clarke, A. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001747200 · Cited by 23
Murmu, S., Rashmi, M., Nagrale, D. T., Kour, T., Singh, M. K., Chaurasia, A., Behera, S. K., Shankar, R., Ranjan, R., Jha, G. K., et al. (2025) · Journal of Cotton Research · doi:10.1186/s42397-024-00203-z · Cited by 7
Metadata
- Authors
- Connolly, M. L.
- Venue
- Science
- Published
- 1983-08-19
- Volume
- 221
- Issue
- 4612
- Pages
- 709-713
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2108508060
- Cited by
- 2,745
- References
- 0
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
