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Cited by 5,545Cholinesterase and Neurodegenerative DiseasesDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

Bartus, Raymond T., Dean, Reginald L., Beer, Bernard, Lippa, Arnold S.·1982·Science
DOI 10.1126/science.7046051
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Abstract

Biochemical, electrophysiological, and pharmacological evidence supporting a role for cholinergic dysfunction in age-related memory disturbances is critically reviewed. An attempt has been made to identify pseudoissues, resolve certain controversies, and clarify misconceptions that have occurred in the literature. Significant cholinergic dysfunctions occur in the aged and demented central nervous system, relationships between these changes and loss of memory exist, similar memory deficits can be artificially induced by blocking cholinergic mechanisms in young subjects, and under certain tightly controlled conditions reliable memory improvements in aged subjects can be achieved after cholinergic stimulation. Conventional attempts to reduce memory impairments in clinical trials hav not been therapeutically successful, however. Possible explanations for these disappointments are given and directions for future laboratory and clinical studies are suggested.

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Crossref · 10.1126/science.7046051

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158 of 158 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 36

  1. BARBEAU, A, LECITHIN IN NEUROLOGIC DISORDERS, NEW ENGLAND JOURNAL OF MEDICINE 299: 200 (1978).
  2. BARTUS, R.T., AGING 10: 85 (1979).
  3. BONDAREFF, W, LANCET 1: 784 (1981).
  4. BOWEN, D.M., TREATMENT OF ALZHEIMERS-DISEASE - A CAUTIONARY NOTE, NEW ENGLAND JOURNAL OF MEDICINE 305: 1016 (1981).
  5. BOYD, W.D., CLINICAL EFFECTS OF CHOLINE IN ALZHEIMER SENILE DEMENTIA, LANCET 2: 711 (1977).
  6. CAIRD, W.K., J GERONTOL 21: 195 (1966).
  7. DAVIES, P, BRAIN RES 138: 385 (1978).
  8. DAVIS, K.L., LIFE SCI 22: 2699 (1978).
  9. DAVIS, K.L., CHOLINE FOR TARDIVE-DYSKINESIA, NEW ENGLAND JOURNAL OF MEDICINE 293: 152 (1975).
  10. DAVIS, K.L., ENHANCEMENT OF MEMORY BY PHYSOSTIGMINE, NEW ENGLAND JOURNAL OF MEDICINE 301: 946 (1979).
  11. ECKERNAS, S. A., ACTA PHYSIOLOGICA SCANDINAVICA 449: 1 (1977).
  12. ETIENNE, P, LANCET 1: 500 (1978).
  13. ETIENNE, P, LECITHIN IN ALZHEIMERS-DISEASE, LANCET 2: 1206 (1978).
  14. FERRIS, S. H., Combination Choline/Piracetam Treatment of Senile Dementia, PSYCHOPHARMACOLOGY BULLETIN 18: 94 (1982).
  15. FORNO, L. S., JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 37: 614 (1978).
  16. FROLKIS, V.V., INTERDISCIP TOP GERO 16: 1 (1979).
  17. GIBSON, G.E., NEUROTRANSMITTER AND CARBOHYDRATE-METABOLISM DURING AGING AND MILD HYPOXIA, NEUROBIOLOGY OF AGING 2: 165 (1981). · DOI
  18. GLURGEA, C, CURR DEV PSYCHOPHARM 3: 221 (1976).
  19. HOLBERT, N.M., GERONTOLOGY 1: 131 (1976).
  20. JENSEN, R.A., AGING 1980S PSYCHOL: 191 (1980).
  21. KATZMAN, R, LANCET 2: 1403 (1976).
  22. KUHAR, J.J., BIOL CHOLINERGIC FUN: 3 (1976).
  23. KUTZ, P, BEHAV REV 1: 25 (1977).
  24. LIPPA, A.S., NEUROBIOL AGING 1: 10 (1980).
  25. MARRIOTT, J.G., SOCIETY FOR NEUROSCIENCE. ABSTRACTS 5: 319 (1979).
  26. MORIN, A.M., NEUROCHEM RES 5: 310 (1980).
  27. PALACIOS, J.M., MOL PHARM 16: 1984 (1979).
  28. PERRY, E.K., NORADRENERGIC AND CHOLINERGIC SYSTEMS IN SENILE DEMENTIA OF ALZHEIMER TYPE, LANCET 2: 149 (1981).
  29. RENVOISE, D.G., NEW ENGLAND JOURNAL OF MEDICINE 301: 330 (1979).
  30. SCHMIDT, D.E., NEUROSCIENCE ABSTRACTS 4: 433 (1978).
  31. SIGNORET, J.L., INFLUENCE OF CHOLINE ON AMNESIA IN EARLY ALZHEIMERS-DISEASE, LANCET 2: 837 (1978).
  32. SMITH, C.M., CHOLINE THERAPY IN ALZHEIMERS-DISEASE, LANCET 2: 318 (1978).
  33. SMITH, C.M., LANCET 1: 42 (1979).
  34. VROULIS, G.A., PSYCHOPHARMACOLOGY BULLETIN 17: 127 (1981).
  35. WHITELEY, A, REV NEUROL 135: 565 (1973).
  36. YATES, C.M., DOPAMINE IN ALZHEIMERS-DISEASE AND SENILE DEMENTIA, LANCET 2: 851 (1979).

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Metadata

Authors
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S.
Affiliations
  • NYU Langone Health (US)
  • Department of CNS Research, Lederle Laboratories of American Cyanamid Co., Pearl River, New York 10965.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1982-07-30
Volume
217
Issue
4558
Pages
408-414
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7046051
OpenAlex
W1994067502
Cited by
5,545
References
158
Citations by year
2026: 66 · 2025: 98 · 2024: 90 · 2023: 107 · 2022: 130 · 2021: 142 · 2020: 123 · 2019: 119 · 2018: 130 · 2017: 116 · 2016: 122 · 2015: 111 · 2014: 139 · 2013: 145 · 2012: 132
FWCI
11.90
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cholinergic hypothesis, age-related memory impairment, cholinergic dysfunction, dementia, cholinergic stimulation, cholinergic blockade
MeSH terms
Acetylcholine, Adult, Aged, Aging, Alzheimer Disease, Animals, Brain Chemistry, Choline, Choline O-Acetyltransferase, Cognition, Forecasting, Humans, Memory, Memory Disorders, Models, Neurological, Parasympathetic Nervous System, Parasympathomimetics, Phosphatidylcholines, Receptors, Muscarinic, Mice, Rats

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