The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons
Abstract
Voltage clamp recordings and noise analysis from pyramidal cells in hippocampal slices indicate that N -methyl-D-aspartate (NMDA) receptors are tonically active. On the basis of the known concentration of glutamate in the extracellular fluid, this tonic action is likely caused by the ambient glutamate level. NMDA receptors are voltage-sensitive, thus background activation of these receptors imparts a regenerative electrical property to pyramidal cells, which facilitates the coupling between dendritic excitatory synaptic input and somatic action potential discharge in these neurons.
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Citations
Cites
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Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L., Bregestovski, P., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,043
Glycine potentiates the NMDA response in cultured mouse brain neurons
Johnson, J. W., & Ascher, P. (1987) · Nature · doi:10.1038/325529a0 · Cited by 3,139
Excitatory Amino Acid Transmitters
Watkins, J. C., & Evans, R. H. (1981) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001121 · Cited by 2,491
Llinás, R. R. (1988) · Science · doi:10.1126/science.3059497 · Cited by 2,285
Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain
Simon, R. P., Swan, J. H., Griffiths, T., & Meldrum, B. S. (1984) · Science · doi:10.1126/science.6093256 · Cited by 1,682
The Role of Excitatory Amino Acids and NMDA Receptors in Traumatic Brain Injury
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Cited by
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831
Mammalian nicotinic acetylcholine receptors: from structure to function
Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724
McCormick, D. A. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90012-4 · Cited by 1,117
Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus
Mulkey, R. M., & Malenka, R. C. (1992) · Neuron · doi:10.1016/0896-6273(92)90248-c · Cited by 1,113
Metadata
- Authors
- Sah, P., Hestrin, S., & Nicoll, R. A.
- Venue
- Science
- Published
- 1989-11-10
- Volume
- 246
- Issue
- 4931
- Pages
- 815-818
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994664430
- Cited by
- 441
- References
- 44
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sah, P., Hestrin, S., & Nicoll, R. A. (1989). Tonic Activation of NMDA Receptors by Ambient Glutamate Enhances Excitability of Neurons. Science. https://doi.org/10.1126/science.2573153
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
