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Intraneuronal Aluminum Accumulation in Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia of Guam
Abstract
Scanning electron microscopy with energy-dispersive x-ray spectrometry was used to analyze the elemental content of neurofibrillary tangle (NFT)-bearing and NFT-free neurons within the Sommer's sector (H 1 region) of the hippocampus in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia and in neurologically normal controls. Preliminary data indicate prominent accumulation of aluminum within the nuclear region and perikaryal cytoplasm of NFT-bearing hippocampal neurons, regardless of the underlying neurological diagnosis. These findings further extend the association between intraneuronal aluminum and NFT formation and support the hypothesis that environmental factors are related to the neurodegenerative changes seen in the Chamorro population.
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Cited by
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
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Metadata
- Authors
- Perl, D. P., Gajdusek, D. C., Garruto, R. M., Yanagihara, R. T., & Gibbs, C. J.
- Venue
- Science
- Published
- 1982-09-10
- Volume
- 217
- Issue
- 4564
- Pages
- 1053-1055
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2088327372
- Cited by
- 683
- References
- 0
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Perl, D. P., Gajdusek, D. C., Garruto, R. M., Yanagihara, R. T., & Gibbs, C. J. (1982). Intraneuronal Aluminum Accumulation in Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia of Guam. Science. https://doi.org/10.1126/science.7112111
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