The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Prolonged Ca 2+ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats
Abstract
The possibility that calcium is elevated in brain neurons during aging was examined by quantifying afterhyperpolarizations induced by spike bursts in CA1 neurons of hippocampal slices from young and aged rats. The afterhyperpolarizations result from Ca 2+ -dependent K + conductance increases and are blocked in medium low in Ca 2+ and prolonged in medium high in Ca 2+ . The afterhyperpolarization and associated conductance increases were considerably prolonged in cells from aged rats, although inhibitory postsynaptic potentials did not differ with age. Since elevated intracellular Ca 2+ can exert deleterious effects on neurons, the data suggest that altered Ca 2+ homeostasis may play a significant role in normal brain aging.
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Cites
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Cited by
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Gene regulation and DNA damage in the ageing human brain
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Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion
Sapolsky, R. M. (1996) · Stress · doi:10.3109/10253899609001092 · Cited by 738
The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death
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Metadata
- Authors
- Landfield, P. W., & Pitler, T. A.
- Venue
- Science
- Published
- 1984-11-30
- Volume
- 226
- Issue
- 4678
- Pages
- 1089-1092
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999304520
- Cited by
- 494
- References
- 36
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Landfield, P. W., & Pitler, T. A. (1984). Prolonged Ca 2+ -Dependent Afterhyperpolarizations in Hippocampal Neurons of Aged Rats. Science. https://doi.org/10.1126/science.6494926
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
