Corticosteroid Modulation of Hippocampal Potentials: Increased Effect with Aging
Abstract
Adrenal steroids bind specifically to hippocampal neurons under normal conditions and may contribute to hippocampal cell loss during aging, but little is known about the neurophysiological mechanisms by which they may change hippocampal cell function. In the present studies, adrenal steroids have been shown to modulate a well-defined membrane conductance in hippocampal pyramidal cells. The calcium-dependent slow afterhyperpolarization is reduced in hippocampal slices from adrenalectomized rats, and it is increased after in vivo or in vitro administration of the adrenal steroid, corticosterone. Calcium action potentials are also reduced in adrenalectomized animals, indicating that the primary effect of corticosteroids may be on calcium conductance. The afterhyperpolarization component reduced by adrenalectomy is greater in aged rats than in young rats, suggesting that, with aging, there is an increased effect of corticosteroids on some calcium-mediated brain processes. Because elevated concentrations of intracellular calcium can be cytotoxic, these observations may increase the understanding of glucocorticoid involvement in brain aging as well as of the normal functions of these steroids in the brain.
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Stress levels of corticosterone applied for a longer period of time (>20 minutes) increased the magnitude of inhibitory components of electrophysiological activity, such as the afterhyperpolarization, and suppressed the induction of LTP.
“Conversely, stress levels of corticosterone applied for a longer period of time (>20 minutes) increased the magnitude of inhibitory components of electrophysiological activity, such as the afterhyperpolarization (Joëls and de Kloet [233]; Kerr et al. [234]; Joëls and de Kloet [235]; Karst and Joëls [236]), and suppressed the induction of LTP (Pavlides et al. [237]; Rey et al. [238]; Kerr et al. [”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Kerr et al. [234]
Cites
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Hotson, J. R., & Prince, D. A. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.2.409 · Cited by 569 · see citing works
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Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works
Cortisol levels during human aging predict hippocampal atrophy and memory deficits
Lupien, S. J., de Leon, M., de Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., Thakur, M., McEwen, B. S., Hauger, R. L., & Meaney, M. J. (1998) · Nature Neuroscience · doi:10.1038/271 · Cited by 1,653 · see citing works
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543 · see citing works
Korte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097 · see citing works
Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020 · see citing works
Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
“[234]; Joëls and de Kloet [235]; Karst and Joëls [236]), and suppressed the induction of LTP (Pavlides et al.”
BackgroundGlucocorticoids and the regulation of memory consolidation
Roozendaal, B. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00058-x · Cited by 665 · see citing works
Basal cortisol levels and cognitive deficits in human aging
Lupien, S., Lecours, A., Lussier, I., Schwartz, G., Nair, N., & Meaney, M. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02893.1994 · Cited by 566 · see citing works
Kim, J. J., Lee, H. J., Han, J.-S., & Packard, M. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05222.2001 · Cited by 537 · see citing works
Chronic stress: Implications for neuronal morphology, function and neurogenesis
Joëls, M., Karst, H., Krugers, H. J., & Lucassen, P. J. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.04.001 · Cited by 381 · see citing works
Effects of glucocorticoids on hippocampal long‐term potentiation
Pavlides, C., Watanabe, Y., & McEwen, B. S. (1993) · Hippocampus · doi:10.1002/hipo.450030210 · Cited by 323 · see citing works
Lupien, S. J., Nair, N. P. V., Briére, S., Maheu, F., Tu, M. T., Lemay, Μ., McEwen, B. S., & Meaney, M. J. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.2.117 · Cited by 283 · see citing works
Opposing roles of type I and type II adrenal steroid receptors in hippocampal long-term potentiation
Pavlides, C., Watanabe, Y., Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00151-8 · Cited by 261 · see citing works
Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala
Johnson, L. R., Farb, C., Morrison, J. H., McEwen, B. S., & Ledoux, J. E. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.050 · Cited by 205 · see citing works
Kim, J. J., Koo, J. W., Lee, H. J., & Han, J.-S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4623-04.2005 · Cited by 184 · see citing works
Krugers (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00024 · Cited by 102 · see citing works
Molecular and cellular aspects of age-related cognitive decline and Alzheimer’s disease
Hullinger, R., & Puglielli, L. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.008 · Cited by 68 · see citing works
Vedder, H., Weiβ, I., Holsboer, F., & Reul, J. M. H. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91351-r · Cited by 46 · see citing works
Long-term adrenalectomy reduces hippocampal granule cell excitability in vivo
Margineanu, D.-G., Gower, A. J., Gobert, J., & Wülfert, E. (1994) · Brain Research Bulletin · doi:10.1016/0361-9230(94)90053-1 · Cited by 15 · see citing works
- Authors
- Kerr, D. S., Campbell, L. W., Hao, S.-Y., & Landfield, P. W.
- Affiliations
- Atrium Health Wake Forest Baptist (US)
- Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Winston-Salem, NC 27103.
- Venue
- Science
- Published
- 1989-09-29
- Volume
- 245
- Issue
- 4925
- Pages
- 1505-1509
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002264389
- Cited by
- 271
- References
- 1
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 6 · 2013: 10 · 2012: 3
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 04542)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- corticosteroids, glucocorticoids, hippocampus, brain aging, corticosterone, adrenalectomy, slow afterhyperpolarization, calcium conductance, hippocampal pyramidal neurons, calcium action potentials, hippocampal neuronal loss
- MeSH terms
- Action Potentials, Adrenal Cortex Hormones, Adrenalectomy, Aging, Animals, Calcium, Hippocampus, Male, Neurons, Rats, Inbred F344, Tetrodotoxin, Rats, In Vitro Techniques
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