The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Substantia Nigra: Site of Anticonvulsant Activity Mediated by γ-Aminobutyric Acid
Abstract
Localization of the anatomic substrate for anticonvulsant activity mediated by γ-aminobutyric acid (GABA) was examined using intracerebral injections of GABA agonists. Blockade of tonic hindlimb extension in the maximal electroshock test and blockade of tonic and clonic seizures produced by pentylenetetrazole and bicuculline were obtained by elevating GABA in the ventral midbrain tegmentum. Elevation of GABA in forebrain and hindbrain areas had no effect on convulsant activity. Blockade of tonic and clonic seizures was also obtained after microinjections of the direct GABA receptor agonist, muscimol, into the midbrain. The substantia nigra was identified as the critical midbrain site for GABA-mediated anticonvulsant activity. Local injection of GABA agonists into the midbrain provided seizure protection without a widespread augmentation of GABA-mediated activity throughout the brain and without impairing either alertness or motor function. Synapses in the substantia nigra appear to represent an important control mechanism for inhibiting the propagation of generalized convulsions.
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Cites
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Grace, A. A., & Bunney, B. S. (1979) · European Journal of Pharmacology · doi:10.1016/0014-2999(79)90283-8 · Cited by 391
Olianas, M. C., De Montis, G. M., Mulas, G., & Tagliamonte, A. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90098-5 · Cited by 268
Gale, K., & Iadarola, M. J. (1980) · Science · doi:10.1126/science.6768130 · Cited by 175
Self-citationEvidence for a GABAergic nigrothalamic pathway in the rat: II. Electrophysiological studies
MacLeod, N. K., James, T. A., Kilpatrick, I. C., & Starr, M. S. (1980) · Experimental Brain Research · doi:10.1007/bf00236662 · Cited by 174
HAYASHI, T. (1952) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.3.46 · Cited by 165
Effects of muscimol and picrotoxin on single unit activity of substantia nigra neurons
Waszczak, B. L., Eng, N., & Walters, J. R. (1980) · Brain Research · doi:10.1016/0006-8993(80)90567-3 · Cited by 162
ELECTROCLINICAL FEATURES OF CONVULSIONS INDUCED BY STIMULATION OF BRAIN STEM
Kreindler, A., Zuckermann, E. C., Steriade, M., et al. (1958) · Journal of Neurophysiology · doi:10.1152/jn.1958.21.5.430 · Cited by 145
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Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Anticonvulsant Mechanisms of the Ketogenic Diet
Bough, K. J., & Rho, J. M. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.00915.x · Cited by 523
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Dichter, M. A., & Ayala, G. F. (1987) · Science · doi:10.1126/science.3037700 · Cited by 437
GARCIARILL, E. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90016-t · Cited by 413
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Metadata
- Authors
- Iadarola, M. J., & Gale, K.
- Venue
- Science
- Published
- 1982-12-17
- Volume
- 218
- Issue
- 4578
- Pages
- 1237-1240
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023642970
- Cited by
- 592
- References
- 18
- FWCI
- 16.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- Iadarola, M. J., & Gale, K. (1982). Substantia Nigra: Site of Anticonvulsant Activity Mediated by γ-Aminobutyric Acid. Science. https://doi.org/10.1126/science.7146907
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
