The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Two Distinct Central Serotonin Receptors with Different Physiological Functions
Open accessAbstract
Two distinct serotonin (5-hydroxytryptamine) receptors designated serotonin 1 and serotonin 2 bind tritium-labeled serotonin and tritium-labeled spiroperidol, respectively. Drug potencies at serotonin 2 sites, but not at serotonin 1 sites, predict their effects on the "serotonin behavioral syndrome," indicating that serotonin 2 sites mediate these behaviors. The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase. Drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions, respectively.
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Citations
Cites
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220
Self-citationBennett, J. P., & Snyder, S. H. (1975) · Brain Research · doi:10.1016/0006-8993(75)90234-6 · Cited by 165
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Cited by
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., & Saxena, P. R. (1986) · Neuropharmacology · doi:10.1016/0028-3908(86)90207-8 · Cited by 1,258
The Meningeal Lymphatic System: A New Player in Neurophysiology
Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479
The Role of Serotonin in Schizophrenia
Bleich, A., Brown, S.-L., Kahn, R., & van Praag, H. M. (1988) · Schizophrenia Bulletin · doi:10.1093/schbul/14.2.297 · Cited by 371
Biegon, A., Reches, A., Snyder, L., & McEwen, B. S. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90053-x · Cited by 246
Glennon, R. A., Young, R., & Rosecrans, J. A. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90464-8 · Cited by 190
Metadata
- Authors
- Peroutka, S. J., Lebovitz, R. M., & Snyder, S. H.
- Venue
- Science
- Published
- 1981-05-15
- Volume
- 212
- Issue
- 4496
- Pages
- 827-829
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2060172635
- Cited by
- 637
- References
- 2
- FWCI
- 23.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Peroutka, S. J., Lebovitz, R. M., & Snyder, S. H. (1981). Two Distinct Central Serotonin Receptors with Different Physiological Functions. Science. https://doi.org/10.1126/science.7221567
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
