Antagonism of the effects of the hallucinogen dom and the purported 5-HT agonist quipazine by 5-HT2 antagonists

Glennon, Richard A.; Young, Richard; Rosecrans, John A.

doi:10.1016/0014-2999(83)90464-8

Cited by 192Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorHallucinations in medical conditions

Antagonism of the effects of the hallucinogen dom and the purported 5-HT agonist quipazine by 5-HT2 antagonists

Glennon, Richard A., Young, Richard, Rosecrans, John A.·1983·European Journal of Pharmacology

DOI 10.1016/0014-2999(83)90464-8

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Abstract

Rats trained to discriminate 1.0 mg/kg of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant choice task were administered doses of mescaline, LSD, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), quipazine, TFMPP and RU-24969. The DOM-stimulus generalized to the three hallucinogenic agents and to quipazine, but not to the purported serotonin agonists TFMPP or RU-24969. Pretreatment of the animals with the 5-HT2 antagonists ketanserin and pirenperone antagonized the effect produced by DOM. Pirenperone also blocked DOM-stimulus generalization to mescaline, LSD, 5-OMe DMT and quipazine. The results of this study suggest that the discriminative stimulus effects of DOM, the three hallucinogenic agents to which DOM-stimulus generalization occurred, and quipazine, may involve those sub-populations of serotonin receptors that are labeled by tritiated ketanserin (i.e. 5-HT2 sites).

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Authors: Glennon, R. A., Young, R., & Rosecrans, J. A.
Affiliations: Virginia Commonwealth University (US)
Corresponding author: Glennon, Richard A.
ORCID: Glennon, Richard A.
Young, Richard
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 1983-07
Volume: 91
Issue: 2-3
Pages: 189-196
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/0014-2999(83)90464-8
OpenAlex: W1983135802
Cited by: 190
References: 22
Citations by year: 2026: 5 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3
FWCI: 15.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Keywords: DOM, 5-HT2 receptor antagonist, quipazine, ketanserin, pirenperone, mescaline, LSD, hallucinogens, TFMPP, RU 24969, serotonin receptor agonists
MeSH terms: Amphetamines, Animals, DOM 2,5-Dimethoxy-4-Methylamphetamine, Ketanserin, Male, Piperidines, Quinolines, Quipazine, Rats, Inbred Strains, Serotonin Antagonists, Rats

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Antagonism of the effects of the hallucinogen dom and the purported 5-HT agonist quipazine by 5-HT2 antagonists

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