The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
The Role of Serotonin in Schizophrenia
Abstract
Studies examining serotonin (5-hydroxytryptamine; 5HT) in schizophrenia show variable and inconsistent findings, which might reflect the heterogeneity of the disease. When these studies are reviewed in the light of Crow's "two-syndrome" paradigm of schizophrenia, a new trend emerges. It appears that 5HT findings may be related to certain features of Type II schizophrenia such as negative symptoms, degenerative brain changes, and chronicity in the following manner: (1) 5HT2 antagonists, which have recently become available, have been shown to have an antipsychotic effect, particularly on the negative symptom cluster. (2) Decreased levels of 5-hydroxyindoleacetic acid in cerebrospinal fluid have been found to be correlated with cortical atrophy or ventricular enlargement in schizophrenic patients. (3) A subgroup of chronic schizophrenic patients has been shown to have elevated levels of platelet or whole blood 5HT. We propose, then, that 5HT dysfunction might be related to Type II, or negative syndrome, schizophrenia, and that the nature of this dysfunction might involve 5HT postsynaptic receptor hypersensitivity. We further suggest that the pharmacotherapy of schizophrenia should include a 5HT-blocking component, as well as a dopamine-blocking component, and we propose that future research should address the role of selective 5HT receptor hypersensitivity in schizophrenia.
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Citations
Cites
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Cited by
Amisulpride, an Unusual “Atypical” Antipsychotic: A Meta-Analysis of Randomized Controlled Trials
Leucht, S., Pitschel-Walz, G., Engel, R. R., & Kissling, W. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.2.180 · Cited by 470
Glucocorticoid hormones and early brain development in schizophrenia
Ph.D., J. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00396-7 · Cited by 199
Circadian rhythm of tryptophan, serotonin, melatonin, and pituitary hormones in schizophrenia
Rao, M. L., Gross, G., Strebel, B., Halaris, A., Huber, G., Bräunig, P., & Marler, M. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91147-9 · Cited by 154
Poland, R. E., Cloak, C., Lutchmansingh, P. J., McCracken, J. T., Chang, L., & Ernst, T. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00043-0 · Cited by 37
Metadata
- Authors
- Bleich, A., Brown, S.-L., Kahn, R., & van Praag, H. M.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 1988-01-01
- Volume
- 14
- Issue
- 2
- Pages
- 297-315
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- OpenAlex
- W2118527319
- Cited by
- 371
- References
- 94
- FWCI
- 9.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bleich, A., Brown, S.-L., Kahn, R., & van Praag, H. M. (1988). The Role of Serotonin in Schizophrenia. Schizophrenia Bulletin. https://doi.org/10.1093/schbul/14.2.297
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
