The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Role of NO Production in NMDA Receptor-Mediated Neurotransmitter Release in Cerebral Cortex
Abstract
L-Glutamate and norepinephrine are examples of a major excitatory neurotransmitter and a neuromodulator in the cerebral cortex, respectively. Little is known of how chemical signaling between the anatomically distinct chemical pathways occurs. Specific activation of the N -methyl-D-aspartate (NMDA) class of glutamate receptor in synaptosomal preparations from guinea pig cerebral cortex caused release of both of these chemicals, and this release was blocked by agents that inhibit nitric oxide (NO) production or remove NO from the extracellular space. Furthermore, neurotransmitter release correlated with cortical NO production after NMDA receptor stimulation. These results suggest that NO production and its extracellular movement may be links in the pathway from NMDA receptor activation to changes in chemical signaling in surrounding synaptic terminals in the cerebral cortex.
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Self-citationBright and dark sides of nitric oxide in ischemic brain injury
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Metadata
- Authors
- Montague, P. R., Gancayco, C. D., Winn, M. J., Marchase, R. B., & Friedlander, M. J.
- Venue
- Science
- Published
- 1994-02-18
- Volume
- 263
- Issue
- 5149
- Pages
- 973-977
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012038403
- Cited by
- 468
- References
- 62
- FWCI
- 21.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Montague, P. R., Gancayco, C. D., Winn, M. J., Marchase, R. B., & Friedlander, M. J. (1994). Role of NO Production in NMDA Receptor-Mediated Neurotransmitter Release in Cerebral Cortex. Science. https://doi.org/10.1126/science.7508638
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
