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The Fas Death Factor
Abstract
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.
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“FASLG induces cell death by binding to its receptor, FAS, leading to caspase-dependant apoptosis [16, 17].”
From MicroRNA‐21 protects neurons from ischemic death (2010) · cites this paper as [17]
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Fas (APO-1, CD95)-Mediated Apoptosis in Thyroid Cells Is Regulated by a Labile Protein Inhibitor
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Circulating soluble Fas concentration in breast cancer patients.
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Effect of tauroursodeoxycholic acid on bile acid‐induced apoptosis in primary human hepatocytes
Benz, Angermüller, Otto, Sauer, Stremmel, W., & Stiehl (2000) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2000.00615.x · Cited by 83
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Metadata
- Authors
- Nagata, S., & Golstein, P.
- Venue
- Science
- Published
- 1995-03-10
- Volume
- 267
- Issue
- 5203
- Pages
- 1449-1456
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041466047
- Cited by
- 3,979
- References
- 140
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 29 · 2023: 15 · 2022: 29 · 2021: 32 · 2020: 31 · 2019: 28 · 2018: 36 · 2017: 45 · 2016: 36 · 2015: 53 · 2014: 51 · 2013: 51 · 2012: 66
- FWCI
- 30.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- Fas ligand, Fas, apoptosis, tumor necrosis factor family, T cell cytotoxicity, immune regulation, lymphoproliferative disorders, autoimmune disease, tissue destruction
- MeSH terms
- Amino Acid Sequence, Animals, Antigens, Surface, Autoimmune Diseases, Base Sequence, Cytotoxicity, Immunologic, Humans, Lymphocyte Activation, Lymphocytes, Lymphoproliferative Disorders, Membrane Glycoproteins, Molecular Sequence Data, T-Lymphocytes, Cytotoxic, Down-Regulation, Apoptosis, fas Receptor, Fas Ligand Protein
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