Cited by 3,979Cell death mechanisms and regulationT-cell and B-cell ImmunologyCancer-related Molecular Pathways

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The Fas Death Factor

Nagata, Shigekazu, Golstein, Pierre·1995·Science

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Abstract

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction of the Fas system causes lymphoproliferative disorders and accelerates autoimmune diseases, whereas its exacerbation may cause tissue destruction.

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Authors: Nagata, S., & Golstein, P.
ORCID: Nagata, Shigekazu
Golstein, Pierre
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1995-03-10
Volume: 267
Issue: 5203
Pages: 1449-1456
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.7533326
OpenAlex: W2041466047
Cited by: 3,979
References: 140
Citations by year: 2026: 11 · 2025: 12 · 2024: 29 · 2023: 15 · 2022: 29 · 2021: 32 · 2020: 31 · 2019: 28 · 2018: 36 · 2017: 45 · 2016: 36 · 2015: 53 · 2014: 51 · 2013: 51 · 2012: 66
FWCI: 30.38
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: Fas ligand, Fas, apoptosis, tumor necrosis factor family, T cell cytotoxicity, immune regulation, lymphoproliferative disorders, autoimmune disease, tissue destruction
MeSH terms: Amino Acid Sequence, Animals, Antigens, Surface, Autoimmune Diseases, Base Sequence, Cytotoxicity, Immunologic, Humans, Lymphocyte Activation, Lymphocytes, Lymphoproliferative Disorders, Membrane Glycoproteins, Molecular Sequence Data, T-Lymphocytes, Cytotoxic, Down-Regulation, Apoptosis, fas Receptor, Fas Ligand Protein

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