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Cited by 1,067Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

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Jego, Gaetan, Palucka, A.Karolina, Blanck, Jean-Philippe, Chalouni, Cecile, Pascual, Virginia, Banchereau, Jacques·2003·Immunity
DOI 10.1016/s1074-7613(03)00208-5
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Abstract

Dendritic cells (DCs) initiate and control immune responses. Plasmacytoid DCs (pDCs) represent a unique DC subset able to promptly release large amounts of type I interferon (IFN-alphabeta) upon viral encounter. Here we report that depletion of pDCs from human blood mononuclear cells abrogates the secretion of specific and polyclonal IgGs in response to influenza virus. Furthermore, purified pDCs triggered with virus induce CD40-activated B cells to differentiate into plasma cells. Two pDC cytokines act sequentially, with IFN-alphabeta generating non-Ig-secreting plasma blasts and IL-6 inducing their differentiation into Ig-secreting plasma cells. These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses.

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  • IL-6 promotes antibody production by directly acting on plasma cells and by indirectly promoting Bcl6-dependent follicular CD4+ T (Tfh) cell differentiation together with IL-21.

    “Indeed, IL-6 promotes antibody production by directly acting on plasma cells and by indirectly promoting Bcl6-dependent follicular CD4(+) T (Tfh) cell differentiation together with IL-21 (Fig. 2) (143–146).”

    From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [144]

    The Results (Figure 5) show that IL-6 helps activated B cells become Ig-secreting plasma cells and that blocking IL-6 reduces IgG secretion; in these experiments, IL-6 acts with type I interferon. The paper does not support the attributed mechanism involving Bcl6-dependent Tfh-cell differentiation or IL-21. Page numbers are not available in our copy. (LLM, conf=0.90)

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Cited by

Sorted by citations

Authors
Jego, G., Palucka, A. K., Blanck, J.-P., Chalouni, C., Pascual, V., & Banchereau, J.
Corresponding author
Banchereau, Jacques
ORCID
Venue
Immunity
Publisher
Elsevier BV
Published
2003-08
Volume
19
Issue
2
Pages
225-234
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/s1074-7613(03)00208-5
OpenAlex
W2106566281
Cited by
1,067
References
3
Citations by year
2026: 17 · 2025: 31 · 2024: 29 · 2023: 46 · 2022: 42 · 2021: 49 · 2020: 34 · 2019: 41 · 2018: 42 · 2017: 32 · 2016: 41 · 2015: 48 · 2014: 47 · 2013: 61 · 2012: 62
FWCI
15.62
Type
journal article
Language
en
Open access
Licence
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (R01 CA78846, R01CA078846)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR046589, R0-1-AR46589)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
plasmacytoid dendritic cells, plasma cell differentiation, type I interferon, interleukin-6, influenza virus, antibody response, IgG secretion, plasmablasts, CD38, B cell differentiation
MeSH terms
Adult, B-Lymphocytes, Cell Communication, Cell Differentiation, Dendritic Cells, Humans, Immunoglobulins, Interferon Type I, Lymphocyte Activation, Plasma Cells, Interleukin-6, CD40 Antigens, In Vitro Techniques

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