The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy
Abstract
Combinations of antiretroviral drugs that prevent or delay the appearance of drug-resistant human immunodeficiency virus-type 1 (HIV-1) mutants are urgently required. Mutants resistant to 3′-azidothymidine (AZT, zidovudine) became phenotypically sensitive in vitro by mutation of residue 184 of viral reverse transcriptase to valine, which also induced resistance to (-)2′-deoxy-3′-thiacytidine (3TC). Furthermore, AZT-3TC coresistance was not observed during extensive in vitro selection with both drugs. In vivo AZT-3TC combination therapy resulted in a markedly greater decrease in serum HIV-1 RNA concentrations than treatment with AZT alone, even though valine-184 mutants rapidly emerged. Most samples assessed from the combination group remained AZT sensitive at 24 weeks of therapy, consistent with in vitro mutation studies.
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Cites
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Analysis of drug combinations: current methodological landscape
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Multicomponent therapeutics for networked systems
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Virus dynamics and drug therapy
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A robustness-based approach to systems-oriented drug design
Kitano, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2195 · Cited by 488
Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase
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Metadata
- Authors
- Larder, B. A., Kemp, S. D., & Harrigan, P. R.
- Venue
- Science
- Published
- 1995-08-04
- Volume
- 269
- Issue
- 5224
- Pages
- 696-699
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035938088
- Cited by
- 623
- References
- 24
- FWCI
- 54.33
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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