The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Regulated Subcellular Distribution of the NR1 Subunit of the NMDA Receptor
Abstract
NMDA ( N -methyl -D-aspartate) receptors are selectively localized at the postsynaptic membrane of excitatory synapses in the mammalian brain. The molecular mechanisms underlying this localization were investigated by expressing the NR1 subunit of the NMDA receptor in fibroblasts. NR1 splice variants containing the first COOH-terminal exon cassette (NR1A and NR1D) were located in discrete, receptor-rich domains associated with the plasma membrane. NR1 splice variants lacking this exon cassette (NR1C and NR1E) were distributed throughout the cell, with large amounts of NR1 protein present in the cell interior. Insertion of this exon cassette into the COOH-terminus of the GluR1 AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor was sufficient to cause GluR1 to be localized to discrete, receptor-rich domains. Furthermore, protein kinase C phosphorylation of specific serines within this exon disrupted the receptor-rich domains. These results demonstrate that amino acid sequences contained within the NR1 molecule serve to localize this receptor subunit to discrete membrane domains in a manner that is regulated by alternative splicing and protein phosphorylation.
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Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Molecular cloning and characterization of the rat NMDA receptor
Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1991) · Nature · doi:10.1038/354031a0 · Cited by 1,771
Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., & Jan, L. Y. (1994) · Nature · doi:10.1038/368144a0 · Cited by 1,377
Patterned Activity, Synaptic Convergence, and the NMDA Receptor in Developing Visual Pathways
Constantine-Paton, M., Cline, H. T., & Debski, E. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001021 · Cited by 784
Calcium-induced actin depolymerization reduces NMDA channel activity
Rosenmund, C., & Westbrook, G. L. (1993) · Neuron · doi:10.1016/0896-6273(93)90197-y · Cited by 503
Huntley, G., Vickers, J., Janssen, W., Brose, N., Heinemann, S., & Morrison, J. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03603.1994 · Cited by 161
Cited by
The Glutamate Receptor Ion Channels
Dingledine, R., Borges, K., Bowie, D., & Traynelis, S. F. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01394-2 · Cited by 3,554
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
Dong, H., O'Brien, R. J., Fung, E. T., Lanahan, A. A., Worley, P. F., & Huganir, R. L. (1997) · Nature · doi:10.1038/386279a0 · Cited by 871
Self-citationDanysz, W., & Parsons, C. G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01382-6 · Cited by 649
Competitive binding of α-actinin and calmodulin to the NMDA receptor
Wyszynski, M., Lin, J., Rao, A., Nigh, E., Beggs, A. H., Craig, A. M., & Sheng, M. (1997) · Nature · doi:10.1038/385439a0 · Cited by 596
Molecular Mechanisms of Glutamate Receptor-Mediated Excitotoxic Neuronal Cell Death
Sattler, R., & Tymianski, M. (2001) · Molecular Neurobiology · doi:10.1385/mn:24:1-3:107 · Cited by 537
Metadata
- Authors
- Ehlers, M. D., Tingley, W. G., & Huganir, R. L.
- Venue
- Science
- Published
- 1995-09-22
- Volume
- 269
- Issue
- 5231
- Pages
- 1734-1737
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025700116
- Cited by
- 293
- References
- 6
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
