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Cited by 969

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

Ohno, Hiroshi, Stewart, Jay, Fournier, Marie-Christine, Bosshart, Herbert, Rhee, Ina, Miyatake, Shoichiro, Saito, Takashi, Gallusser, Andreas, Kirchhausen, Tomas, Bonifacino, Juan S.·1995·Science

Abstract

Tyrosine-based signals within the cytoplasmic domain of integral membrane proteins mediate clathrin-dependent protein sorting in the endocytic and secretory pathways. A yeast two-hybrid system was used to identify proteins that bind to tyrosine-based signals. The medium chains (μ 1 and μ 2 ) of two clathrin-associated protein complexes (AP-1 and AP-2, respectively) specifically interacted with tyrosine-based signals of several integral membrane proteins. The interaction was confirmed by in vitro binding assays. Thus, it is likely that the medium chains serve as signal-binding components of the clathrin-dependent sorting machinery.

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Crossref · 10.1126/science.7569928

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Metadata

Authors
Ohno, H., Stewart, J., Fournier, M.-C., Bosshart, H., Rhee, I., Miyatake, S., Saito, T., Gallusser, A., Kirchhausen, T., & Bonifacino, J. S.
Venue
Science
Published
1995-09-29
Volume
269
Issue
5232
Pages
1872-1875
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1979815209
Cited by
969
References
1
FWCI
26.75
Type
journal article
Language
en
Open access
closed

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