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Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element
Abstract
The ternary complex factor (TCF) subfamily of ETS-domain transcription factors bind with serum response factor (SRF) to the serum response element (SRE) and mediate increased gene expression. The TCF protein Elk-1 is phosphorylated by the JNK and ERK groups of mitogen-activated protein (MAP) kinases causing increased DNA binding, ternary complex formation, and transcriptional activation. Activated SRE-dependent gene expression is induced by JNK in cells treated with interleukin-1 and by ERK after treatment with phorbol ester. The Elk-1 transcription factor therefore integrates MAP kinase signaling pathways in vivo to coordinate biological responses to different extracellular stimuli.
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Self-citation
Metadata
- Authors
- Whitmarsh, A. J., Shore, P., Sharrocks, A. D., & Davis, R. J.
- Venue
- Science
- Published
- 1995-07-21
- Volume
- 269
- Issue
- 5222
- Pages
- 403-407
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002282120
- Cited by
- 932
- References
- 2
- FWCI
- 33.99
- Type
- journal article
- Language
- en
- Open access
- closed
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