Cell-Permeable Peptide Inhibitors of JNK

Bonny, Christophe; Oberson, Anne; Negri, Stéphanie; Sauser, Christelle; Schorderet, Daniel F.

doi:10.2337/diabetes.50.1.77

Cited by 571Pancreatic function and diabetesProtein Kinase Regulation and GTPase SignalingChemical Synthesis and Analysis

Cell-Permeable Peptide Inhibitors of JNK

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Bonny, Christophe, Oberson, Anne, Negri, Stéphanie, Sauser, Christelle, Schorderet, Daniel F.·2001·Diabetes

DOI 10.2337/diabetes.50.1.77

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Abstract

Stress conditions and proinflammatory cytokines activate the c-Jun NH2-terminal kinase (JNK), a member of the stress-activated group of mitogen-activated protein kinases (MAPKs). We recently demonstrated that inhibition of JNK signaling with the use of the islet-brain (IB) 1 and 2 proteins prevented interleukin (IL)-1β—induced pancreatic β-cell death. Bioactive cell-permeable peptide inhibitors of JNK were engineered by linking the minimal 20-amino acid inhibitory domains of the IB proteins to the 10-amino acid HIV-TAT sequence that rapidly translocates inside cells. Kinase assays indicate that the inhibitors block activation of the transcription factor c-Jun by JNK. Addition of the peptides to the insulin-secreting βTC-3 cell line results in a marked inhibition of IL-1β—induced c-jun and c-fos expression. The peptides protect βTC-3 cells against apoptosis induced by IL-1β. All-D retro-inverso peptides penetrate cells as efficiently as the L-enantiomers, decrease c-Jun activation by JNK, and remain highly stable inside cells. These latter peptides confer full protection against IL-1β—induced apoptosis for up to 2 weeks of continual treatment with IL-1β. These data establish these bioactive cell-permeable peptides as potent pharmacological compounds that decrease intracellular JNK signaling and confer long-term protection to pancreatic β-cells from IL-1β—induced apoptosis.

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The minimal JNK-binding region of JIP1 (pepJIP1) inhibits JNK activity in vitro toward c-jun, Elk, and ATF2 up to 90% with selectivity over Erk and p38.
“This peptide, pepJIP1 (a peptide version of JIP1), inhibited JNK activity in vitro toward recombinant c-jun, Elk, and ATF2 up to 90% with significant selectivity of no inhibition of the related Erk and p38 MAPKs.”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bonny et al , 2001

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Authors: Bonny, C., Oberson, A., Negri, S., Sauser, C., & Schorderet, D. F.
Affiliations: Centre Hospitalier Universitaire Vaudois (CH)
From the Division of Medical Genetics, Centre Hospitalier Universitaire Vaudois—University Hospital, 1011 Lausanne, Switzerland.
ORCID: Bonny, Christophe
Schorderet, Daniel F.
Venue: Diabetes
Publisher: American Diabetes Association
Published: 2001-01-01
Volume: 50
Issue: 1
Pages: 77-82
ISSN: 0012-1797 (ISSN-L)
1939-327X
DOI: 10.2337/diabetes.50.1.77
OpenAlex: W2059995799
Cited by: 571
References: 46
Citations by year: 2026: 2 · 2025: 3 · 2024: 9 · 2023: 14 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 7 · 2018: 11 · 2017: 16 · 2016: 17 · 2015: 13 · 2014: 21 · 2013: 19 · 2012: 25
FWCI: 35.95
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Diabetes (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
Keywords: JNK inhibition, cell-permeable peptide, c-Jun activation, pancreatic beta-cell destruction, retro-inverso peptides, Fos expression, peptide stability
MeSH terms: Amino Acid Sequence, Cell Line, Cell Membrane Permeability, Enzyme Inhibitors, Humans, Interleukin-1, Islets of Langerhans, Molecular Sequence Data, Nuclear Proteins, Peptides, Trans-Activators, Proto-Oncogene Proteins c-jun, Proto-Oncogene Proteins c-fos, Cell Death, Conserved Sequence, Apoptosis, Mitogen-Activated Protein Kinases, JNK Mitogen-Activated Protein Kinases, Adaptor Proteins, Signal Transducing

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Cell-Permeable Peptide Inhibitors of JNK

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