The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)
Abstract
T cell hybridomas require the immediate-early gene NGFI-B ( nur77 ) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells. TCR-mediated death was examined in mice bearing an NGFI-B loss-of-function mutation, either by administration of antibodies to CD3 (anti-CD3) or in two well-characterized transgenic models expressing self-reactive TCRs. Both the extent and the rate of thymocyte death were unimpaired. Anti-CD3-induced death was normal in CD4 + peripheral T cells, in which death is mediated predominantly by the Fas signaling pathway. Thus, no unique requirement for NGFI-B is observed for thymic or peripheral T cell death.
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Cited by
Positive and negative selection of T cells
Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141107 · Cited by 1,601
Nuclear Receptor Expression Links the Circadian Clock to Metabolism
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The NR4A Subgroup: Immediate Early Response Genes with Pleiotropic Physiological Roles
Maxwell, M. A., & Muscat, G. E. O. (2006) · Nuclear Receptor Signaling · doi:10.1621/nrs.04002 · Cited by 448
Metadata
- Authors
- Lee, S. L., Wesselschmidt, R. L., Linette, G. P., Kanagawa, O., Russell, J. H., & Milbrandt, J.
- Venue
- Science
- Published
- 1995-07-28
- Volume
- 269
- Issue
- 5223
- Pages
- 532-535
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975672275
- Cited by
- 273
- References
- 24
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lee, S. L., Wesselschmidt, R. L., Linette, G. P., Kanagawa, O., Russell, J. H., & Milbrandt, J. (1995). Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77). Science. https://doi.org/10.1126/science.7624775
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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