The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C- monocytes
Open accessAbstract
The transcription factors that regulate differentiation into the monocyte subset in bone marrow have not yet been identified. Here we found that the orphan nuclear receptor NR4A1 controlled the differentiation of Ly6C- monocytes. Ly6C- monocytes, which function in a surveillance role in circulation, were absent from Nr4a1-/- mice. Normal numbers of myeloid progenitor cells were present in Nr4a1-/- mice, which indicated that the defect occurred during later stages of monocyte development. The defect was cell intrinsic, as wild-type mice that received bone marrow from Nr4a1-/- mice developed fewer patrolling monocytes than did recipients of wild-type bone marrow. The Ly6C- monocytes remaining in the bone marrow of Nr4a1-/- mice were arrested in S phase of the cell cycle and underwent apoptosis. Thus, NR4A1 functions as a master regulator of the differentiation and survival of 'patrolling' Ly6C- monocytes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Depletion of Ly6Clo monocytes by Nr4a1 deletion corresponded with increased Aβ deposits in cortex and hippocampus.
“Depletion of these cells by deletion of Nr4a1, a transcription factor controlling the differentiation and survival of Ly6Clo monocytes [144], corresponded with increased Aβ deposits in the cortex and hippocampus [227]”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [144]
Compared to monocytes, iMGLs express myeloid genes RUNX1, PU.1, and CSF1R but do not express monocyte-specific transcription factors IRF1, KLF4, and NR4A1.
“When compared to monocytes, iMGLs express the myeloid genes, RUNX1, PU.1, and CSF1R (Figure S3C), but do not express monocyte-specific transcription factors, IRF1, KLF4, NR4A1 (Abdollahi et al., 1991; Hanna et al., 2011; Lavin et al., 2014) (Figure S3D).”
From iPSC-derived human microglia-like cells to study neurological diseases (2017) · cites this paper as Hanna et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
Self-citationDevelopment of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Self-citationNahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002 · see citing works
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Auffray, C., Fogg, D., Garfa, M., Elain, G., Join-Lambert, O., Kayal, S., Sarnacki, S., Cumano, A., Lauvau, G., & Geissmann, F. (2007) · Science · doi:10.1126/science.1142883 · Cited by 1,973 · see citing works
Self-citationBlood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells
Auffray, C., Sieweke, M. H., & Geissmann, F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132557 · Cited by 1,647 · see citing works
Self-citationTacke, F., Alvarez, D., Kaplan, T. J., Jakubzick, C., Spanbroek, R., Llodra, J., Garin, A., Liu, J., Mack, M., van Rooijen, N., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28549 · Cited by 1,323 · see citing works
Świrski, F. K., Libby, P., Aikawa, E. R., Alcaide, P., Luscinskas, F. W., Weissleder, R., & Pittet, M. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29950 · Cited by 1,258 · see citing works
Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors
Cros, J. F., Cagnard, N., Woollard, K. J., Patey, N., Zhang, S., Sénéchal, B., Puel, A., Biswas, S. K., Moshous, D., Pïcard, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.012 · Cited by 1,251 · see citing works
Self-citationMonocyte-Mediated Defense Against Microbial Pathogens
Serbina, N. V., Jia, T., Hohl, T. M., & Pamer, E. G. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090326 · Cited by 1,116 · see citing works
Moran, A. E., Holzapfel, K. L., Xing, Y., Cunningham, N. R., Maltzman, J. S., Punt, J. A., & Hogquist, K. A. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110308 · Cited by 1,035 · see citing works
Self-citationMonocytes in atherosclerosis: subsets and functions
Woollard, K. J., & Geissmann, F. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.228 · Cited by 890 · see citing works
Self-citationShechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000113 · Cited by 770 · see citing works
Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3
Lin, B., Kolluri, S. K., Lin, F., Liu, W., Han, Y.-H., Cao, X., Dawson, M. I., Reed, J. C., & Zhang, X.-K. (2004) · Cell · doi:10.1016/s0092-8674(04)00162-x · Cited by 672 · see citing works
Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3
Li, H., Kolluri, S. K., Gu, J., Dawson, M. I., Cao, X., Hobbs, P. D., Lin, B., Chen, G.-Q., Lu, J.-S., Lin, F., et al. (2000) · Science · doi:10.1126/science.289.5482.1159 · Cited by 668 · see citing works
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
Varol, C., Landsman, L., Fogg, D. K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F., & Jung, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061011 · Cited by 627 · see citing works
Self-citationStructure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
Wang, Z., Benoit, G., Liu, J., Prasad, S., Aarnisalo, P., Liu, X., Xu, H., Walker, N. P. C., & Perlmann, T. (2003) · Nature · doi:10.1038/nature01645 · Cited by 583 · see citing works
Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast
Wilson, T. E., Fahrner, T. J., Johnston, M., & Milbrandt, J. (1991) · Science · doi:10.1126/science.1925541 · Cited by 557 · see citing works
Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
Woronicz, J. D., Calnan, B. J., Ngo, V. N., & Winoto, A. (1994) · Nature · doi:10.1038/367277a0 · Cited by 555 · see citing works
Inflammatory Chemokine Transport and Presentation in HEV
Palframan, R. T., Jung, S., Cheng, G., Weninger, W., Luo, Y., Dorf, M. E., Littman, D. R., Rollins, B. J., Zweerink, H. J., Rot, A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1361 · Cited by 551 · see citing works
Hazel, T. G., Nathans, D., & Lau, L. F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.22.8444 · Cited by 514 · see citing works
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival
Landsman, L., Bar‐On, L., Zernecke, A., Kim, K.-W., Krauthgamer, R., Shagdarsuren, E., Lira, S. A., Weissman, I. L., Weber, C., & Jung, S. (2008) · Blood · doi:10.1182/blood-2008-07-170787 · Cited by 490 · see citing works
Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice
Mack, M., Cihak, J., Simonis, C., Luckow, B., Proudfoot, A. E. I., Plachý, J., Brühl, H., Frink, M., Anders, H., Vielhauer, V., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4697 · Cited by 459 · see citing works
Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081385 · Cited by 422 · see citing works
Self-citationRw, L., Bc, V., & Hr, H. (1987) · PubMed · Cited by 359 · see citing works
Abrogation of nuclear receptors Nr4a3 andNr4a1 leads to development of acute myeloid leukemia
Mullican, S. E., Zhang, S., Konopleva, M. Y., Ruvolo, V. R., Andreeff, M., Milbrandt, J., & Conneely, O. M. (2007) · Nature Medicine · doi:10.1038/nm1579 · Cited by 323 · see citing works
Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung
Landsman, L., Varol, C., & Jung, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2000 · Cited by 322 · see citing works
Pei, L., Castrillo, A., Chen, M., Hoffmann, A., & Tontonoz, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502606200 · Cited by 282 · see citing works
Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)
Lee, S., Wesselschmidt, R. L., Linette, G. P., Kanagawa, O., Russell, J. H., & Milbrandt, J. (1995) · Science · doi:10.1126/science.7624775 · Cited by 271 · see citing works
Bonta, P. I., van Tiel, C. M., Vos, M., Pols, T. W. H., van Thienen, J. V., Ferreira, V., Arkenbout, E. K., Seppen, J., Spek, C. A., van der Poll, T., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000238346.84458.5d · Cited by 248 · see citing works
p53 and Nur77/TR3 – transcription factors that directly target mitochondria for cell death induction
Moll, U. M., Marchenko, N. D., & Zhang, X.-K. (2006) · Oncogene · doi:10.1038/sj.onc.1209601 · Cited by 241 · see citing works
The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway
Baker, K. D., Shewchuk, L. M., Kozlova, T., Makishima, M., Hassell, A. M., Wisely, B., Caravella, J. A., Lambert, M. H., Reinking, J. L., Krause, H. M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00420-3 · Cited by 238 · see citing works
Martínez‐González, J., & Badimón, L. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.10.002 · Cited by 167 · see citing works
Thompson, J., & Winoto, A. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080101 · Cited by 162 · see citing works
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells.
Zhou, T., Cheng, J., Yang, P., Wang, Z., Liu, C., Su, X., Bluethmann, H., & Mountz, J. D. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1879 · Cited by 162 · see citing works
Yrlid, U., Jenkins, C. D., & MacPherson, G. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4155 · Cited by 149 · see citing works
Protective Function of Transcription Factor TR3 Orphan Receptor in Atherogenesis
Arkenbout, E. K., de Waard, V., van Bragt, M. P. A., van Achterberg, T. A. E., Grimbergen, J. M., Pichon, B., Pannekoek, H., & de Vries, C. J. M. (2002) · Circulation · doi:10.1161/01.cir.0000028811.03056.bf · Cited by 148 · see citing works
Li, Q.-X., Ke, N., Sundaram, R., & Wong‐Staal, F. (2006) · PubMed · doi:10.14670/hh-21.533 · Cited by 141 · see citing works
Nurr1-RXR heterodimers mediate RXR ligand-induced signaling in neuronal cellsPreprint
Wallén‐Mackenzie, Å., de Urquiza, A. M., Petersson, S., Rodríguez, F. J., Friling, S., Wagner, J., Ordentlich, P., Lengqvist, J., Heyman, R. A., Arenas, E., et al. (2003) · Genes & Development · doi:10.1101/gad.276003 · Cited by 138 · see citing works
Fahrner, T. J., Carroll, S. L., & Milbrandt, J. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.12.6454 · Cited by 136 · see citing works
Randolph, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32830d5f09 · Cited by 128 · see citing works
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
Rajpal, A., Cho, Y. A., Yelent, B., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg620 · Cited by 125 · see citing works
You, B., Jiang, Y., Chen, S., Yan, G., & Sun, J. (2009) · Circulation Research · doi:10.1161/circresaha.108.192286 · Cited by 124 · see citing works
Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes
Narni-Mancinelli, É., Campisi, L., Bassand, D., Cazareth, J., Gounon, P., Glaichenhaus, N., & Lauvau, G. S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070204 · Cited by 106 · see citing works
Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice
Ramirez-Herrick, A. M., Mullican, S. E., Sheehan, A. M., & Conneely, O. M. (2011) · Blood · doi:10.1182/blood-2010-02-267906 · Cited by 96 · see citing works
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
Sirin, O., Lukov, G. L., Mao, R., Conneely, O. M., & Goodell, M. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2125 · Cited by 96 · see citing works
Epstein–Barr virus EBNA2 blocks Nur77- mediated apoptosis
Lee, J. M., Lee, K.-H., Weidner-Glunde, M., Osborne, B. A., & Hayward, S. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182552499 · Cited by 95 · see citing works
E2F2 represses cell cycle regulators to maintain quiescence
Infante, A., Laresgoiti, U., Fernández‐Rueda, J., Fullaondo, A., Galán, J., Díaz‐Uriarte, R., Malumbres, M., Field, S. J., & Zubiaga, A. M. (2008) · Cell Cycle · doi:10.4161/cc.7.24.7379 · Cited by 70 · see citing works
Bonta, P. I., Matlung, H. L., Vos, M., Peters, S. L. M., Pannekoek, H., Bakker, E. N. T. P., & de Vries, C. J. M. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq064 · Cited by 44 · see citing works
E2f1–3 Are Critical for Myeloid Development
Trikha, P., Sharma, N., Opavský, R., Reyes, A., Pena, C., Ostrowski, M. C., Roussel, M. F., & Leone, G. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.182733 · Cited by 37 · see citing works
Cutting Edge: Identification of the Targets of Clonal Deletion in an Unmanipulated Thymus
Cho, H. J., Edmondson, S., Miller, A. D., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.10 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
Macrophages in atherosclerosis: a dynamic balance
Moore, K. J., Sheedy, F. J., & Fisher, E. A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3520 · Cited by 2,559 · see citing works
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067 · see citing works
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
Liver Macrophages in Tissue Homeostasis and Disease
Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424 · see citing works
iPSC-derived human microglia-like cells to study neurological diseases
Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.042 · Cited by 1,154 · see citing works
Monocyte differentiation and antigen-presenting functions
Jakubzick, C. V., Randolph, G. J., & Henson, P. M. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.28 · Cited by 910 · see citing works
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19
Silvin, A., Chapuis, N., Dunsmore, G., Goubet, A.-G., Dubuisson, A., Derosa, L., Almire, C., Hénon, C., Kosmider, O., Droin, N., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.002 · Cited by 834 · see citing works
Pombo Antunes, A. R., Scheyltjens, I., Lodi, F., Messiaen, J., Antoranz, A., Duerinck, J., Kancheva, D., Martens, L., De Vlaminck, K., Van Hove, H., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00789-y · Cited by 704 · see citing works
Monocyte-macrophages and T cells in atherosclerosis
Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646 · see citing works
Macrophage phenotypes in atherosclerosis
Colin, S., Chinetti‐Gbaguidi, G., & Staels, B. (2014) · Immunological Reviews · doi:10.1111/imr.12218 · Cited by 657 · see citing works
Wohleb, E. S., Powell, N. D., Godbout, J. P., & Sheridan, J. F. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1671-13.2013 · Cited by 563 · see citing works
Yáñez, A., Coetzee, S. G., Olsson, A., Muench, D. E., Berman, B. P., Hazelett, D. J., Salomonis, N., Grimes, H. L., & Goodridge, H. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.021 · Cited by 470 · see citing works
Blériot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.020 · Cited by 471 · see citing works
The UK-PSCSC Consortium, Liu, J. Z., The International IBD Genetics Consortium, The International PSC Study Group, Hov, J. R., Folseraas, T., Ellinghaus, E., Rushbrook, S. M., Doncheva, N. T., Andreassen, O. A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2616 · Cited by 391 · see citing works
Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design
Ogle, M. E., Segar, C. E., Sridhar, S., & Botchwey, E. A. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216650293 · Cited by 378 · see citing works
Identification of an atypical monocyte and committed progenitor involved in fibrosis
Satoh, T., Nakagawa, K., Sugihara, F., Kuwahara, R., Ashihara, M., Yamane, F., Minowa, Y., Fukushima, K., Ebina, I., Yoshioka, Y., et al. (2017) · Nature · doi:10.1038/nature20611 · Cited by 302 · see citing works
Baeck, C., Wei, X., Bartneck, M., Fech, V., Heymann, F., Gassler, N., Hittatiya, K., Eulberg, D., Luedde, T., Trautwein, C., et al. (2014) · Hepatology · doi:10.1002/hep.26783 · Cited by 270 · see citing works
Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta
Michaud, J.-P., Bellavance, M.-A., Préfontaine, P., & Rivest, S. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.010 · Cited by 257 · see citing works
Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation
Kurotaki, D., Osato, N., Nishiyama, A., Yamamoto, M., Ban, T., Sato, H., Nakabayashi, J., Umehara, M., Miyake, N., Matsumoto, N., et al. (2013) · Blood · doi:10.1182/blood-2012-06-437863 · Cited by 252 · see citing works
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216 · see citing works
“Depletion of these cells by deletion of Nr4a1, a transcription factor controlling the differentiation and survival of Ly6Clo monocytes [144], corresponded with increased Aβ deposits in the cortex and hippocampus [227], implicating a critical role for vascular Aβ clearance by patrolling monocytes.”
BackgroundDevelopment and homeostasis of “resident” myeloid cells: the case of the microglia
Gomez Perdiguero, E., Schulz, C., & Geissmann, F. (2013) · Glia · doi:10.1002/glia.22393 · Cited by 182 · see citing works
Self-citationChong, S. Z., Evrard, M., Devi, S., Chen, J., Lim, J. Y., See, P., Zhang, Y., Adrover, J. M., Lee, B., Tan, L., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160800 · Cited by 142 · see citing works
Rodríguez-Calvo, R., Tajes, M., & Vázquez-Carrera, M. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1279146 · Cited by 117 · see citing works
Yeo, G. H. T., Saksena, S. D., & Gifford, D. K. (2021) · Nature Communications · doi:10.1038/s41467-021-23518-w · Cited by 103 · see citing works
Quintar, A., McArdle, S., Wolf, D., Marki, A., Ehinger, E., Vassallo, M., Miller, J., Mikulski, Z., Ley, K., & Buscher, K. (2017) · Circulation Research · doi:10.1161/circresaha.117.310739 · Cited by 109 · see citing works
The Translational Potential of Microglia and Monocyte-Derived Macrophages in Ischemic Stroke
Wicks, E. E., Ran, K. R., Kim, J. E., Xu, R., Lee, R. P., & Jackson, C. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.897022 · Cited by 92 · see citing works
Protective features of peripheral monocytes/macrophages in stroke
Gliem, M., Schwaninger, M., & Jander, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.004 · Cited by 88 · see citing works
Murphy, E., & Crean, D. (2015) · Biomolecules · doi:10.3390/biom5031302 · Cited by 82 · see citing works
Fungal dissemination is limited by liver macrophage filtration of the blood
Sun, D., Sun, P., Li, H., Zhang, M., Liu, G., Strickland, A. B., Chen, Y., Fu, Y., Xu, J., Yosri, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12381-5 · Cited by 83 · see citing works
The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou, X., Chen, G., Bracamonte-Baran, W., Choi, H. S., Diny, N. L., Sung, J., Hughes, D., Won, T., Wood, M. K., Talor, M. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.007 · Cited by 83 · see citing works
Lessard, A.-J., LeBel, M., Egarnes, B., Préfontaine, P., Thériault, P., Droit, A., Brunet, A., Rivest, S., & Gosselin, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.009 · Cited by 70 · see citing works
HO-1hi patrolling monocytes protect against vaso-occlusion in sickle cell disease
Liu, Y., Jing, F., Yi, W., Mendelson, A., Shi, P., Walsh, R., Friedman, D. F., Minniti, C., Manwani, D., Chou, S. T., et al. (2018) · Blood · doi:10.1182/blood-2017-12-819870 · Cited by 51 · see citing works
Liu, G., Fu, Y., Yosri, M., Chen, Y., Sun, P., Xu, J., Zhang, M., Sun, D., Strickland, A. B., Mackey, Z. B., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913443116 · Cited by 43 · see citing works
Terry, R. L., Deffrasnes, C., Getts, D. R., Minten, C., van Vreden, C., Ashhurst, T. M., Getts, M. T., Xie, R. D. V., Campbell, I. L., & King, N. J. C. (2015) · Journal of Innate Immunity · doi:10.1159/000365972 · Cited by 40 · see citing works
Sun, D., Zhang, M., Sun, P., Liu, G., Strickland, A. B., Chen, Y., Fu, Y., Yosri, M., & Shi, M. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008361 · Cited by 34 · see citing works
- Authors
- Hanna, R. N., Carlin, L. M., Hubbeling, H. G., Nackiewicz, D., Green, A. M., Punt, J. A., Geissmann, F., & Hedrick, C. C.
- Affiliations
- La Jolla Institute for Immunology (US)
- King's College London (GB)
- Haverford College (US)
- Corresponding author
- Hedrick, Catherine C
- Venue
- Nature Immunology
- Published
- 2011-07-03
- Volume
- 12
- Issue
- 8
- Pages
- 778-785
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC3324395
- OpenAlex
- W2151362823
- Cited by
- 639
- References
- 51
- Citations by year
- 2026: 27 · 2025: 32 · 2024: 37 · 2023: 49 · 2022: 43 · 2021: 50 · 2020: 53 · 2019: 51 · 2018: 47 · 2017: 64 · 2016: 37 · 2015: 54 · 2014: 49 · 2013: 23 · 2012: 18
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institutes of Health (5r01hl071141-08)
- National Heart, Lung, and Blood Institute (R01HL079621, R01- HL071141)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- Nur77, Ly6C+ monocytes, non-classical monocytes, monocyte differentiation, bone marrow, transcription factors, apoptosis, cell cycle arrest, myeloid progenitor cells, orphan nuclear receptor
- MeSH terms
- Animals, Antigens, Ly, Bone Marrow, Cell Cycle, Cell Differentiation, DNA Damage, Flow Cytometry, Mice, Inbred C57BL, Monocytes, RNA, Messenger, Specific Pathogen-Free Organisms, Apoptosis, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Mice, Nuclear Receptor Subfamily 4, Group A, Member 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
