Candidate gene for the chromosome 1 familial Alzheimer’s disease locus

Levy-Lahad, Ephrat, Wasco, Wilma, Poorkaj, Parvoneh, Romano, Donna M., Oshima, Junko, Pettingell, Warren H., Yu, Chang-en, Jondro, Paul D., Schmidt, Stephen D., Wang, Kai, Crowley, Annette C., Fu, Ying-Hui, Guenette, Suzanne Y., Galas, David, Nemens, Ellen, Wijsman, Ellen M., Bird, Thomas D., Schellenberg, Gerard D., Tanzi, Rudolph E.·1995·Science
DOI 10.1126/science.7638622

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Items 901–1,000 of 1,015

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    Shekar Mekala, Grady L. Nelson, Yue‐Ming Li · 2020 · RSC Medicinal Chemistry
  2. Identification of a novel 4.6-kb genomic deletion in presenilin-1 gene which results in exclusion of exon 9 in a Finnish early onset Alzheimer's disease family: an Alu core sequence-stimulated recombination?
    Mikko Hiltunen, Seppo Helisalmi, Arto Mannermaa, Irina I. Alafuzoff, Anne Maria Koivisto, Maarit Lehtovirta, Mia M. Pirskanen, Raimo O. Sulkava, Auli Verkkoniemi, Hilkka S. Soininen · 2000 · European Journal of Human Genetics
  3. Developing Preventive Therapies for Chronic Diseases: Lessons Learned from Alzheimer's Disease
    Dennis J. Selkoe · 2008 · Nutrition Reviews
  4. The Genetics of Cognitive Processes: Candidate Genes in Humans and Animals
    Katherine I. Morley, Grant W. Montgomery · 2001 · Behavior Genetics
  5. Splicing mutation of presenilin-1 gene for early-onset familial Alzheimer's disease
    Shinji Sato, Kouzin Kamino, Tetsuro Miki, Akira Doi, Kunio Ii, Peter St George‐Hyslop, Toshio Ogihara, Yoshiyuki Sakaki · 1998 · Human Mutation
  6. Identification of a Novel PSD-95/Dlg/ZO-1 (PDZ)-like Protein Interacting with the C Terminus of Presenilin-1
    Xuemin Xu, Yong-chang Shi, Xian Wu, Pierluigi L. Gambetti, Dexin Sui, Mei‐Zhen Cui · 1999 · Journal of Biological Chemistry
  7. Is sleep disruption a risk factor for Alzheimer's disease?
    Macedo, Arthur Cassa, Balouch, Sara, Tabet, Naji · 2017 · Journal of Alzheimer’s Disease
  8. Inactivation of presenilins causes pre‐synaptic impairment prior to post‐synaptic dysfunction
    Dawei Zhang, Chen Zhang, Angela Ho, Alfredo Kirkwood, Thomas Christian Südhof, Jie Shen · 2010 · Journal of Neurochemistry
  9. ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila
    Atish Ganguly, R. M. Renny Feldman, Ming Guo · 2007 · Human Molecular Genetics
  10. Copy Number Variants in Alzheimer’s Disease
    Denis Cuccaro, Elvira Valeria De Marco, Rita Cittadella, Sebastiano Cavallaro · 2016 · Journal of Alzheimer s Disease
  11. Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal
    Chandra Sekhar Kuruva, P. Hemachandra Reddy · 2016 · Drug Discovery Today
  12. Identification of New Presenilin Gene Mutations in Early-Onset Familial Alzheimer Disease
    Andrea Tedde, Benedetta Nacmias, Monica Ciantelli, Paolo Forleo, Elena Cellini, Silvia Bagnoli, Carolina Piccini, Paolo Caffarra, Enrico Ghidoni, M. Paganini et al. · 2003 · Archives of Neurology
  13. Closing in on the Amyloid Cascade
    Robert W. Doms, Jason T. Huse · 2000 · Molecular Neurobiology
  14. Induction of presenilins in the rat brain after middle cerebral arterial occlusion
    Keith R. Pennypacker, Herman Hernandez, Stanley Anthony Benkovic, David Morgan, Alison E. Willing, Paul R Sanberg · 1999 · Brain Research Bulletin
  15. Review
    Marcel M. Verbeek, D.J. Ruiter, Robert M.W. de Waal · 1997 · Biological Chemistry
  16. Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease
    Jeannine M. Heckmann · 2003 · Brain
  17. Linkage and Association Studies Identify a Novel Locus for Alzheimer Disease at 7q36 in a Dutch Population-Based Sample
    Rosa Rademakers, Marc Cruts, Kristel Sleegers, Bart Dermaut, Jessie Theuns, Yurii S. Aulchenko, Stefan Weckx, Tim De Pooter, Marleen Van den Broeck, Ellen Corsmit et al. · 2005 · The American Journal of Human Genetics
  18. Characterization of human presenilin 1 transgenic rats: increased sensitivity to apoptosis in primary neuronal cultures
    Christian Czech, Mathieu J. Lesort, Günter L. Tremp, Faraj Terro, V Blanchard, Brigitte Schombert, Nathalie Carpentier, Sylvie Dreisler, Bruno Bonici, Akihiko Takashima et al. · 1998 · Neuroscience
  19. Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1
    Szapacs, Matthew E, Numis, Adam L, Andrews, Anne M · 2004 · Neurobiology of Disease
  20. Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction
    Montserrat Soler‐López, Nahuai Badiola, Andreas Zanzoni, Patrick Aloy · 2012 · BioEssays
  21. Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer's disease animal model
    Xiaorui Cheng, Xiuliang Cui, Yue Zheng, Guirong Zhang, Peng Li, Huang Huang, Yueying Zhao, Xiaochen Bo, Shengqi Wang, Wenxia Zhou et al. · 2013 · Frontiers in Aging Neuroscience
  22. Familial Alzheimer's disease sustained by presenilin 2 mutations: Systematic review of literature and genotype–phenotype correlation
    Canevelli, Marco, Piscopo, Paola, Talarico, Giuseppina, Vanacore, Nicola, Blasimme, Alessandro, Crestini, Alessio, Tosto, Giuseppe, Troili, Fernanda, Lenzi, Gian Luigi, Confaloni, Annamaria et al. · 2014 · Neuroscience & Biobehavioral Reviews
  23. Genetic studies in Alzheimer's disease
    Ya‐Ping Tang, Elliot S. Gershon · 2003 · Dialogues in Clinical Neuroscience
  24. Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's disease
    Arun Kumar Somavarapu, Kasper P. Kepp · 2016 · Journal of Neurochemistry
  25. A presenilin 1 mutation (Ser169Pro) associated with early-onset AD and myoclonic seizures
    Mario Ezquerra, Cristóbal Carnero Pardo, Rafael Blesa, Josep Lluis Gelpí, F Ballesta, Rafael Oliva · 1999 · Neurology
  26. Amyloid-β Protein Precursor (AβPP) Intracellular Domain-associated Protein-1 Proteins Bind to AβPP and Modulate Its Processing in an Isoform-specific Manner
    Enrico Ghersi, Cristiana Noviello, Luciano D'adamio · 2004 · Journal of Biological Chemistry
  27. A Novel Mutation in the PSEN2 Gene (T430M) Associated With Variable Expression in a Family With Early-Onset Alzheimer Disease
    Mario Ezquerra, Alberto Lleó, Magda Castellvı́, Rosa Queralt, Pilar Santacruz, Pau Pástor, José Luís Molinuevo, Rafael Blesa, Rafael Oliva · 2003 · Archives of Neurology
  28. Familial Alzheimer's disease genes in Japanese
    Kohei Kamimura, Hiroshi Tanahashi, Hideki Yamanaka, Keikichi Takahashi, Takashi Asada, Takeshi Tabira · 1998 · Journal of the Neurological Sciences
  29. The genetics of Alzheimer's disease
    David Chaim Rubinsztein · 1997 · Progress in Neurobiology
  30. Chasing genes in Alzheimer?s and Parkinson?s disease
    Aida Maria Bertoli‐Avella, Ben A. Oostra, Peter Heutink · 2004 · Human Genetics
  31. The Glu318Gly mutation of the presenilin‐1 gene does not necessarily cause Alzheimer's disease
    Kari M. Mattila, Charlotte Forsell, Tuula Pirttilä, Juha O. Rinne, Terho J. Lehtimäki, Matias Röyttä, Lena Lilius, Anne Eerola, Peter St George‐Hyslop, Harry Frey et al. · 1998 · Annals of Neurology
  32. Glycosylphosphatidylinositol-anchored Proteins Play an Important Role in the Biogenesis of the Alzheimer's Amyloid β-Protein
    Kumar Sambamurti, Daniel Sevlever, Thillai Koothan, Lawrence M. Refolo, Inga Pinnix, Swetal Gandhi, Luisa Onstead, Linda H. Younkin, C.-M. Prada, Debra Yager et al. · 1999 · Journal of Biological Chemistry
  33. Dual Roles of Proteasome in the Metabolism of Presenilin 1
    Toshiyuki Honda, Kaori Yasutake, Naomi Nihonmatsu, Mark Mercken, Hiroshi Takahashi, Ohoshi Murayama, Miyuki Murayama, Kazuki Sato, Akira Omori, Satoshi Tsubuki et al. · 1999 · Journal of Neurochemistry
  34. The Osaka FAD Mutation E22Δ Leads to the Formation of a Previously Unknown Type of Amyloid β Fibrils and Modulates Aβ Neurotoxicity
    Oxana Yu. Ovchinnikova, Verena H. Finder, Ivana Vodopivec, Roger M. Nitsch, Rudi Glockshuber · 2011 · Journal of Molecular Biology
  35. Rarity of the Alzheimer Disease–ProtectiveAPPA673T Variant in the United States
    Li-San Wang, Adam Christian Naj, Robert Graham, Paul K. Crane, Brian W. Kunkle, Carlos Cruchaga, Josue D. Gonzalez Murcia, Lisa Cannon‐Albright, Clinton T. Baldwin, Henrik Zetterberg et al. · 2014 · JAMA Neurology
  36. Structure, mechanism and inhibition of γ-secretase and presenilin-like proteases
    Michael S. Wolfe · 2010 · Biological Chemistry
  37. Key Role of Mitochondria in Alzheimer’s Disease Synaptic Dysfunction
    Virve Cavallucci, Caterina Ferraina, Marcello D’Amelio · 2013 · Current Pharmaceutical Design
  38. Drosophila Signal Peptide Peptidase Is an Essential Protease for Larval Development
    David J. Casso, Soichi Tanda, Brian Biehs, Bruno Martoglio, Thomas B. Kornberg · 2005 · Genetics
  39. Perspective Insights into Disease Progression, Diagnostics, and Therapeutic Approaches in Alzheimer's Disease: A Judicious Update
    Arif Tasleem Jan, Mudsser Azam, Safikur Rahman, Angham M. S. Almigeiti, Duk Hwan Choi, Eun Ju Lee, Qazi Mohd Rizwanul Haq, Inho Choi · 2017 · Frontiers in Aging Neuroscience
  40. Cytoplasmic domain of the ?-amyloid protein precursor of Alzheimer's disease: Function, regulation of proteolysis, and implications for drug development
    Megan L. Kerr, David Henry Small · 2005 · Journal of Neuroscience Research
  41. Generation of Transgenic Zebrafish Expressing Green Fluorescent Protein Under Control of Zebrafish Amyloid Precursor Protein Gene Regulatory Elements
    Ju-Ahng Lee, Gregory J. Cole · 2007 · Zebrafish
  42. Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically
    Mariagrazia Grilli, Enrica Diodato, Gianluca Lozza, R. Brusa, María Jesús Casarini, Daniela Letizia Uberti, Richard F. Rozmahel, David A. Westaway, Peter St George‐Hyslop, Maurizio Memo et al. · 2000 · Proceedings of the National Academy of Sciences
  43. Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing
    Keith D. Coon, Jon Valla, Szabolics Szelinger, Lonnie E. Schneider, Tracy L. Niedzielko, Kevin M. Brown, John V. Pearson, Rebecca F. Halperin, Travis L. Dunckley, Andreas Papassotiropoulos et al. · 2006 · Mitochondrion
  44. A genome‐wide linkage analysis of dementia in the Amish
    Daniel W. Hahs, Jacob L. McCauley, Amy E. Crunk, Lynne L. McFarland, Perry C. Gaskell, Lan Jiang, Susan H. Slifer, Jeffery M. Vance, William K. Scott, Kathleen Anne Welsh-Bohmer et al. · 2006 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
  45. A novel missense mutation in the presenilin-1 gene in a familial Alzheimer's disease pedigree with abundant amyloid angiopathy
    Minoru Yasuda, Kiyoshi Maeda, Yoshitaka Ikejiri, Toshio Kawamata, Shigetoshi Kuroda, Chikako Tanaka · 1997 · Neuroscience Letters
  46. Wide Range of Disease Onset in a Family With Alzheimer Disease and a His163Tyr Mutation in the Presenilin-1 Gene
    Karin Axelman, Hans Basun, Lars Lannfelt · 1998 · Archives of Neurology
  47. Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4.
    V S Rao, L. Adrienne Cupples, Cornelia M. van Duijn, Alexander Kurz, Robert C. Green, Helena Chang Chui, Ranjan Duara, Sanford H. Auerbach, Ladislav Volicer, J Wells et al. · 1996 · PubMed Central
  48. Insights on the Use of Transgenic Mice Models in Alzheimer’s Disease Research
    Pádua, Mafalda Soares, Guil-Guerrero, José L., Prates, José A. M., Lopes, Paula Alexandra · 2024 · International Journal of Molecular Sciences
  49. The role of histidines in amyloid β fibril assembly
    Kristoffer Brännström, Tohidul Islam, Linda Sandblad, Anders Olofsson · 2017 · FEBS Letters
  50. Alzheimer’s Disease: From Genetic Variants to the Distinct Pathological Mechanisms
    Qiying Sun, Nina Xie, Beisha Tang, Rena Li, Yong Shen · 2017 · Frontiers in Molecular Neuroscience
  51. Crucial players in Alzheimer’s disease and diabetes mellitus: Friends or foes?
    Adriana Kubis-Kubiak, Anna Rorbach-Dolata, Agnieszka Piwowar · 2019 · Mechanisms of Ageing and Development
  52. Substrate recognition and processing by γ-secretase
    Michael S. Wolfe · 2019 · Biochimica et Biophysica Acta (BBA) - Biomembranes
  53. Genetic Mouse Models of Neurodegenerative Diseases
    Alzbeta Kralova Trancikova, David Ramonet, Darren J. Moore · 2011 · Progress in molecular biology and translational science
  54. Rab GTPases, Membrane Trafficking and Diseases
    Guangpu Li · 2011 · Current Drug Targets
  55. The neurochemistry of Alzheimer's disease
    Kaj Blennow, Richard F. Cowburn · 1996 · Acta Neurologica Scandinavica
  56. Environment enrichment rescues the neurodegenerative phenotypes in presenilins‐deficient mice
    Suzhen Dong, Chunxia Li, Pu Wu, Joe Z. Tsien, Yinghe Hu · 2007 · European Journal of Neuroscience
  57. Genetic complexity of Alzheimer's disease: Successes and challenges
    Ekaterina A. Rogaeva, Toshitaka Kawarai, Peter St George‐Hyslop · 2006 · Journal of Alzheimer s Disease
  58. On the mechanism of SPP‐catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane
    Marius K. Lemberg, Bruno Martoglio · 2004 · FEBS Letters
  59. A Concise Review on Oxidative Stress-Mediated Ferroptosis and Cuproptosis in Alzheimer’s Disease
    Xudong Huang · 2023 · Cells
  60. Structural Biology of Presenilins and Signal Peptide Peptidases
    Taisuke Tomita, Takeshi Iwatsubo · 2013 · Journal of Biological Chemistry
  61. Explorative and targeted neuroproteomics in Alzheimer's disease
    Ann Brinkmalm, Erik Portelius, Annika Öhrfelt, Gunnar Brinkmalm, Ulf Andréasson, Johan Gobom, Kaj Blennow, Henrik Zetterberg · 2015 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  62. Partial Loss of Presenilin Impairs Age-Dependent Neuronal Survival in the Cerebral Cortex
    Hirotaka Watanabe, Minah Iqbal, Jin Zheng, Mary Wines-Samuelson, Jie Shen · 2014 · Journal of Neuroscience
  63. The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access
    Arun Kumar Somavarapu, Kasper P. Kepp · 2016 · Neurobiology of Disease
  64. AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging
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  65. Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease
    Ying Gao, Ru‐Jing Ren, Zilin Zhong, Eric B. Dammer, Qianhua Zhao, Shan Shan, Zheng Zhou, Xia Li, Yueqi Zhang, Hailun Cui et al. · 2019 · Neurobiology of Aging
  66. Model validity for preclinical studies in precision medicine: precisely how precise do we need to be?
    Abigail L. D. Tadenev, Robert W. Burgess · 2019 · Mammalian Genome
  67. Activated cAMP-response Element-binding Protein Regulates Neuronal Expression of Presenilin-1
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  68. In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain
    Keith J. Page, Richard D. Hollister, Rudolph E. Tanzi, Bradley T. Hyman · 1996 · Proceedings of the National Academy of Sciences
  69. Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype
    Eileen P. Ahearn, Marcy C. Speer, Y.T. Chen, David C. Steffens, Frederick Cassidy, Susan A. Van Meter, James M. Provenzale, Richard H. Weisler, Kousik Krishnan · 2002 · American Journal of Medical Genetics
  70. Presenilin‐1 protein expression in familial and sporadic Alzheimer's disease
    Allan I. Levey, Craig J. Heilman, James J. Lah, Norman R. Nash, Howard D. Rees, Masakazu Wakai, Suzanne Samuels Mirra, David B. Rye, David Nochlin, Thomas D. Bird et al. · 1997 · Annals of Neurology
  71. Recent Advances in the Genetics of Alzheimer's Disease
    Ephrat Levy‐Lahad, Debby W. Tsuang, Thomas D. Bird · 1998 · Journal of Geriatric Psychiatry and Neurology
  72. Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor
    Wiep Scheper · 2000 · Human Molecular Genetics
  73. Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression
    Jessie Theuns · 2003 · Human Molecular Genetics
  74. Regulation of Amyloid Precursor Protein Processing by Presenilin 1 (PS1) and PS2 in PS1 Knockout Cells
    James J. Palacino, Bridget E. Berechid, Prince Alexander, Christopher B. Eckman, Steven G. Younkin, Jeffrey S. Nye, Benjamin L. Wolozin · 2000 · Journal of Biological Chemistry
  75. Identification and characterization of presenilin I‐467, I‐463 and I‐374
    Naruhiko Sahara, Yuichi Yahagi, Hideyuki Takagi, Takefumi Kondo, Masayasu Okochi, Mihoko Usami, Takuji Shirasawa, Hiroshi Mori · 1996 · FEBS Letters
  76. Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons
    Masato Maesako, Mei CQ Houser, Yuliia Turchyna, Michael S. Wolfe, Oksana Berezovska · 2021 · Journal of Neuroscience
  77. Knockdown of Amyloid Precursor Protein: Biological Consequences and Clinical Opportunities
    Gabriele, Rebecca M. C., Abel, Emily, Fox, Nick C., Wray, Selina, Arber, Charles · 2022 · Frontiers in Neuroscience
  78. Carbonic Anhydrase-8 Regulates Inflammatory Pain by Inhibiting the ITPR1-Cytosolic Free Calcium Pathway
    Gerald Z. Zhuang, Benjamin E. Keeler, Jeff Grant, Laura K. Bianchi, Eugene S. Fu, Yan Ping Zhang, Diana M. Erasso, Jian-Guo Cui, Tim Wiltshire, Qiongzhen Li et al. · 2015 · PLoS ONE
  79. Successive cleavage of β-amyloid precursor protein by γ-secretase
    Satoru Funamoto, Shinji Tagami, Masayasu Okochi, Maho Morishima‐Kawashima · 2020 · Seminars in Cell and Developmental Biology
  80. Effects of Family History and Apolipoprotein E ε4 Status on Cognitive Decline in the Absence of Alzheimer Dementia
    Kathleen M. Hayden · 2009 · Archives of Neurology
  81. Sequence analysis of presenilin-1 gene mutation in Japanese Alzheimer's disease patients
    Hiroshi Tanahashi, Shinobu Kawakatsu, Mitsuo Kaneko, Hideki Yamanaka, Keikichi Takahashi, Takeshi Tabira · 1996 · Neuroscience Letters
  82. Etiology and Pathophysiology of Frontotemporal Dementia, Parkinson Disease and Alzheimer Disease: Lessons from Genetic Studies
    Christian W. Wider, Zbigniew K. Wszołek · 2008 · Neurodegenerative Diseases
  83. Genetic basis of Alzheimer's dementia: role of mtDNA mutations
    Manuela M. Grazina, J. Pratas, F. Silva, Sofia A. Oliveira, Isabel J. Santana, Catarina Resende Oliveira · 2006 · Genes Brain & Behavior
  84. Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimer's disease pathology
    Satyabrata Kar, Judes Poirier, Jorge Guevara, Doris Dea, Cheryl A. Hawkes, Yves Robitaille, Rémi Quirion · 2005 · Neurobiology of Aging
  85. 11. Molecular genetics of Alzheimer's disease
    John Hardy, M. J. Owen, Alison Goate, Louise James, A. R. Haynes, R. Williamson, Penelope K. Roques, Martin N. Rossor, M. J. Mullan · 1989 · Springer eBooks
  86. Alzheimer's Disease and Down Syndrome: From Meiosis to Dementia
    Artūras Petronis · 1999 · Experimental Neurology
  87. Regulatory region variability in the human presenilin-2 (PSEN2) gene: potential contribution to the gene activity and risk for AD
    N Riazanskaia, Walter J. Lukiw, Anastasia P. Grigorenko, Г. И. Коровайцева, Gennady A. Dvoryanchikov, Y Moliaka, Michael Nicolaou, Lindsay A. Farrer, Nicolas Guillermo Bazan, Evgeny Ivanovich Rogaev · 2002 · Molecular Psychiatry
  88. No association found between Alzheimer's disease and a mitochondrial tRNA glutamine gene variant
    Michelle A. Wragg, Chris J. Talbot, John C. Morris, Corinne L. Lendon, Alison Goate · 1995 · Neuroscience Letters
  89. Genetic Epidemiology of Alzheimer Disease
    Arjen J. C. Slooter, Cornelia M. van Duijn · 1997 · Epidemiologic Reviews
  90. Unraveling the Genetic Landscape of Neurological Disorders: Insights into Pathogenesis, Techniques for Variant Identification, and Therapeutic Approaches
    Zeba Firdaus, Xiaogang Li · 2024 · International Journal of Molecular Sciences
  91. The impact of rare genetic variants on Alzheimer disease
    Lara De Deyn, Kristel Sleegers · 2025 · Nature Reviews Neurology
  92. Neural stem cells could serve as a therapeutic material for age-related neurodegenerative diseases
    Sarawut Suksuphew · 2015 · World Journal of Stem Cells
  93. Clinicopathological concordance and discordance in three monozygotic twin pairs with familial Alzheimer's disease
    Kiri L. Brickell, James B. Leverenz, Ellen J. Steinbart, Malia C. Rumbaugh, Gerard D. Schellenberg, David Nochlin, Thomas H. Lampe, Ida E. Holm, Vivianna M. Van Deerlin, Wuxing Yuan et al. · 2007 · Journal of Neurology Neurosurgery & Psychiatry
  94. Toward the structure of presenilin/γ-secretase and presenilin homologs
    Michael S. Wolfe · 2013 · Biochimica et Biophysica Acta (BBA) - Biomembranes
  95. Apolipoprotein E region molecular signatures of Alzheimer's disease
    Alexander M. Kulminski, Jian V. Huang, Jiayi Wang, Liang He, Yury Loika, Irina V. Culminskaya · 2018 · Aging Cell
  96. Alzheimer's Disease and tauopathy studies in flies and worms
    Jill S. Wentzell, Doris Kretzschmar · 2010 · Neurobiology of Disease
  97. Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation
    Annakaisa Haapasalo, Jayashree Viswanathan, Lars Bertram, Hilkka S. Soininen, Rudolph E. Tanzi, Mikko O. Hiltunen · 2010 · Biochemical Society Transactions
  98. Testing the amyloid cascade hypothesis: Prevention trials in autosomal dominant Alzheimer disease
    Levin, Johannes, Vöglein, Jonathan, Quiroz, Yakeel T., Bateman, Randall J., Ghisays, Valentina, Lopera, Francisco, McDade, Eric, Reiman, Eric, Tariot, Pierre N., Morris, John C. · 2022 · Alzheimer's & Dementia
  99. Amyloid β Protein in Plasma as a Diagnostic Marker for Alzheimer’s Disease
    Iwatsubo, T. · 1998 · Neurobiology of Aging
  100. Microglial APOE3 Christchurch protects neurons from Tau pathology in a human iPSC-based model of Alzheimer’s disease
    Sun, Guoqiang George, Wang, Cheng, Mazzarino, Randall C., Perez-Corredor, Paula Andrea, Davtyan, Hayk, Blurton-Jones, Mathew, Lopera, Francisco, Arboleda-Velasquez, Joseph F., Shi, Yanhong · 2024 · Cell Reports