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Cited by 299

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The Chromodomain Protein Swi6: A Key Component at Fission Yeast Centromeres

Ekwall, Karl, Javerzat, Jean-Paul, Lorentz, Axel, Schmidt, Henning, Cranston, Gwen, Allshire, Robin·1995·Science

Abstract

Centromeres attach chromosomes to the spindle during mitosis, thereby ensuring the equal distribution of chromosomes into daughter cells. Transcriptionally silent heterochromatin of unknown function is associated with centromeres in many organisms. In the fission yeast Schizosaccharomyces pombe , the silent mating-type loci, centromeres, and telomeres are assembled into silent heterochromatin-like domains. The Swi6 chromodomain protein affects this silencing, and now it is shown that Swi6p localizes with these three chromosomal regions. In cells lacking Swi6p, centromeres lag on the spindle during anaphase and chromosomes are lost at high rates. Thus, Swi6p is located at fission yeast centromeres and is required for their proper function.

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Crossref · 10.1126/science.7660126

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Metadata

Authors
Ekwall, K., Javerzat, J.-P., Lorentz, A., Schmidt, H., Cranston, G., & Allshire, R.
Venue
Science
Published
1995-09-08
Volume
269
Issue
5229
Pages
1429-1431
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2029301727
Cited by
299
References
1
FWCI
4.03
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The Chromodomain Protein Swi6: A Key Component at Fission Yeast Centromeres. https://app.cochat.ai/papers/10.1126/science.7660126
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Ekwall, K., Javerzat, J.-P., Lorentz, A., Schmidt, H., Cranston, G., & Allshire, R. (1995). The Chromodomain Protein Swi6: A Key Component at Fission Yeast Centromeres. Science. https://doi.org/10.1126/science.7660126

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.